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1.
Br J Oral Maxillofac Surg ; 57(7): 632-637, 2019 09.
Artículo en Inglés | MEDLINE | ID: mdl-31200980

RESUMEN

This epidemiological study was designed to find out the incidence and factors associated with the occurrence of intraosseous lesions diagnosed at a Reference Centre in Brazil. We included all patients diagnosed with intraosseous lesions (cyst, tumour, bone-associated lesion, and periapical disease) during the period 2006-2017, and analysed the association between some sociodemographic and clinical variables and the types of lesion. There was a total of 290 intraosseous lesions, the most common being odontogenic cysts. There was a significant association between age and odontogenic tumours (p=0.001). In relation to the histopathological diagnosis, root cysts were the most common (n=57), followed by dentigerous cysts (n=26). The lesions studied were seen most often in women between the second and fourth decades of life, odontogenic cysts being the most common type found. We know of few publications of similar epidemiological work, either in Brazil or in the rest of the world, so we suggest that more such studies are made.


Asunto(s)
Quiste Dentígero/patología , Quistes Odontogénicos/epidemiología , Tumores Odontogénicos/epidemiología , Enfermedades Estomatognáticas/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Biopsia , Brasil/epidemiología , Niño , Preescolar , Quiste Dentígero/epidemiología , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Quistes Odontogénicos/patología , Tumores Odontogénicos/patología , Estudios Retrospectivos , Enfermedades Estomatognáticas/patología , Adulto Joven
2.
Br J Pharmacol ; 170(4): 835-46, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23889691

RESUMEN

BACKGROUND AND PURPOSE: AVE 0991 (AVE) is a non-peptide compound, mimic of the angiotensin (Ang)-(1-7) actions in many tissues and pathophysiological states. Here, we have investigated the effect of AVE on pulmonary remodelling in a murine model of ovalbumin (OVA)-induced chronic allergic lung inflammation. EXPERIMENTAL APPROACH: We used BALB/c mice (6-8 weeks old) and induced chronic allergic lung inflammation by OVA sensitization (20 µg·mouse(-1) , i.p., four times, 14 days apart) and OVA challenge (1%, nebulised during 30 min, three times per·week, for 4 weeks). Control and AVE groups were given saline i.p and challenged with saline. AVE treatment (1 mg·kg(-1) ·per day, s.c.) or saline (100 µL·kg(-1) ·per day, s.c.) was given during the challenge period. Mice were anaesthetized 72 h after the last challenge and blood and lungs collected. In some animals, primary bronchi were isolated to test contractile responses. Cytokines were evaluated in bronchoalveolar lavage (BAL) and lung homogenates. KEY RESULTS: Treatment with AVE of OVA sensitised and challenged mice attenuated the altered contractile response to carbachol in bronchial rings and reversed the increased airway wall and pulmonary vasculature thickness and right ventricular hypertrophy. Furthermore, AVE reduced IL-5 and increased IL-10 levels in the BAL, accompanied by decreased Ang II levels in lungs. CONCLUSIONS AND IMPLICATIONS: AVE treatment prevented pulmonary remodelling, inflammation and right ventricular hypertrophy in OVA mice, suggesting that Ang-(1-7) receptor agonists are a new possibility for the treatment of pulmonary remodelling induced by chronic asthma.


Asunto(s)
Remodelación de las Vías Aéreas (Respiratorias)/efectos de los fármacos , Angiotensina I/farmacología , Antiasmáticos/farmacología , Asma/tratamiento farmacológico , Imidazoles/farmacología , Pulmón/efectos de los fármacos , Fragmentos de Péptidos/farmacología , Arteria Pulmonar/efectos de los fármacos , Venas Pulmonares/efectos de los fármacos , Angiotensina II/metabolismo , Animales , Asma/inducido químicamente , Asma/inmunología , Asma/metabolismo , Asma/fisiopatología , Líquido del Lavado Bronquioalveolar/inmunología , Broncoconstricción/efectos de los fármacos , Enfermedad Crónica , Citocinas/metabolismo , Modelos Animales de Enfermedad , Hipertrofia Ventricular Derecha/metabolismo , Hipertrofia Ventricular Derecha/prevención & control , Pulmón/irrigación sanguínea , Pulmón/inmunología , Pulmón/metabolismo , Pulmón/fisiopatología , Masculino , Ratones , Ratones Endogámicos BALB C , Imitación Molecular , Ovalbúmina , Proto-Oncogenes Mas , Proteínas Proto-Oncogénicas/efectos de los fármacos , Proteínas Proto-Oncogénicas/metabolismo , Arteria Pulmonar/inmunología , Arteria Pulmonar/metabolismo , Arteria Pulmonar/fisiopatología , Venas Pulmonares/inmunología , Venas Pulmonares/metabolismo , Venas Pulmonares/fisiopatología , Receptores Acoplados a Proteínas G/efectos de los fármacos , Receptores Acoplados a Proteínas G/metabolismo , Factores de Tiempo
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