RESUMEN

To investigate similarities in the gene profile of Oral Lichen Planus and Oral Squamous Cell Carcinoma that may justify a carcinogenic potential, we analyzed the gene expression signatures of Oral Lichen Planus and Oral Squamous Cell Carcinoma in early and advanced stages. Based on gene expression data from public databases, we used a bioinformatics approach to compare expression profiles, estimate immune infiltrate composition, identify differentially and co-expressed genes, and propose putative therapeutic targets and associated drugs. Our results revealed gene expression patterns related to processes of keratinization, keratinocyte differentiation, cell proliferation and immune response in common between Oral Lichen Planus and early and advanced Oral Squamous Cell Carcinoma, with the cornified envelope formation and antigen processing cross-presentation pathways in common between Oral Lichen Planus and early Oral Squamous Cell Carcinoma. Together, these results reveal that key tumor suppressors and oncogenes such as PI3, SPRR1B and KRT17, as well as genes associated with different immune processes such as CXCL13, HIF1A and IL1B are dysregulated in OLP.

Asunto(s)

Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello , Liquen Plano Oral , Neoplasias de la Boca , Humanos , Neoplasias de la Boca/genética , Liquen Plano Oral/genética , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas de Cabeza y Cuello , Oncogenes , Carcinogénesis/genética

RESUMEN

The present study aimed to compare the oral Candida rate between infected and uninfected children with the human immunodeficiency virus (HIV), as well as analyze the association between Candida spp. and predisposing factors of colonization, like oral biofilm index, caries experience, and laboratory markers of AIDS progression. A cross-sectional study was employed. Candida species were identified and quantified from saliva samples of 50 HIV-infected and 50 uninfected children. Biofilm index and decayed, missing, and filled teeth (dmft/DMFT) indices were assessed by oral clinical examinations. Additionally, CD4+ T lymphocyte count and viral load were obtained from medical records of the HIV-infected children. Candida species were cultured from 74% of the HIV-infected children and 46% of uninfected ones (p = 0.0076). Candida albicans and Candida parapsilosis were the most frequently isolated species in both studied groups. The isolation of Candida species was significantly higher in HIV-infected children with CD4 ≤ 15% (p = 0.0146); it had influence of mature oral biofilm and the caries index (dmft + DMFT ≥ 8) (p < 0.05) and was associated with the plasma viral load. The present data show that the HIV infection, oral biofilm index, caries experience, and laboratory markers of AIDS progression exert an influence on the prevalence of oral Candida in children.

Asunto(s)

Síndrome de Inmunodeficiencia Adquirida , Caries Dental , Infecciones por VIH , Niño , Humanos , Infecciones por VIH/complicaciones , Candida , Estudios Transversales , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Susceptibilidad a Caries Dentarias , Biopelículas , Biomarcadores , Progresión de la Enfermedad , Caries Dental/complicaciones

RESUMEN

This review outlines the historical perspective, status, and future challenges of oral medicine (stomatology) in Brazil based on the records of the Brazilian Society of Stomatology and Oral Pathology (SOBEP) and the Brazilian Federal Dental Council as well as expert evidence input from academic leaders from 3 different generations of Brazilian oral medicine specialists. The beginning of oral medicine in Brazil dates to 1969, followed by the organization of SOBEP in 1974; however, official recognition as an independent specialty was achieved more recently within the Brazilian Federal Dental Council in 1992. After a 50-year maturation period of oral medicine in Brazil in terms of specialty crystallization across dentistry, medicine, and research, it is now time to follow the historical trends of the specialty internationally and establish a standard curriculum at a post-graduate level that will lead to uniformity of training for oral medicine in Brazil.

Asunto(s)

Medicina Oral , Brasil , Curriculum , Odontólogos , Predicción , Humanos

RESUMEN

Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The aim of this study was to discuss the risk factors for the development of MRONJ and prevention of this complication in patients with osteoporosis taking antiresorptive drugs and requiring invasive dental treatment. For this goal, a task force with representatives from three professional associations was appointed to review the pertinent literature and discuss systemic and local risk factors, prevention of MRONJ in patients with osteoporosis, and management of established MRONJ. Although scarce evidence links the use of antiresorptive agents in the context of osteoporosis to the development of MRONJ, these agents are considered a risk factor for this complication. Despite the rare reports of MRONJ in patients with osteoporosis, the severity of symptoms and impact of MRONJ in the patients' quality of life make it imperative for health care professionals to consider this complication when planning invasive dental procedures.

