RESUMEN
Epidural anaesthesia is an effective form of pain relief during vaginal deliveries. However, neuraxial anaesthesia may slow the progression of labour. The assumption that epidurals lead to increased caesarean sections is also a topic of current debate. A holistic approach with the use of a birthing ball has been advocated as a potential modality to decrease labouring times and, therefore, reduce progression to caesarean section. Birthing balls aim to increase pelvic outlet opening, which facilitates labouring. Our aim is to review recent literature pertaining to birthing balls and their role in improving quality and outcomes of vaginal deliveries in patients with epidurals.IMPACT STATEMENTWhat is already known on the subject? Epidural anaesthesia may slow the progression of labour. It has been hypothesised that slowing progression of labour is associated with increased rates of vacuum and forceps delivery. Most common clinical indication for caesarean section is failure to progress during labour. Birthing Balls have been shown to quicken the progression of labour, theoretically reducing caesarean sections with those with epidurals.What do the results of the study add? Several studies have demonstrated a reduced duration of first and second stage of labour among women with epidural anaesthesia, but the existing literature is limited, and interpretation of results may be restricted by generalizability and inherent study biases. The objective of this article is to review existing literature and highlight the potential clinical utility of birthing balls in current obstetric practice.What are the implications of these findings for clinical practice and further research? Use of birthing balls has been advocated to decrease labouring time and therefore reduce progression to caesarean section. Larger studies or meta-analysis would be required to confirm potential benefits of birthing ball use.
Asunto(s)
Analgesia Obstétrica , Anestesia Epidural , Parto Obstétrico/métodos , Distocia , Posicionamiento del Paciente , Esfuerzo de Parto , Analgesia Obstétrica/efectos adversos , Analgesia Obstétrica/métodos , Anestesia Epidural/efectos adversos , Anestesia Epidural/métodos , Cesárea/métodos , Cesárea/estadística & datos numéricos , Distocia/inducido químicamente , Distocia/prevención & control , Femenino , Humanos , Posicionamiento del Paciente/instrumentación , Posicionamiento del Paciente/métodos , EmbarazoRESUMEN
BACKGROUND: Individuals with hypertrophic cardiomyopathy (HCM), even when asymptomatic, are at-risk for sudden cardiac death and stroke from arrhythmias, making it imperative to identify individuals affected by this familial disorder. Consensus guidelines recommend that first-degree relatives (FDRs) of a person with HCM undergo serial cardiovascular evaluations. METHODS: We determined the uptake of family screening in patients with HCM and developed an online video intervention to facilitate family communication and screening. Family screening and genetic testing data were collected through a prospective quality improvement initiative, a standardized clinical assessment and management plan (SCAMP), utilized in an established cardiovascular genetics clinic. Patients were prescribed an online video if screening of their FDRs was incomplete and a pilot study on video utilization and family communication was conducted. RESULTS: Two-hundred and sixteen probands with HCM were enrolled in SCAMP Phase I and 190 were enrolled in SCAMP Phase II. In both phases, probands reported that 51% of FDRs had been screened (382/749 in Phase I, 258/504 in Phase II). Twenty patients participated in a pilot study on video utilization and family communication. Nine participants reported watching the video and six participants reported sharing the video with relatives; however only one participant reported sharing the video with relatives who were not yet aware of the diagnosis of HCM in the family. CONCLUSION: Despite care in a specialized cardiovascular genetics clinic, approximately one half of FDRs of patients with HCM remained unscreened. Online interventions and videos may serve as supplemental tools for patients communicating genetic risk information to relatives.
