RESUMEN
The aim of this study was to characterize the clinicopathological features and prognostic factors of T1/2 size (<4 cm) gingival squamous cell carcinoma (SCC) and to verify the impact of bone invasion. This was a single-centre, retrospective cohort study involving 206 patients with gingival SCC (maxilla or mandible), treated between 2000 and 2020. The patients were divided into three subgroups based on tumour size and bone invasion. The 5-year overall survival (OS) and disease-free survival (DFS) were 80.6% and 67.6%, respectively. Histological differentiation, advanced T stage, positive resection margin, bone invasion, and postoperative adjuvant therapy were associated with a poor prognosis (P < 0.05). Multivariate Cox analysis indicated that only histological differentiation (hazard ratio (HR) 2.68, P = 0.007) and bone invasion (HR 2.08, P = 0.036) were significantly associated with DFS. Bone invasion was observed in 145 (70.4%) patients, of whom 43 (20.9%) had a T1/2 size tumour. The subgroup with bone invasion and T1/2 size showed significantly worse OS and DFS when compared to the subgroup without bone invasion and similar or worse survival when compared to the subgroup with bone invasion and T3/T4 size. Histological differentiation and bone invasion were poor prognostic factors for gingival SCC, even in cases with small-sized tumours. For suspected bone invasion in small-sized tumours, an adequate bone margin is necessary and postoperative adjunctive therapy needs to be considered.
RESUMEN
Unlike the levels of anatomical exploration, there is no consensus on the extent of lymph node dissection, or lymph node count (LNC), during selective neck dissection (SND). The aim of this study was to validate the prognostic impact of LNC on survival and to determine an optimal LNC cut-off value for SND. A retrospective investigation identified 78 patients with a diagnosis of oral squamous cell carcinoma (OSCC) who underwent SND (levels I-III or levels I-IV). LNC and clinicopathological variables were analyzed for any association with survival in Cox proportional hazards models. Based on the receiver operating characteristic curve, a cut-off value of 19 lymph nodes was found to predict overall survival (OS) (area under the curve 0.732, sensitivity 67.8%, specificity 75.0%; P=0.026) and disease-specific survival (DSS) (area under the curve 0.762, sensitivity 68.1%, specificity 77.8%; P=0.011). On Cox regression, LNC (≥19 vs. <19) was the only independent predictor of OS (hazard ratio 5.29, 95% confidence interval 1.39-20.05; P=0.014) and DSS (hazard ratio 6.76, 95% confidence interval 1.40-32.77; P=0.018). Similar results were obtained in the pathologically lymph node-negative subgroup (n=66). Based on the study findings, SND should include 19 or more lymph nodes for a survival benefit.
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Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/cirugía , Metástasis Linfática/patología , Neoplasias de la Boca/patología , Neoplasias de la Boca/cirugía , Disección del Cuello , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Estudios Longitudinales , Escisión del Ganglio Linfático , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Retrospectivos , Tasa de SupervivenciaRESUMEN
OBJECTIVE: To evaluate the ability of xenogenic bone and absorbable collagen sponge to function as an rhBMP-2 carrier and the osteoinductivity of bisphosphonate by comparison with recombinant human bone morphogenetic protein-2 (rhBMP-2). MATERIALS AND METHODS: Thirty-two Sprague-Dawley male rats were divided into four groups. Segmental ostectomy of both fibulae was performed, and the defect area was then treated with Rapiderm Pad (absorbable collagen sponge; COL_BMP) or CollaOss (xenogenic bone; XENO_BMP) with application of rhBMP-2. Alternatively, both fibulae were grafted with xenogenic bone with different bisphosphonate concentrations (XENO_Low BP, XENO_High BP). After 4 or 8 weeks, animals were sacrificed, and radiographic, histological, histomorphometric, and immunohistochemical analyses were performed. RESULTS: Recombinant human bone morphogenetic protein-2 promoted bone formation, regardless of the carrier, and exhibited continuity between the graft material and defect area. Moreover, the results showed that higher concentrations of bisphosphonate were associated with greater bone formation than lower concentrations of bisphosphonate. CONCLUSION: Absorbable collagen sponges with rhBMP-2 were advantageous in that there was no remaining graft material and that the bone was remodeled to resemble the existing fibula. The local application of bisphosphonate promoted new bone formation, particularly when used at high concentrations. High-concentration bisphosphonate induced new bone formation comparable to rhBMP-2 with lesser remaining bone material.
