RESUMEN
Five liver injury measures (albumin, prothrombin time, gamma globulin, indocyanine green clearance and serum ammonia) were correlated with neuropsychologic test performance in a group of 79 nonalcoholic cirrhotic patients. Employing linear regression analysis techniques revealed that these five measures, particularly albumin and prothrombin time, could explain a significant amount of the variance on neuropsychological tests. The results indicate that functional liver status, even where there is no overt evidence of hepatic encephalopathy, is related to cognitive capacity.
Asunto(s)
Cirrosis Hepática/psicología , Trastornos Mentales/complicaciones , Enfermedades del Sistema Nervioso/complicaciones , Adulto , Cognición/fisiología , Femenino , Humanos , Pruebas de Inteligencia , Cirrosis Hepática/complicaciones , Pruebas de Función Hepática , Masculino , Persona de Mediana Edad , Desempeño Psicomotor/efectos de los fármacos , Análisis de RegresiónRESUMEN
Visual, auditory and somatosensory event related potentials were recorded from 58 patients with chronic nonalcoholic liver disease. The results of this study indicate that a significant, although somewhat modest, amount of variance on brainstem auditory, pattern visual and somatosensory ERP latency can be predicted by routinely obtained liver functional measures, albumin, prothrombin time, fasting ammonia level, globulin and especially indocyanine green clearance. Moreover, these associations are present in persons who are not overtly encephalopathic, underscoring the sensitivity of neurophysiologic measurement for detecting hepatic encephalopathy concomitant to only moderate severity of hepatic injury.