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The distinction between tuberculosis and sarcoidosis presents sometimes a clinical challenge. Their sequential occurrence in the same patient is uncommon. We present the case of a 42-year-old female with a proven diagnosis of tuberculous lymphadenitis who has developed successively nasal tuberculosis and pulmonary sarcoidosis respectively after 10 and 14 months of antituberculosis treatment. The patient presented with bilateral cervical lymphadenopathy. Tuberculin skin test was negative. Chest radiography was normal. An excision biopsy was taken and histopathological examination established tuberculosis diagnosis. Therapy with antituberculosis drugs was started, and cervical lymphadenopathy showed progressive resolution. Subsequently, nearly 10 months after, the patient developed new cervical lymphadenopathies and nasal obstruction. Tuberculosis of the nasal mucosa was confirmed by biopsy. Antituberclosis bitherapy was enhanced by ofloxacin and ethambutol. Thoracic CT scan showed several nodular elements in both lungs, with bilateral enlarged mediastinal adenopathy. Bronchoalveolar lavage showed a lymphocytic alveolitis with a CD4/CD8 ratio of 5, consistent with the diagnosis of pulmonary sarcoidosis. Corticosteroid treatment, in form of oral prednisolone was introduced, 3 months after sarcoidosis diagnosis have been setteled; because of pulmonary fibrosis noticed on thoracic CT. Systemic corticotherapy was continued for a further period of 3 years, until all the lesions cleared out. The present case emphasizes the possible association between tuberculosis and sarcoidosis.
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Non-recurrent Laryngeal nerve is constantly associated with Arteria Lusoria. Knowing this association is the basis of predicting this condition preoperatively. Ultrasonography assessment before thyroid and parathyroid surgery should include identification of brachiocephalic trunk division. Absence of its visualization indicates Arteria Lusoria and then non-recurrent laryngeal nerve.
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Ectopic thyroid tissue (ETT) lateral to the midline is rare. Its occurrence in the carotid bifurcation is exceptional. We present a 45 years woman who consulted with a slow growing right cervical swelling. Clinical examination Ultrasonography, contrast enhanced CT and cervical MRI concluded to a paraganglioma. Intra-operatively, the tumor didn't have the characteristic aspect of a paraganglioma. Complete excision was performed. Histology concluded to an ectopic micro-vesicular thyroid adenoma.Previous literature was reviewed to summarize clinical and radiologic characteristics of such rare entity. Despite its rarity, ETT must be included in the differential diagnosis of cervical paraganglioma.
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Paraganglioma/diagnóstico por imagen , Disgenesias Tiroideas/diagnóstico , Neoplasias de la Tiroides/diagnóstico , Diagnóstico Diferencial , Femenino , Humanos , Imagen por Resonancia Magnética , Persona de Mediana Edad , Disgenesias Tiroideas/patología , Disgenesias Tiroideas/cirugía , Neoplasias de la Tiroides/patología , Neoplasias de la Tiroides/cirugía , Tomografía Computarizada por Rayos X , UltrasonografíaRESUMEN
A 41-year-old patient was hospitalised for a chronic right parotid mass. A cervical ultrasound revealed a cystic mass of the parotid. Cervical MRI found a ductal ectasia of the parotid and submandibular glands associated with a retention cyst of the right parotid. He had a right total parotidectomy. Histopathological examination of the lesion revealed a multilocular cystic mass with a diffuse glandular ectasia of salivary ducts. The patient had an uneventful postoperative course without any recurrence of symptoms.
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Dilatación Patológica/diagnóstico por imagen , Enfermedades de las Parótidas/diagnóstico por imagen , Glándula Parótida/patología , Procedimientos de Cirugía Plástica , Conductos Salivales/diagnóstico por imagen , Ultrasonografía , Adulto , Biopsia con Aguja Fina , Dilatación Patológica/patología , Dilatación Patológica/cirugía , Humanos , Masculino , Enfermedades de las Parótidas/patología , Enfermedades de las Parótidas/cirugía , Conductos Salivales/patología , Conductos Salivales/cirugía , Resultado del TratamientoRESUMEN
OBJECTIVES: The aims of this study were to determine predictive factors of paradoxical reaction in patients with cervical lymph node tuberculosis (TB) and to discuss the therapeutic management of this condition. MATERIALS AND METHODS: A retrospective study was performed of 501 patients managed for cervical lymph node TB over a period of 12 years (from January 2000 to December 2011). Statistical data were analyzed using IBM SPSS Statistics version 20.0. RESULTS: Paradoxical reaction occurred in 67 patients (13.4%), with a median delay to onset after starting TB treatment of 7 months. Lymph node size ≥3cm and associated extra-lymph node TB were independently associated with paradoxical reaction. Treatment consisted of surgical excision (71.6%), restarting quadruple therapy (10.4%), reintroduction of ethambutol (23.8%), and addition of ciprofloxacin (20.8%); steroids were given in two cases . All patients recovered after an average treatment duration of 14.91±7.03 months. CONCLUSION: The occurrence of paradoxical reaction in cervical lymph node TB seems to be predicted by associated extra-lymph node TB and a swelling size ≥3cm. The treatment of paradoxical reaction remains unclear and more randomized trials are necessary to improve its management.
