RESUMEN
Two clinical trials were conducted, one involving 273 subjects with experimental rhinovirus colds and the other involving 281 subjects with natural colds. Symptomatic volunteers were randomized to receive oral lozenges containing zinc gluconate (13.3 mg), zinc acetate (5 or 11.5 mg), or placebo. The median duration of illness in zinc gluconate recipients was 2.5 days, contrasted with 3.5 days in the placebo recipients (P=.035), in the experimental colds study. Zinc gluconate had no effect on symptom severity and zinc acetate had no effect on either duration or severity. Neither formulation had an effect on the duration or severity of natural cold symptoms. Evaluation of blinding, taste, and adverse events revealed no significant differences among the 4 treatment arms. Zinc compounds appear to have little utility for common-cold treatment.
Asunto(s)
Resfriado Común/tratamiento farmacológico , Gluconatos/uso terapéutico , Acetato de Zinc/uso terapéutico , Zinc/uso terapéutico , Adolescente , Adulto , Anciano , Resfriado Común/patología , Resfriado Común/virología , Método Doble Ciego , Gluconatos/efectos adversos , Cefalea/inducido químicamente , Humanos , Persona de Mediana Edad , Náusea/inducido químicamente , Rhinovirus/efectos de los fármacos , Índice de Severidad de la Enfermedad , Factores de Tiempo , Zinc/efectos adversos , Acetato de Zinc/efectos adversosRESUMEN
A randomized study of polymyxin B sulfate-bacitracin zinc-neomycin sulfate versus simple gauze-type dressings in dermabrasion wounds assessed the effects that each treatment had on scarring. Each of three uniform dermabrasion wounds created on the upper backs of 70 subjects was treated concurrently with a triple-antibiotic ointment (polymyxin B-bacitracin-neomycin), a double antibiotic (polymyxin B-bacitracin), or a simple, non-occlusive, gauze-type dressing, twice daily for up to 14 days. Pigmentary changes and textural changes (scarring) appearing after healing at the skin surface test sites were compared to adjacent normal skin at 45 and 90 days post-dermabrasion. These changes were graded visually utilizing fluorescent light, long-wave ultraviolet light, and by clinical color photography. The triple-antibiotic ointment was superior to simple gauze-type dressing alone in minimizing the scarring observed in dermabrasion wounds. The benefit of this new ointment was more pronounced in its effect on pigmentary changes.