Asunto(s)
Cardiomiopatía Hipertrófica/diagnóstico , Predisposición Genética a la Enfermedad , Pruebas Genéticas/métodos , Educación en Salud/métodos , Tamizaje Masivo/psicología , Sistemas en Línea , Participación del Paciente/psicología , Cardiomiopatía Hipertrófica/genética , Cardiomiopatía Hipertrófica/psicología , Familia , Femenino , Estudios de Seguimiento , Pruebas Genéticas/tendencias , Comunicación en Salud , Promoción de la Salud/métodos , Humanos , Masculino , Tamizaje Masivo/estadística & datos numéricos , Persona de Mediana Edad , Aceptación de la Atención de Salud , Participación del Paciente/estadística & datos numéricos , Proyectos Piloto , Pronóstico , Estudios ProspectivosRESUMEN
Divergence times for species assemblages of Arctic marine invertebrates have often been estimated using a standard rate (1.4%/MY) of molecular evolution calibrated using a single sister pair of tropical crustaceans. Because rates of molecular evolution vary among taxa and environments, it is essential to obtain clock calibrations from northern lineages. The recurrent opening and closure of the Bering Strait provide an exceptional opportunity for clock calibration. Here, we apply the iterative calibration approach to investigate patterns of molecular divergence among lineages of northern marine molluscs and arthropods using publicly available sequences of the cytochrome c oxidase subunit I (COI) gene and compare these results with previous estimates of trans-Bering divergences for echinoderms and polychaetes. The wide range of Kimura two-parameter (K2P) divergences among 73 trans-Bering sister pairs (0.12%-16.89%) supports multiple pulses of migration through the Strait. Overall, the results indicate a rate of K2P divergence of 3.2%/MY in molluscs, 5%-5.2%/MY in arthropods, and 3.5%-4.7%/MY in polychaetes. While these rates are considerably higher than the often-adopted 1.4%/MY rate, they are similar to calibrations (3%-5%/MY) in several other studies of marine invertebrates. This upward revision in rates means there is a need both to reevaluate the evolutionary history of marine lineages and to reexamine the impact of prior climatic changes upon the diversification of marine life.
Asunto(s)
Artrópodos/genética , Código de Barras del ADN Taxonómico/métodos , ADN/genética , Evolución Molecular , Variación Genética , Moluscos/genética , Poliquetos/genética , Animales , ADN/análisis , Complejo IV de Transporte de Electrones/genética , FilogeniaRESUMEN
Background Cardiology has advanced guideline development and quality measurement. Recognizing the substantial benefits of guideline-directed medical therapy, this study aims to measure and explain apparent deviations in heart failure ( HF ) guideline adherence by clinicians at hospital discharge and describe any impact on readmission rates. Methods and Results The extent of decongestion and prescription of neurohormonal therapy were recorded prospectively for 226 HF discharges, including 132 (58%) from an academic hospital and 94 (42%) from a community hospital. Among all discharges, 25% were discharged with residual congestion (30% academic versus 18% community, P=0.070). Among discharges of patients with HF with reduced ejection fraction, 37% (45% academic versus 18% community, P<0.001) were discharged without ß-blocker therapy or with lower doses than at admission. Moreover, 46% of patients with HF with reduced ejection fraction (48% academic versus 39% community, P=0.390) were discharged without an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker or with lower doses than at admission. Renal dysfunction was the most common reason for discharge with congestion, and hypotension the most common reason for discharge with no or decreased neurohormonal therapy. There was a trend toward higher 90-day readmission rates after discharge with residual congestion. Conclusions Clinicians frequently deviate from guidelines in both academic and community hospitals; however, this deviation may not always indicate poor quality. Application of guidelines recommended for stable populations is increasingly limited for hospitalized patients by hypotension, renal dysfunction, and inotrope use. Patients with renal dysfunction, hypotension, and recent inotrope use merit further study to determine best practices and possibly to adjust quality metrics for HF severity.
