Asunto(s)
Hiperostosis/complicaciones , Meningioma/diagnóstico , Hueso Occipital , Neoplasias Craneales/diagnóstico , Anciano , Diagnóstico Diferencial , Femenino , Humanos , Meningioma/patología , Meningioma/cirugía , Neoplasias Craneales/patología , Neoplasias Craneales/cirugía , Tomografía Computarizada por Rayos XRESUMEN
Chordoid gliomas are uncommon primary brain tumors that arise in the region of the third ventricle. Reports of this entity to date have been limited to adults. We present a case of a chordoid glioma arising in the hypothalamic/third ventricle region of a 12-year-old male who presented with visual symptoms. The neoplasm consisted of cords and clusters of well-differentiated, spindled-to-rounded cells containing abundant eosinophilic cytoplasm within a prominent mucinous matrix. Unlike other chordoid gliomas, this lesion contained islands and sheets showing cartilaginous differentiation intermixed with the glial component. A graded transition between neoplastic glial and chondroid regions was evident, and cells in both regions were strongly immunoreactive for GFAP and S-100. Cartilaginous metaplasia is infrequent in gliomas, but occurs most often in pediatric neoplasms of the midline such as this chordoid glioma. Thus, chondroid metaplasia represents an unusual histopathologic feature of chordoid glioma-in this case, presenting in a child.
Asunto(s)
Neoplasias Encefálicas/patología , Glioma/patología , Antígenos Nucleares , Neoplasias Encefálicas/química , Neoplasias Encefálicas/cirugía , Cartílago/patología , Niño , Proteína Ácida Fibrilar de la Glía/análisis , Glioma/química , Glioma/cirugía , Humanos , Hipotálamo/patología , Inmunohistoquímica , Imagen por Resonancia Magnética , Masculino , Metaplasia , Proteínas Nucleares/análisis , Proteínas S100/análisis , Tercer Ventrículo/patologíaRESUMEN
This case of neurosarcoidosis of the spinal cord involved several meningeal areas and spinal cord levels. It appears to be the tenth autopsy-documented case of neurosarcoidosis of the spinal cord, though the patient had more extensive spinal cord disease than has been previously reported.
Asunto(s)
Sarcoidosis/patología , Enfermedades de la Médula Espinal/patología , Adulto , Antiinflamatorios/uso terapéutico , Aracnoides , Autopsia , Diagnóstico Diferencial , Resultado Fatal , Humanos , Masculino , Paraplejía/etiología , Piamadre , Sarcoidosis/complicaciones , Sarcoidosis/tratamiento farmacológico , Enfermedades de la Médula Espinal/complicaciones , Enfermedades de la Médula Espinal/tratamiento farmacológico , EsteroidesRESUMEN
Chordoid glioma of the third ventricle is a recently characterized primary neoplasm of the central nervous system. We present a case and discuss the pathologic and radiologic features. We are aware of only 16 other cases documented in the world literature. This radiologic-pathologic correlation alerts pathologists and radiologists to recognize chordoid glioma as a distinct clinicopathologic entity restricted to the third ventricular area of adult patients.
Asunto(s)
Neoplasias del Plexo Coroideo/patología , Glioma/patología , Tercer Ventrículo/patología , Adulto , Biomarcadores de Tumor/metabolismo , Encéfalo/diagnóstico por imagen , Neoplasias del Plexo Coroideo/química , Neoplasias del Plexo Coroideo/diagnóstico por imagen , Glioma/química , Glioma/diagnóstico por imagen , Humanos , Inmunohistoquímica , Imagen por Resonancia Magnética , Masculino , Proteínas de Neoplasias/metabolismo , Tercer Ventrículo/diagnóstico por imagen , Tomografía Computarizada por Rayos XRESUMEN
We report a case of predominantly intraductal carcinoma of the pancreas with microscopic foci of invasive carcinoma in a patient with chronic pancreatitis. In this article, we discuss the pathologic and prognostic features of pancreatic carcinoma in situ. This entity is probably overlooked due to a number of reasons, including the fact that, in most cases, pancreatic ductal carcinomas are extensively infiltrative at the time of surgical removal; the atypical epithelial changes in the intraductal carcinoma had been overlooked in the presence or absence of an invasive component; epithelial changes may be missed due to insufficient sampling; and last, the differentiation with atypical epithelial hyperplasia is a subjective matter. Intraductal carcinoma of the pancreas is a distinct pathological entity with characteristic morphologic changes restricted to the ductal epithelium, bearing important prognostic implications.