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Proteína Morfogenética Ósea 2/farmacología , Regeneración Ósea/efectos de los fármacos , Difosfonatos/farmacología , Animales , Trasplante Óseo , Colágeno , Portadores de Fármacos , Peroné/diagnóstico por imagen , Peroné/patología , Xenoinjertos , Masculino , Ratas , Proteínas Recombinantes/farmacologíaRESUMEN
Although osteoradionecrosis (ORN) is a serious complication of craniofacial radiotherapy, the current management methods remain suboptimal. Teriparatide (TPTD), a recombinant human parathyroid hormone (1-34), has shown beneficial effects on osseous regeneration in medication-related osteonecrosis of the jaw or periodontitis. However, TPTD therapy in irradiated bones has not been indicated yet because of the theoretical risk of osteosarcoma seen in rat models. Hence, we first report here two patients with tongue cancer with late-emerging ORN who were successfully treated with TPTD for 4-6 months with serum calcium and vitamin D supplementation. In contrast to the usual progress of ORN, the bone defect regenerated well and bone turnover markers including serum C-terminal telopeptide of type 1 collagen and osteocalcin were restored with TPTD therapy. Our experience might suggest that TPTD therapy with careful monitoring can provide an effective treatment option for patients with ORN in select refractory cases, with the benefits outweighing the potential risks.
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Conservadores de la Densidad Ósea/uso terapéutico , Maxilares , Osteorradionecrosis/tratamiento farmacológico , Teriparatido/uso terapéutico , Anciano de 80 o más Años , Femenino , Humanos , Maxilares/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Osteorradionecrosis/diagnóstico por imagen , Osteorradionecrosis/etiología , Radiografía , Radioterapia/efectos adversos , Neoplasias de la Lengua/radioterapiaRESUMEN
PURPOSE: We aimed to identify a combined prognostic factor for predicting better performance in risk stratification. MATERIALS AND METHODS: We reviewed the clinical and pathological variables of 316 patients with oral squamous cell carcinoma (OSCC) who underwent surgery. To identify a combined predictor, principal component analysis (PCA) was performed. RESULTS: Univariate analysis showed that the independent prognostic variables for overall survival (OS) were pathologic T stage (T1 vs T4, HR = 1.99, 95% CI: = 1.083-3.675, P = 0.026) and pathologic N stage (N0 vs N2, HR=1.90, 95% CI: = 1.17-3.08, P = 0.008). In the multivariate analysis, only pathologic T stage was significant (P = 0.006 and P = 0.007); however, the multivariate model was not significant (P = 0.191). The multivariate model became significant by including lymph node ratio (LNR) instead of pathologic N stage (P = 0.0025 in numeric LNR, P = 0.0007 in categorized LNR). Also, the performance of prediction model was improved by a combined prognostic factor (P = 0.0002). CONCLUSIONS: The newly identified combined prognostic factor included resection margin, differentiation, and LNR, and they were insignificant factors independently except for LNR. This combined prognostic factor showed a good performance although it did not include molecular markers; therefore, it may be used conveniently for risk stratification of patients with OSCC by combining only clinical information.
