RESUMEN

To determine the natural history of mesangial proliferative glomerulonephritis (MesPGN) with IgM deposits and its relationship to minimal change disease (MC) and focal segmental glomerulosclerosis (FGS), we studied the clinical characteristics and outcome in 20 patients with MesPGN, 8 with MC, and 10 with FGS. IgM deposits were present in glomeruli of all MesPGN patients. Progression to FGS was documented in 2 patients with MesPGN, 1 of whom developed renal failure. Transition from MC to MesPGN occurred in 1 patient. 2 MC patients developed FGS, with decline in renal function in 1 of them. These data suggest the possibility of histologic transition from MC to FGS directly or through the stage of MesPGN.

Asunto(s)

Mesangio Glomerular/patología , Glomerulonefritis/patología , Inmunoglobulina M/metabolismo , Adolescente , Adulto , Niño , Preescolar , Proteínas del Sistema Complemento/metabolismo , Femenino , Técnica del Anticuerpo Fluorescente , Mesangio Glomerular/inmunología , Glomerulonefritis/inmunología , Glomeruloesclerosis Focal y Segmentaria/inmunología , Glomeruloesclerosis Focal y Segmentaria/patología , Humanos , Inmunoglobulina A/metabolismo , Inmunoglobulina G/metabolismo , Glomérulos Renales/patología , Masculino , Microscopía Electrónica , Persona de Mediana Edad , Nefrosis Lipoidea/inmunología , Nefrosis Lipoidea/patología , Properdina/metabolismo

Asunto(s)

Antibacterianos/efectos adversos , Gentamicinas/efectos adversos , Riñón/efectos de los fármacos , Tobramicina/efectos adversos , Acetilglucosaminidasa/orina , Adulto , Anciano , Creatinina/sangre , Método Doble Ciego , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Distribución Aleatoria , Microglobulina beta-2/orina