RESUMEN
This case study describes a 71-year-old man with signet-ring cell gastric adenocarcinoma and malignant sigmoidal polyp; and typical features of Saint's triad and Heyde syndrome. He had digestive bleeding, two types of hernia, diverticulosis, arterial hypertension, malignant polyp, and antecedent of smoking, lung tuberculosis, and surgical correction of aortic valve stenosis. There is a hypothetical inverse relationship between herniosis and development of malignancy; however, the patient herein described presented gastric and sigmoidal cancers. Gastrointestinal malignancies are sometimes associated with paraneoplastic entities, isolated or manifested as syndromes, but neither Saint's triad or Heyde syndrome have been included. This patient persisted clinically stable during the preoperative period, but suddenly died; Trousseau's syndrome would be the most probable mechanism of sudden death in this setting. Case reports can stimulate further studies to get additional knowledge about unusual entities.
Asunto(s)
Estenosis de la Válvula Aórtica/complicaciones , Carcinoma de Células en Anillo de Sello/complicaciones , Colelitiasis/complicaciones , Pólipos del Colon/complicaciones , Divertículo/complicaciones , Hemorragia Gastrointestinal/etiología , Hernia Hiatal/complicaciones , Neoplasias Primarias Múltiples/complicaciones , Neoplasias del Colon Sigmoide/complicaciones , Neoplasias Gástricas/complicaciones , Anciano , Anemia Ferropénica/etiología , Angiodisplasia/etiología , Muerte Súbita , Resultado Fatal , Humanos , Masculino , Modelos Biológicos , Síndrome , Tromboflebitis/etiologíaRESUMEN
This case study describes a 71-year-old man with signet-ring cell gastric adenocarcinoma and malignant sigmoidal polyp; and typical features of Saint's triad and Heyde syndrome. He had digestive bleeding, two types of hernia, diverticulosis, arterial hypertension, malignant polyp, and antecedent of smoking, lung tuberculosis, and surgical correction of aortic valve stenosis. There is a hypothetical inverse relationship between herniosis and development of malignancy; however, the patient herein described presented gastric and sigmoidal cancers. Gastrointestinal malignancies are sometimes associated with paraneoplastic entities, isolated or manifested as syndromes, but neither Saint's triad or Heyde syndrome have been included. This patient persisted clinically stable during the preoperative period, but suddenly died; Trousseau's syndrome would be the most probable mechanism of sudden death in this setting. Case reports can stimulate further studies to get additional knowledge about unusual entities.
Este estudio de caso describe un hombre de 71 años de edad, con adenocarcinoma gástrico con células en anillo de sello y un pólipo maligno sigmoideo; y características típicas de la tríada de Saint y del síndrome de Heyde. Tuvo una hemorragia digestiva, dos tipos de hernias, divertículos, hipertensión arterial, y pólipo maligno; con antecedente de tabaquismo, tuberculosis pulmonar, y corrección quirúrgica de estenosis de la válvula aórtica. Hay una hipotética relación inversa entre hernioses y el desarrollo de malignidades; sin embargo, el paciente que se describe en el presente documento presentó cánceres gástrico y sigmoideo. Neoplasias gastrointestinales se asocian a veces con entidades para neoplásicas aisladas o manifiestan síndromes, pero ni la tríada de Saint ni el síndrome de Heyde se ha incluido. Este paciente persistió clínicamente estable durante el período preoperatorio, pero de repente murió; síndrome de Trousseau sería el mecanismo más probable de muerte súbita en esta situación. Los informes de casos pueden estimular más estudios para obtener un conocimiento adicional sobre esas entidades inusuales.