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Carcinoma de Células Escamosas/diagnóstico , Neoplasias de la Boca/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma de Células Escamosas/mortalidad , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/cirugía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/mortalidad , Neoplasias de la Boca/patología , Neoplasias de la Boca/cirugía , Estadificación de Neoplasias , Análisis de Componente Principal , Pronóstico , Estudios Retrospectivos , Medición de Riesgo/métodos , Análisis de Supervivencia , Adulto JovenRESUMEN
UNLABELLED: The administration of teriparatide (TPTD) in conjunction with periodontal care could provide faster and more favorable clinical outcomes in previously refractory bisphosphonate-related osteonecrosis of the jaws (BRONJ) cases compared to conventional dental care, combination of surgery and antimicrobial treatment. We also found that underlying vitamin D levels might influence the response to TPTD treatment. INTRODUCTION: Treatment of BRONJ is quite challenging and there are no standard treatment modalities. In this retrospective, longitudinal study, we examined whether additional TPTD administration could be beneficial for the resolution of BRONJ lesions compared to conservative management, such as antimicrobial treatment with or without surgery, and also studied the factors influencing the response to TPTD. METHODS: Twenty-four cases of intractable BRONJ were included: 15 subjects were assigned to the TPTD group and the other 9 subjects, who refused TPTD administration, were assigned to the non-TPTD group. All subjects in both groups continued calcium and vitamin D supplementation and the TPTD group additionally received a daily subcutaneous injection of 20 µg TPTD for 6 months. RESULTS: While 60.0% of the non-TPTD group showed one stage of improvement in BRONJ, 40.0% of the group did not show any improvement in disease status. In the TPTD group, 62.5% of the treated subjects showed one stage of improvement and the other 37.5% demonstrated a marked improvement, including two stages of improvement or complete healing, and there was not a single case that did not improve. The clinical improvement of BRONJ was statistically better in the TPTD group after the 6-month treatment (p < 0.05). Moreover, patients with higher baseline serum 25(OH)D levels showed better clinical therapeutic outcomes with TPTD. CONCLUSIONS: We observed the beneficial effects of TPTD on BRONJ, and subjects with optimal serum vitamin D concentrations seemed to reap the maximum therapeutic effects of TPTD. A prospective, randomized, controlled trial should be needed to further evaluate the therapeutic efficacy of TPTD in the resolution of BRONJ.
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Osteonecrosis de los Maxilares Asociada a Difosfonatos/tratamiento farmacológico , Conservadores de la Densidad Ósea/uso terapéutico , Teriparatido/uso terapéutico , Anciano , Anciano de 80 o más Años , Biomarcadores/sangre , Osteonecrosis de los Maxilares Asociada a Difosfonatos/sangre , Osteonecrosis de los Maxilares Asociada a Difosfonatos/diagnóstico por imagen , Osteonecrosis de los Maxilares Asociada a Difosfonatos/fisiopatología , Densidad Ósea/efectos de los fármacos , Remodelación Ósea/efectos de los fármacos , Terapia Combinada , Evaluación de Medicamentos/métodos , Femenino , Cuello Femoral/fisiopatología , Articulación de la Cadera/fisiopatología , Humanos , Estudios Longitudinales , Vértebras Lumbares/fisiopatología , Masculino , Persona de Mediana Edad , Radiografía , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Vitamina D/sangreRESUMEN
OBJECTIVES: The aim of this study was to identify the socioeconomic factors associated with the prevalence of periodontitis in Koreans. METHODS: Cross-sectional data from 12 763 subjects, 15 years old and above, who underwent periodontal examinations were obtained from the Korean National Health and Nutrition Examination Survey IV (2007-209). Multivariate linear and logistic regression analyses were applied to estimate the association between socioeconomic indicators and prevalence of periodontitis. RESULTS: A significant association was found between increasing age and periodontitis. Participants with higher income were less likely to have periodontitis (aOR = 0.9 and 95% CI = 0.78-0.98, and aOR = 0.7 and 95% CI = 0.60-0.80 in the middle and highest quintiles of monthly household income, respectively). In addition, participants living in rural areas were less likely to have periodontitis (aOR = 0.9 and 95% CI = 0.81-0.99), and current smokers were more likely to have periodontitis (aOR = 1.7 and 95% CI = 1.49-1.89). The analysis of comorbidities revealed that individuals with diabetes mellitus (DM) were significantly more likely to have periodontitis (aOR = 1.4 and 95% CI = 1.18-1.68). CONCLUSIONS: In a rapidly increasing Korean population, the lower socioeconomic groups as well as individuals with DM were significantly more likely to present with periodontitis.