Asunto(s)
Edema Cardíaco/terapia , Adhesión a Directriz , Insuficiencia Cardíaca/terapia , Guías de Práctica Clínica como Asunto , Centros Médicos Académicos , Antagonistas Adrenérgicos beta/uso terapéutico , Anciano , Bloqueadores del Receptor Tipo 2 de Angiotensina II/uso terapéutico , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Comorbilidad , Edema Cardíaco/epidemiología , Edema Cardíaco/etiología , Edema Cardíaco/fisiopatología , Femenino , Insuficiencia Cardíaca/complicaciones , Insuficiencia Cardíaca/epidemiología , Insuficiencia Cardíaca/fisiopatología , Hospitales Comunitarios , Humanos , Hipotensión/epidemiología , Masculino , Persona de Mediana Edad , Readmisión del Paciente/estadística & datos numéricos , Calidad de la Atención de Salud , Insuficiencia Renal/epidemiología , Volumen Sistólico/fisiologíaRESUMEN
PURPOSE: Previous research has investigated changes in athletes' strength, power, and speed performances across the competitive season of many sports, although this has not been explored in cricketers. The aim of this study was to investigate changes in lower-body strength and jump and sprint performances across an English county cricket season. METHODS: Male cricketers (N = 12; age 24.4 ± 2.3 y, body mass 84.3 ± 9.9 kg, height 184.1 ± 8.1 cm) performed countermovement jumps (CMJs) and 20-m sprints on 4 separate occasions and back-squat strength testing on 3 separate occasions across a competitive season. RESULTS: Both absolute (12.9%, P = .005, effect size [ES] = 0.53) and relative lower-body strength (15.8%, P = .004, ES = 0.69) and CMJ height (5.3%, P = .037, ES = 0.42) improved significantly over the preseason training period, although no significant change (1.7%, P > .05) in sprint performance was observed. In contrast, absolute (14.3%, P = .001, ES = 0.72) and relative strength (15.0%, P = .001, ES = 0.77), CMJ height (4.2%, P = .023, ES = 0.40), and sprint performance (3.8%, P = .012, ES = 0.94) declined significantly across the season. CONCLUSIONS: The results of this study show that neither the demands of the competitive cricket season nor current in-season training practices provide a sufficient stimulus to maintain strength, jump, and sprint performances in these cricketers. Therefore, coaches should implement a more-frequent, higher-load strength-training program across the competitive cricket season.
Asunto(s)
Rendimiento Atlético/fisiología , Conducta Competitiva/fisiología , Fuerza Muscular/fisiología , Estaciones del Año , Deportes/fisiología , Índice de Masa Corporal , Prueba de Esfuerzo , Humanos , Masculino , Entrenamiento de Fuerza , Adulto JovenRESUMEN
OBJECTIVES: Chest pain is a common complaint in the emergency department, and a small but important minority represents an acute coronary syndrome (ACS). Variation in diagnostic workup, risk stratification, and management may result in underuse, misuse, and/or overuse of resources. METHODS: From July to October 2014, we conducted a prospective cohort study in an academic medical center by implementing a Standardized Clinical Assessment and Management Plan (SCAMP) for chest pain based on the HEART score. In addition to capturing adherence to the SCAMP algorithm and reasons for any deviations, we measured troponin sample timing; rates of stress test utilization; length of stay (LOS); and 30-day rates of revascularization, ACS, and death. RESULTS: We identified 239 patients during the enrollment period who were eligible to enter the SCAMP, of whom 97 patients were entered into the pathway. Patients were risk stratified into one of 3 risk tiers: high (n = 3), intermediate (n = 40), and low (n = 54). Among low-risk patients, recommendations for troponin testing were not followed in 56%, and 11% received stress tests contrary to the SCAMP recommendation. None of the low-risk patients had elevated troponin measurements, and none had an abnormal stress test. Mean LOS in low-risk patients managed with discordant plans was 22:26 h/min, compared with 9:13 h/min in concordant patients (P < 0.001). Mean LOS in intermediate-risk patients with stress testing was 25:53 h/min, compared with 7:55 h/min for those without (P < 0.001). At 30 days, 10% of intermediate-risk patients and 0% of low-risk patients experienced an ACS event (risk difference 10% [0.7%-19%]); none experienced revascularization or death. The most frequently cited reason for deviation from the SCAMP was lack of confidence in the tool. CONCLUSIONS: Compliance with SCAMP recommendations for low- and intermediate-risk patients was poor, largely due to lack of confidence in the tool. However, in our study population, outcomes suggest that deviation from the SCAMP yielded no additional clinical benefit while significantly prolonging emergency department LOS.