Asunto(s)
Anciano , Humanos , Masculino , Estenosis de la Válvula Aórtica/complicaciones , Neoplasias del Colon Sigmoide/complicaciones , Neoplasias Gástricas/complicaciones , Colelitiasis/complicaciones , Pólipos del Colon/complicaciones , Divertículo/complicaciones , Carcinoma de Células en Anillo de Sello/complicaciones , Hemorragia Gastrointestinal/etiología , Hernia Hiatal/complicaciones , Neoplasias Primarias Múltiples/complicaciones , Síndrome , Tromboflebitis/etiología , Angiodisplasia/etiología , Resultado Fatal , Anemia Ferropénica/etiología , Muerte Súbita , Modelos BiológicosRESUMEN
BACKGROUND: Conflicting results have been reported in studies evaluating the relationship between serum markers of iron overload, liver iron deposits, and HFE mutations (C282Y and H63D) in chronic hepatitis C patients, and also their impact on the response to therapy in these patients. AIM: To evaluate the role of HFE mutations in the severity of liver disease and in the response to therapy in chronic hepatitis C. METHODS: Two hundred and sixty-four hepatitis C patients treated with standard interferon and ribavirin were divided into two groups according to type of antiviral response: sustained virological response (SVR) and nonresponse or relapse. We evaluated the relationship between HFE mutation and the type of antiviral response, clinical data, biochemical tests, liver histopathology, virological data, and HFE mutations. RESULTS: Of the 264 patients, 88 (32.1%) had SVR whereas 67.9% had nonresponse or relapse. Liver iron deposits were observed in 49.2% of the patients. The factors associated with SVR were hepatitis C virus genotype 2 or 3, transferrin saturation value of 45% or less, and detection of the H63D mutation. HFE mutation was more frequent in patients with iron deposits, but without association with serum iron biochemistry or severity of liver disease. Steatosis was more frequent in patients with liver iron deposits. CONCLUSION THE: H63D mutation was an independent factor associated with SVR in chronic hepatitis C patients, as also were hepatitis C virus genotype 2 or 3 and transferrin saturation value of 45% or less. Moreover, the H63D mutation was associated with liver iron deposits.
Asunto(s)
Farmacorresistencia Viral/genética , Hepatitis C Crónica , Antígenos de Histocompatibilidad Clase I/genética , Interferón-alfa/uso terapéutico , Proteínas de la Membrana/genética , Ribavirina/uso terapéutico , Adulto , Antivirales/uso terapéutico , Femenino , Variación Genética , Genotipo , Proteína de la Hemocromatosis , Hepatitis C Crónica/tratamiento farmacológico , Hepatitis C Crónica/epidemiología , Hepatitis C Crónica/genética , Humanos , Interferón alfa-2 , Hierro/metabolismo , Hígado/metabolismo , Masculino , Prevalencia , Proteínas Recombinantes , Estudios Retrospectivos , Factores de RiesgoRESUMEN
As doenças hepáticas crônicas, em fases avançadas, cursam com graves complicações, responsáveis pela maioria das indicações de internações hospitalares e causas de morte dos pacientes. Neste capítulo, são discutidas as principais complicações das doenças hepáticas crônicas, que são a encefalopatia hepática, a peritonite bacteriana espontânea e a síndrome hepatorrenal. São apresentados os aspectos importantes, na prática médica, dessas três condições clínicas, com ênfase na abordagem diagnóstica e terapêutica
Asunto(s)
Humanos , Masculino , Femenino , Encefalopatía Hepática/complicaciones , Encefalopatía Hepática/diagnóstico , Encefalopatía Hepática/terapiaRESUMEN
Objective - To evaluate the use of the intraaortic balloon (IaoB) in association with coronary angioplasty in high-risk patients. Methods - Fourteen high-risk patients unresponsive to clinical therapy and with formal contraindication to surgical revascularization were treated by coronary angioplasty, most of which was followed by stenting. All procedures were performed with circulatory support with the IaoB. This study reports the early results and the late findings after 12 months of follow-up. Six patients had multivessel coronary disease; of these, four had left main equivalent lesions and two had unprotected left main coronary artery disease, one of whom had severe "endvessel" stenosis and the other was a patient with Chagas' disease with single-vessel lesion. Eleven patients had a left ventricular ejection fraction <30 per cent. Results - In 100 per cent of the patients, the procedures were intially successful. Two patients had severe bleeding during the withdrawal of the left femoral sheath. At the of twelve months, 4 patients were asymptomatic and the others were clinically controlled. There were two late deaths in the 7th and 11th months. Conclusion - The combined use of the intraaortic balloon pump and percutaneous coronary angioplasty in high-risk patients with acute inschemic syndromes provides the necessary hemodynamic stability to seccessfully perform the procedures.