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Diabetes Mellitus/epidemiología , Disparidades en el Estado de Salud , Renta/estadística & datos numéricos , Periodontitis/epidemiología , Adolescente , Adulto , Factores de Edad , Anciano , Comorbilidad , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Encuestas Nutricionales , Prevalencia , República de Corea/epidemiología , Población Rural/estadística & datos numéricos , Fumar/epidemiología , Adulto JovenRESUMEN
A case of adult acute lymphoblastic leukaemia is reported. A 35-year-old male presented with an osteolytic lesion of the mandible. There was no definitive involvement in other craniofacial bones. A panoramic radiograph taken 4 months previously showed no bony involvement. A complete blood count showed a slightly decreased red blood cell count, but normal white blood cell count, white blood cell differential count and platelet count. Routine chemistry revealed hypercalcemia with an increased level of parathyroid hormone-related protein. Histopathological examination of bone marrow biopsy confirmed the diagnosis of acute lymphoblastic leukaemia.
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Enfermedades Mandibulares/diagnóstico , Osteólisis/diagnóstico , Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico , Adulto , Pérdida de Hueso Alveolar/diagnóstico , Diagnóstico Diferencial , Resultado Fatal , Humanos , Hipercalcemia/diagnóstico , Masculino , Imagen Multimodal , Proteína Relacionada con la Hormona Paratiroidea/sangre , Tomografía de Emisión de Positrones , Radiografía Panorámica , Tomografía Computarizada por Rayos XRESUMEN
UNLABELLED: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious side effect of bisphosphonate therapy. The incidence of BRONJ is known to be low among patients treated with oral bisphosphonates. We investigated the prevalence, demographics, clinical manifestations, and treatment outcome of 24 patients with oral BRONJ in Asian populations. INTRODUCTION: The long-term safety of oral bisphosphonates is clinically important considering the rare but potentially serious complications such as bisphosphonate-related osteonecrosis of the jaw (BRONJ) versus the effect of reducing and preventing osteoporotic fracture. The incidence of BRONJ is known to be low among patients treated with oral bisphosphonates around the world. However, the prevalence in those taking oral bisphosphonates for osteoporosis in Asian populations is unknown. Moreover, a recent article, showing that the majority of reported patients who received alendronate were Asian American, raised concern about the prevalence of oral BRONJ in Asian populations. The objective of this study was to investigate the estimated prevalence, clinical characteristics, and treatment outcome of oral BRONJ in Asian populations. METHODS: From October 2005 to December 2008, a retrospective review of medical charts identified 24 patients receiving oral bisphosphonates diagnosed as BRONJ at the Department of Oral and Maxillofacial Surgery, Yonsei University Dental Hospital, Seoul, South Korea. RESULTS: The estimated prevalence of oral BRONJ was 0.05-0.07%. The average oral bisphosphonate treatment duration was 43.1 months (range, 5-120 months). Treatment with oral antibiotics and/or surgery including sequestrectomy or alveolectomy showed relatively favorable results. CONCLUSIONS: The prevalence of oral BRONJ in Korea is similar to that reported previously in Western populations. We suggest that recognition of BRONJ and appropriate management pre- and post-dental surgery might reduce the frequency of BRONJ among patients receiving oral bisphosphonates.
