RESUMEN
One hundred and twenty-six patients with LE were studied. They were distributed as follows: 84 with DLE, 13 with SALE and 29 with SLE. Biopsies from the skin lesions were performed and submitted to DIF. Positive results were equal to 69, 61.5 and 72.4 percent of the DLE, SALE and SLE cases, respectively. These data are in accordance with the literature. IgM was the most frequently found immunoglobulin, followed by the association IgM + C3.
Asunto(s)
Inmunoglobulinas/sangre , Lupus Eritematoso Cutáneo/inmunología , Lupus Eritematoso Discoide/inmunología , Lupus Eritematoso Sistémico/inmunología , Adolescente , Adulto , Anciano , Niño , Femenino , Técnica del Anticuerpo Fluorescente Directa , Humanos , Lupus Eritematoso Cutáneo/diagnóstico , Lupus Eritematoso Discoide/diagnóstico , Lupus Eritematoso Sistémico/diagnóstico , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , Sensibilidad y EspecificidadRESUMEN
We describe a woman with sclerotic and atrophic lesions of the breast. Histopathologic and immunologic findings indicated a diagnosis of lupus erythematosus. Lupus mastitis is a rare presentation of panniculitis; only a few cases have been reported in the literature.
Asunto(s)
Mastitis/diagnóstico , Paniculitis de Lupus Eritematoso/diagnóstico , Adulto , Femenino , Humanos , Mastitis/complicaciones , Mastitis/inmunología , Paniculitis de Lupus Eritematoso/complicaciones , Paniculitis de Lupus Eritematoso/inmunologíaRESUMEN
Biopsy specimens of cutaneous discoid lesions of 71 patients with cutaneous lupus erythematosus (CLE) were studied. The material was examined by direct immunofluorescence (DIF) to establish positivity and morphologic patterns of immunoglobulins and complement deposits in the basement membrane zone (BMZ). A correlation between DIF results and thickening of the epidermis basement membrane (BM) stained by periodic acid-Schiff (PAS), obtained from 31 matched biopsy specimens, also is presented. Direct immunofluorescence had positive results in 66.20% of the 71 examinations and 70.97% of the matched examinations, whereas PAS showed BM thickening in 100% of the specimens. This observation stresses the importance of such histopathologic findings in the diagnosis of discoid lesions in CLE. There was no correlation between DIF patterns and PAS-stained BMZ thickening. These findings merit additional study. In conclusion, an accordance between PAS-stained BM thickening and immunoglobulin deposits has occurred in 70.97% of cases. This phenomenon does not depend on the presence of immunocomplexes, for it occurs even in cases in which immunocomplex deposits were not detected.