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Antituberculosos/uso terapéutico , Tuberculosis Ganglionar/tratamiento farmacológico , Adulto , Antibacterianos/uso terapéutico , Ciprofloxacina/uso terapéutico , Manejo de la Enfermedad , Etambutol/uso terapéutico , Femenino , Humanos , Ganglios Linfáticos/efectos de los fármacos , Ganglios Linfáticos/patología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento , Tuberculosis Ganglionar/patología , Tuberculosis Ganglionar/cirugía , Adulto JovenAsunto(s)
Linfoma de Células B de la Zona Marginal/diagnóstico , Mucosa Bucal/diagnóstico por imagen , Neoplasias de la Boca/diagnóstico , Adulto , Biomarcadores de Tumor , Humanos , Linfoma de Células B de la Zona Marginal/química , Linfoma de Células B de la Zona Marginal/diagnóstico por imagen , Linfoma de Células B de la Zona Marginal/patología , Imagen por Resonancia Magnética , Masculino , Mucosa Bucal/química , Mucosa Bucal/patología , Neoplasias de la Boca/química , Neoplasias de la Boca/diagnóstico por imagen , Neoplasias de la Boca/patologíaAsunto(s)
Teratoma/diagnóstico , Neoplasias de la Tiroides/diagnóstico , Adolescente , Femenino , HumanosRESUMEN
OBJECTS: To discuss clinical presentation and therapeutic approaches of facial paralysis in acute otitis media. METHODS: We present five cases of facial palsy in children with acute otitis media managed in our ENT department during a period of 12 years (2001-2012). RESULTS: The mean age was 14.2 years; sex ratio was 0.66. All patients presented with a facial asymmetry, but only 3 of them had otalgia before the onset of facial asymmetry. The facial palsy delay was 3.3 days. The ear examination showed that the tympanic membrane was congestive in 4 patients, associated with a bulging in 2 patients, and a small perforation in one patient. Our patients presented grade III to IV initial facial palsy according to House and Brackmann staging. Computed tomography scan revealed a dehiscence of the bony facial canal in one patient. Antibiotic therapy associated with intravenous corticosteroids was administered in all patients. All patients underwent a facial kinesis therapy. A progressive improvement of facial palsy was observed in 4 patients and complete recovery of facial function in one case. DISCUSSION: Conservative treatment associating intravenous antibiotic and corticosteroids with or without myringotomy is the standard approach.
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Parálisis Facial/etiología , Otitis Media/complicaciones , Enfermedad Aguda , Adolescente , Corticoesteroides/administración & dosificación , Adulto , Antibacterianos/administración & dosificación , Niño , Preescolar , Quimioterapia Combinada , Nervio Facial/patología , Parálisis Facial/diagnóstico , Parálisis Facial/tratamiento farmacológico , Femenino , Estudios de Seguimiento , Humanos , Lactante , Infusiones Intravenosas , Masculino , Persona de Mediana Edad , Otitis Media/diagnóstico , Otitis Media/tratamiento farmacológico , Otoscopía , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Adulto JovenRESUMEN
OBJECTIVES: Mutations in GJB2 are found to be responsible for 50% of congenital autosomal recessive non-syndromic hearing loss, one of the most important mutations in this gene is the c.35delG, which is responsible for the majority of GJB2 related deafness in the Tunisian population. The aim of this study was to determine the molecular etiology of hearing loss in two Tunisian individuals. METHODS: We screened two Tunisian individuals affected by congenital, bilateral, profound, sensorineural hearing loss for mutations in GJB2 gene using PCR and direct sequencing. RESULTS: We identified a novel frameshift mutation in the GJB2 gene, the c.405delC resulting in a truncated protein (p.Tyr136Thrfs*32). It was found in compound heterozygosity with the c.35delG in two non-consanguineous unrelated families from Tunisia. One patient underwent a cochlear implant at 4 years. Initial evaluations post-implantation indicate a successful cochlear implant outcome since the patient began to acquire language abilities and auditory sensation. CONCLUSIONS: With this novel GJB2 mutation, the mutational spectrum of this gene continues to broaden in our population. The occurrence of biallelic GJB2 mutations for the other deaf girl, despite the neonatal pain and hypotension due to complicated delivery, led us to confirm the importance of GJB2 screening for cochlear implant candidates regardless of the etiology of deafness in populations with a relatively high frequency of GJB2 mutation carriers.
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Implantación Coclear/métodos , Conexinas/genética , Sordera/genética , Mutación del Sistema de Lectura/genética , Pérdida Auditiva Sensorineural/genética , Adulto , Preescolar , Implantes Cocleares , Conexina 26 , Análisis Mutacional de ADN , Sordera/diagnóstico , Sordera/epidemiología , Sordera/cirugía , Potenciales Evocados Auditivos del Tronco Encefálico , Femenino , Estudios de Seguimiento , Genes Recesivos , Pruebas Genéticas/métodos , Genotipo , Pérdida Auditiva Sensorineural/diagnóstico , Pérdida Auditiva Sensorineural/epidemiología , Pérdida Auditiva Sensorineural/cirugía , Heterocigoto , Humanos , Incidencia , Lactante , Recién Nacido , Masculino , Linaje , Reacción en Cadena de la Polimerasa/métodos , Medición de Riesgo , Muestreo , Resultado del Tratamiento , TúnezRESUMEN
Spontaneous cholesteatoma of the external auditory canal (EAC) is an uncommon condition that is difficult to diagnose. In a patient with such a possibility, serious clinical investigation along with radiologic and histologic exploration should be performed early on because a delay in treatment can lead to severe complications. Given the rarity of EAC cholesteatoma, no therapeutic consensus has emerged. The type of management depends on the extensiveness of invasion and bone erosion and the status of the neighboring structures. The primary therapeutic objectives are to eradicate the cholesteatoma and then to fill in the residual cavity, which in our opinion can be best accomplished with a muscle flap and EAC reconstruction. Postoperative follow-up should be carried out to look for infections, stenosis, and recurrence. We report a new case of spontaneous EAC cholesteatoma, and we review its diagnostic and therapeutic challenges.