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Conservadores de la Densidad Ósea/efectos adversos , Difosfonatos/efectos adversos , Enfermedades Maxilomandibulares/inducido químicamente , Osteonecrosis/inducido químicamente , Administración Oral , Anciano , Anciano de 80 o más Años , Conservadores de la Densidad Ósea/uso terapéutico , Difosfonatos/uso terapéutico , Esquema de Medicación , Femenino , Humanos , Enfermedades Maxilomandibulares/diagnóstico por imagen , Enfermedades Maxilomandibulares/terapia , Masculino , Persona de Mediana Edad , Osteonecrosis/diagnóstico por imagen , Osteonecrosis/terapia , Osteoporosis/tratamiento farmacológico , Radiografía Panorámica , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
Transcatheter arterial chemoembolization is one of the most common treatment modalities for hepatocellular carcinoma. Transcatheter arterial chemoembolization is considered to be a relatively safe procedure, but transcatheter arterial chemoembolization is associated with a number of disastrous complications. Among the ischaemic complications caused by transcatheter arterial chemoembolization, spinal cord injury is very rare, but can occur via the intercostal or lumbar arteries. We report two cases of extremely rare spinal cord injuries after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. The patients had sensory loss below the T9 or T10 dermatomes and paraparesis or paraplegia within 6-8h after transcatheter arterial chemoembolization. One patient sustained paraplegia until death 2 months after transcatheter arterial chemoembolization and the other patient recovered almost completely 2 months after transcatheter arterial chemoembolization.
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Carcinoma Hepatocelular/terapia , Cateterismo Periférico/efectos adversos , Quimioembolización Terapéutica/efectos adversos , Neoplasias Hepáticas/terapia , Traumatismos de la Médula Espinal/etiología , Anciano , Quimioembolización Terapéutica/métodos , Humanos , Masculino , Persona de Mediana Edad , Paraplejía/etiologíaRESUMEN
PURPOSE: To demonstrate the long-term treatment outcomes of endovenous laser ablation (EVA) of incompetent small saphenous veins (SSV) with a 980-nm diode laser. MATERIALS AND METHODS: Eighty-four patients (96 limbs), with varicose veins and reflux in the SSV on duplex ultrasound examination, were treated with a 980-nm diode laser under ultrasound- or fluoroscopy-guidance. Patients were evaluated at 1 week and 1, 3, 6 months, 1 year and yearly thereafter. RESULTS: In the 96 limbs, the technical success rate was 100%. The SSV remained closed in 89 of 93 limbs (96%) after 1 month, all of 82 limbs after 6 months, 77 limbs after 1 year, 71 limbs after 2 years and 55 limbs after 3 years. In four limbs where recanalisation was observed, repeat EVA was done resulting in successful obliteration of the SSV. No major complication occurred however bruising (27%), tightness or pain (13%) and paraesthesia (4.2%) were observed. CONCLUSION: Endovenous laser ablation with a 980-nm laser wavelength is an easy and safe procedure in incompetent SSVs. After successful treatment, there is a very low rate of recanalisation of the SSV, which suggests that the procedure will provide lasting results.
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Angioplastia por Láser , Láseres de Semiconductores , Vena Safena/cirugía , Várices/cirugía , Adulto , Anciano , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Factores de Tiempo , Adulto JovenRESUMEN
A case is reported of spontaneous bone formation on the maxillary sinus floor associated with the extraction socket of a maxillary impacted tooth. An impacted maxillary second premolar of a 20-year-old male had been pushed into the maxillary sinus during surgical extraction. The tooth was removed using the sinus elevation technique. After 5 months of healing, the space between the sinus floor and the socket was filled with new bone. Later, implant surgery was successfully carried out without any sinus augmentation. Osteogenic activity of sinus mucosa and the blood clot in the extraction socket beneath the elevated sinus would have been important factors in this spontaneous bone formation.