Asunto(s)
Síndrome Coronario Agudo/complicaciones , Dolor en el Pecho/epidemiología , Vías Clínicas/normas , Manejo de la Enfermedad , Mejoramiento de la Calidad , Medición de Riesgo , Síndrome Coronario Agudo/diagnóstico , Síndrome Coronario Agudo/terapia , Anciano , Algoritmos , Dolor en el Pecho/diagnóstico , Dolor en el Pecho/terapia , Toma de Decisiones , Electrocardiografía , Servicio de Urgencia en Hospital , Prueba de Esfuerzo , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Prospectivos , Factores de RiesgoRESUMEN
OBJECTIVE: Placental-site trophoblastic tumor (PSTT) is the rarest form of gestational trophoblastic disease (GTD). A risk-adapted treatment approach has been advocated, but controversy exists as to the most important prognostic markers for this disease. Our goal was to determine the prognostic markers for patients with PSTT seen at our center. METHODS: We conducted a retrospective analysis of patients with PSTT seen at a single tertiary care center between 1996 and 2011. The association of FIGO stage, interval from antecedent pregnancy, antecedent pregnancy outcome, human chorionic gonadotropin (hCG) level, and age to overall survival was examined using univariate log-rank tests. Presentation, treatment, and outcome were summarized using descriptive statistics. RESULTS: Data from 17 patients were analyzed. Eight (47%) had Stage I/II disease and 9 (53%) had Stage III/IV disease. Median overall survival for the entire cohort was 86 months (range, 2-101 months). Median duration of follow-up for surviving patients was 56 months. Increasing FIGO stage (I-III versus IV) was associated with a worse overall survival (p=0.009). Interval from antecedent pregnancy (≥12months), antecedent pregnancy outcome (full-term), hCG (≥1000 IU/L), and age (≥40) were not associated with worse survival. CONCLUSION: FIGO stage, specifically Stage IV disease, was the most important predictor of overall survival in our cohort of PSTT patients.
Asunto(s)
Tumor Trofoblástico Localizado en la Placenta/patología , Neoplasias Uterinas/patología , Adulto , Femenino , Humanos , Neoplasias Pulmonares/secundario , Estadificación de Neoplasias , Embarazo , Pronóstico , Estudios Retrospectivos , Tumor Trofoblástico Localizado en la Placenta/mortalidad , Tumor Trofoblástico Localizado en la Placenta/terapia , Neoplasias Uterinas/mortalidad , Neoplasias Uterinas/terapiaRESUMEN
BACKGROUND: Although polychaetes are one of the dominant taxa in marine communities, their distributions and taxonomic diversity are poorly understood. Recent studies have shown that many species thought to have broad distributions are actually a complex of allied species. In Canada, 12% of polychaete species are thought to occur in Atlantic, Arctic, and Pacific Oceans, but the extent of gene flow among their populations has not been tested. METHODOLOGY/PRINCIPAL FINDINGS: Sequence variation in a segment of the mitochondrial cytochrome c oxidase I (COI) gene was employed to compare morphological versus molecular diversity estimates, to examine gene flow among populations of widespread species, and to explore connectivity patterns among Canada's three oceans. Analysis of 1876 specimens, representing 333 provisional species, revealed 40 times more sequence divergence between than within species (16.5% versus 0.38%). Genetic data suggest that one quarter of previously recognized species actually include two or more divergent lineages, indicating that richness in this region is currently underestimated. Few species with a tri-oceanic distribution showed genetic cohesion. Instead, large genetic breaks occur between Pacific and Atlantic-Arctic lineages, suggesting their long-term separation. High connectivity among Arctic and Atlantic regions and low connectivity with the Pacific further supports the conclusion that Canadian polychaetes are partitioned into two distinct faunas. CONCLUSIONS/SIGNIFICANCE: Results of this study confirm that COI sequences are an effective tool for species identification in polychaetes, and suggest that DNA barcoding will aid the recognition of species overlooked by the current taxonomic system. The consistent geographic structuring within presumed widespread species suggests that historical range fragmentation during the Pleistocene ultimately increased Canadian polychaete diversity and that the coastal British Columbia fauna played a minor role in Arctic recolonization following deglaciation. This study highlights the value of DNA barcoding for providing rapid insights into species distributions and biogeographic patterns in understudied groups.