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Diente Premolar/cirugía , Seno Maxilar/fisiología , Osteogénesis/fisiología , Extracción Dental , Alveolo Dental/fisiología , Diente Impactado/cirugía , Adulto , Implantación Dental Endoósea , Implantes Dentales , Estudios de Seguimiento , Cuerpos Extraños/cirugía , Humanos , Masculino , Seno Maxilar/cirugía , Membrana Mucosa/cirugía , Oseointegración/fisiología , Alveolo Dental/cirugía , Cicatrización de Heridas/fisiologíaRESUMEN
Inflammatory myofibroblastic tumors are lesions that most often affect young adults and children. These tumors have been found in numerous extrapulmonary sites but rarely in the stomach. It is unknown whether this process is reactive or neoplastic. They are infiltrative lesions and often extend through the gastric wall, sometimes reaching adjacent organs including the esophagus, duodenum, peritoneal cavity, spleen. pancreas, and liver. These features mimic malignancy on endoscopy and radiology. We report the ultrasound, color Doppler ultrasound, and helical computed tomographic findings of a gastric inflammatory myofibroblastic tumor with peritoneal dissemination in a young adult. To our knowledge, this is the first report of color Doppler ultrasound and helical computed tomographic findings of this rare disease entity.
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Neoplasias de Tejido Muscular/diagnóstico por imagen , Neoplasias Gástricas/diagnóstico por imagen , Tomografía Computarizada Espiral , Ultrasonografía Doppler en Color , Adulto , Humanos , Inflamación/patología , Masculino , Invasividad Neoplásica , Neoplasias de Tejido Muscular/patología , Neoplasias Peritoneales/patología , Neoplasias Gástricas/patologíaRESUMEN
To clarify the clinical utility of the parietal bone graft in maxillofacial reconstruction, we performed an anatomical study by measuring the regional thickness of the parietal bone in 47 Korean adult dry skulls. Before sectioning of the calvaria, the appropriate anatomical landmarks were marked on each specimen. We measured the total thickness of the parietal bone, and the thickness of the outer and inner cortical plates at various points in each section of parietal bones using a digital caliper under the stereomicroscope. The total thickness of the parietal bone ranged from 5.04mm to 7.17mm, and there was no statistical difference in the total thickness of the parietal bone on the same points bilaterally. The parietal bone tended to be thicker toward the lambda point than at the coronal suture area. On the other hand, the outer plate of parietal bone was thickest at the point nearest to the coronal suture, and the inner plate proved thickest at the posteromedial area. In conclusion, this study showed that the better donor site of the parietal bone for maxillofacial reconstruction is located at its more posterior and medial area.
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Hueso Parietal/anatomía & histología , Adulto , Análisis de Varianza , Densidad Ósea , Trasplante Óseo , Humanos , Hueso Parietal/trasplante , Valores de Referencia , Recolección de Tejidos y ÓrganosRESUMEN
A solitary plasmacytoma occurring in the mandible of a 15-year-old Korean male 6 years after renal transplantation is reported. The tumour presented as a hyperplastic gingival overgrowth in the right madibular molar area. Histology and immunohistochemistry revealed plasmacytoma and monoclonality of the kappa chain and IgG. In situ hybridization for Epstein-Barr virus encoded RNA (EBER) showed positive signals in the tumour cells. The tumour regressed after reducing the immunosuppressive agents with concurrent radiotherapy. The patient remains in a stable condition with normal renal functions after 7 years without recurrence. This case confirms that Epstein-Barr virus associated B-lymphoproliferative disorders are still a major complication of immunosuppression.
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Trasplante de Riñón/efectos adversos , Neoplasias Mandibulares/etiología , Neoplasias Mandibulares/virología , Plasmacitoma/etiología , Plasmacitoma/virología , Adolescente , Infecciones por Virus de Epstein-Barr/etiología , Herpesvirus Humano 4/genética , Herpesvirus Humano 4/aislamiento & purificación , Humanos , Inmunosupresores/efectos adversos , Hibridación in Situ , Masculino , Neoplasias Mandibulares/patología , Neoplasias Mandibulares/radioterapia , Plasmacitoma/patología , Plasmacitoma/radioterapiaRESUMEN
Vascularized fibula flaps have many advantages in the restoration of the contour and function of the mandible. Potential disadvantages include, unreliable skin paddle and the limited volume of the fibula. This study was designed, to clarify the anatomy of the peroneal artery to the fibula and lateral leg skin, and to measure the dimensions of the fibula available for dental implant placement in Korean. Through the dissection of 63 legs of Korean cadavers, we demonstrated that in most cases the musculoperiosteal (mp) and septocutaneous (sc) branches of the peroneal artery were distributed at the middle and lower thirds of the fibula. There were double the number of mp perforators to the skin compared to sc branches. This indicates the inclusion of a generous > 1 cm cuff of Peroneous longus and flexor hallucis longus (FHL) in the distal and middle third of the fibula. The location of the nutrient foramen was just proximal to the midpoint. Thus, a 15-20 cm length of the fibula is available in Koreans and an 8 12 mm length of implant can be placed to the fibula, which provides sufficient bone to reconstruct a large mandibular defect.
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Arterias/anatomía & histología , Peroné/anatomía & histología , Pierna/irrigación sanguínea , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Pueblo Asiatico , Femenino , Peroné/irrigación sanguínea , Humanos , Corea (Geográfico) , Masculino , Persona de Mediana Edad , Colgajos QuirúrgicosRESUMEN
The spread pattern of a tumour and its extent in the mandible are important in the management of gingival cancer. Sixteen patients with gingival squamous cell carcinoma (SCC) involving the mandible in the molar region were included in this study. Resection specimens of the mandibular bone and adjacent cancer were histologically analysed to identify the type and characteristics of invasion and were compared with the radiological features. Our results showed that the actual width of invasion was underestimated to a greater extent than the actual depth of invasion. For horizontal aspects, four dentate cases had horizontal intramedullary spread underneath intact mucosa or cortical bone extended from the main foci of tumour that infiltrated through the occlusal surface. For vertical aspects, nerve invasion took place in only one of 16 specimens, while five cases showed downward infiltration beyond the inferior alveolar canal without nerve involvement, so that the pattern of tumour spread was mostly transmedullary rather than perineural in previously non-irradiated cases. These cases with deep infiltration showed the infiltrative type of invasion in the dentate mandible. And when the tumour was related with previous dental extractions or curettage, it tended to be more extensive than what was predicted from an imaging point of view. These pathological and clinical features affecting the tumour spread should be considered in the management of gingival SCC in the molar region.
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Carcinoma de Células Escamosas/patología , Neoplasias Gingivales/patología , Neoplasias Mandibulares/patología , Adulto , Anciano , Anciano de 80 o más Años , Proceso Alveolar/diagnóstico por imagen , Proceso Alveolar/patología , Densidad Ósea , Médula Ósea/diagnóstico por imagen , Médula Ósea/patología , Carcinoma de Células Escamosas/diagnóstico por imagen , Carcinoma de Células Escamosas/cirugía , Legrado , Femenino , Neoplasias Gingivales/diagnóstico por imagen , Neoplasias Gingivales/cirugía , Humanos , Masculino , Mandíbula/diagnóstico por imagen , Mandíbula/patología , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Mandibulares/cirugía , Nervio Mandibular/patología , Persona de Mediana Edad , Diente Molar , Mucosa Bucal/patología , Invasividad Neoplásica , Osteotomía , Radiografía Panorámica , Estadísticas no Paramétricas , Tomografía Computarizada por Rayos X , Extracción DentalRESUMEN
BACKGROUND: To evaluate the utility of dual-phase spiral computed tomography during gastric arteriography (CTGA) in the preoperative staging of gastric cancers. METHODS: We performed CTGA in 21 patients with pathologically proven gastric cancers. CTGA findings were prospectively analyzed and correlated with surgical and pathologic findings. Dual-phase scans were performed at 10 s (early) and 60-100 s (delayed) after injection of 120 mL of contrast medium at an injection rate of 6 mL/s through a preset 5-Fr catheter positioned in the celiac trunk. Spiral CT scans were assessed for enhancing pattern of the normal gastric wall, tumor detectability, and accuracy of tumor staging. RESULTS: Normal gastric mucosa was clearly visible as two or three layers in all patients on early-phase scans and in eight patients on delayed-phase scans. The primary tumors were correctly detected with CTGA in seven (88%) of the eight early gastric cancers and in all 13 (100%) advanced gastric cancers. The accuracy of CTGA for T staging was 50% and 77% in early and advanced gastric cancers, respectively. The overall accuracy for tumor detection and T staging was 95% and 67%, respectively. The accuracy of CTGA for the degree of serosal invasion and regional lymph node metastasis was 77% and 76%, respectively. CONCLUSION: The CTGA technique improved tumor detection rate and accuracy of tumor staging, especially in early gastric cancer, and may be very useful in the preoperative staging of gastric cancer.
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Angiografía , Neoplasias Gástricas/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Invasividad Neoplásica , Estadificación de Neoplasias , Estudios Prospectivos , Sensibilidad y Especificidad , Neoplasias Gástricas/irrigación sanguínea , Neoplasias Gástricas/patología , Neoplasias Gástricas/cirugíaRESUMEN
AIM: To evaluate findings of arterioportal shunts not directly related to hepatocellular carcinoma (HCC) which were seen within third-order portal branches on computed tomography (CT) during hepatic arteriography (CTHA), arterial portography (CTAP), and dual phase spiral CT. MATERIALS AND METHODS: At CTHA in 112 patients, we examined third-order portal vein branches to find arterioportal shunts not directly related to HCC. Six cases were found. We evaluated the findings of these shunts on CTHA and investigated whether CTAP (n = 6) and dual phase spiral CT (n = 5) showed perfusion defects in the corresponding areas on arterioportal shunts. RESULTS: Five of six cases showed abrupt visualization of portal branches without visualization of the proximal portion of CTHA. Five of six cases showed no perfusion defect on CTAP and no hyperattenuating area on CTHA. Four of five cases showed no hyperattenuating area on hepatic arterial phase spiral CT. CONCLUSION: Arterioportal shunts not directly related to HCC and occuring within third-order portal branches mainly showed abrupt visualization of portal branches on CTHA. These occurred frequently without perfusion defects on CTAP and without a hyperattenuating area on CTHA and hepatic arterial phase spiral CT.Park, C. M. (2000). Clinical Radiology55, 465-470.
Asunto(s)
Fístula Arteriovenosa/diagnóstico por imagen , Carcinoma Hepatocelular/diagnóstico por imagen , Arteria Hepática/anomalías , Cirrosis Hepática/diagnóstico por imagen , Neoplasias Hepáticas/diagnóstico por imagen , Vena Porta/anomalías , Tomografía Computarizada por Rayos X/métodos , Adulto , Anciano , Fístula Arteriovenosa/etiología , Carcinoma Hepatocelular/irrigación sanguínea , Carcinoma Hepatocelular/complicaciones , Medios de Contraste/administración & dosificación , Femenino , Arteria Hepática/diagnóstico por imagen , Humanos , Cirrosis Hepática/complicaciones , Neoplasias Hepáticas/irrigación sanguínea , Neoplasias Hepáticas/complicaciones , Masculino , Persona de Mediana Edad , Vena Porta/diagnóstico por imagen , Portografía/métodosRESUMEN
We are reporting two cases of pancreatic adenocarcinoma that showed dense contrast enhancement on the early phase spiral CT scan and isodensity on the delayed phase scan. Both lesions were located in the head portion of the pancreas, with diameters of 2 cm and 5 cm, respectively. Despite its extremely rare incidence, adenocarcinoma may be included in the differential diagnosis of enhanced pancreatic tumor on early-phase spiral CT scan.