Asunto(s)

Osteonecrosis de los Maxilares Asociada a Difosfonatos , Conservadores de la Densidad Ósea , Medicina Oral , Osteoporosis , Osteonecrosis de los Maxilares Asociada a Difosfonatos/etiología , Osteonecrosis de los Maxilares Asociada a Difosfonatos/prevención & control , Conservadores de la Densidad Ósea/efectos adversos , Brasil , Difosfonatos , Humanos , Osteoporosis/inducido químicamente , Osteoporosis/tratamiento farmacológico , Osteoporosis/prevención & control , Patología Bucal , Calidad de Vida

RESUMEN

BACKGROUND: Metastatic clear cell renal cell carcinoma (CCRCC) should be considered in differential diagnosis of intraoral clear cell tumors, including mucoepidermoid carcinoma (MEC). OBJECTIVE AND STUDY DESIGN: We compared the clinical, histologic, histochemical, and immunohistochemical characteristics of 9 oral metastatic CCRCCs and 8 intraoral clear cell MECs. RESULTS: Oral metastatic CCRCC affected salivary-gland containing tissues in 7 cases (78%). Microscopically, oral metastasis revealed a proliferation of neoplastic clear cells arranged in an alveolar pattern with central blood vessels, features that were not seen in any intraoral clear cell MEC. Mucicarmine staining was positive only in clear cell MEC. Immunohistochemistry showed similarities in cytokeratin expression; vimentin and CD10 were expressed in all oral metastatic CCRCCs but in only 1 clear cell MEC each. CONCLUSIONS: Besides clinical history, the alveolar pattern, vessel distribution, absence of mucicarmine staining, and vimentin and CD10 immunoexpression are useful in histologic differential diagnosis of CCRCC and clear cell MEC.

Asunto(s)

Adenocarcinoma de Células Claras/secundario , Carcinoma Mucoepidermoide/diagnóstico , Carcinoma de Células Renales/secundario , Neoplasias de la Boca/secundario , Adenocarcinoma de Células Claras/irrigación sanguínea , Adenocarcinoma de Células Claras/patología , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma Mucoepidermoide/irrigación sanguínea , Carcinoma Mucoepidermoide/patología , Carcinoma de Células Renales/irrigación sanguínea , Carcinoma de Células Renales/patología , Carmín , Núcleo Celular/ultraestructura , Colorantes , Citoplasma/ultraestructura , Diagnóstico Diferencial , Femenino , Hemorragia/patología , Histocitoquímica , Humanos , Inmunohistoquímica , Queratinas/análisis , Masculino , Microvasos/patología , Persona de Mediana Edad , Neoplasias de la Boca/irrigación sanguínea , Neoplasias de la Boca/diagnóstico , Neoplasias de la Boca/patología , Neprilisina/análisis , Neoplasias de las Glándulas Salivales/irrigación sanguínea , Neoplasias de las Glándulas Salivales/patología , Neoplasias de las Glándulas Salivales/secundario , Vimentina/análisis

RESUMEN

OBJECTIVE: The objective of this investigation was to assess the prevalence of oral lichen planus (OLP) in Brazilian patients infected with hepatitis C virus (HCV) from the state of Rio de Janeiro. STUDY DESIGN: The study group consisted of 134 patients with HCV infection. The control group consisted of 95 individuals. All patients were physically examined for evidence of OLP. The diagnosis of OLP was established on the basis of usual clinical features and histological findings. RESULTS: The prevalence of OLP was 1.5% in patients with HCV infection and 1.1% in the control group. There was no statistically significant difference between the 2 groups (P = .63). CONCLUSION: Our findings indicate that there is no association between OLP and HCV infection in Brazilian patients from the state of Rio de Janeiro.

Asunto(s)

Hepatitis C/complicaciones , Liquen Plano Oral/complicaciones , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Análisis de Varianza , Brasil , Estudios de Casos y Controles , Femenino , Humanos , Modelos Lineales , Masculino , Persona de Mediana Edad

RESUMEN

Oral lichen planus lesions can cause discomfort, pain, and a burning sensation. Therefore, all professionals who deal with the oral cavity must be aware of all the therapeutic options for it. This article presents a review of the literature on oral lichen planus, focusing on its treatment, and also discusses the important and controversial potential for the evolution of oral lichen planus into epidermoid carcinoma.

Asunto(s)

Transformación Celular Neoplásica , Liquen Plano Oral/tratamiento farmacológico , Liquen Plano Oral/patología , Humanos

RESUMEN

This article presents a review of the literature on oral lichen planus, focusing on important aspects of its epidemiology, etiopathogeny, and clinical manifestations. The oral form is an important clinical presentation of lichen planus. It may precede or accompany the skin lesions, or it may be the only manifestation of the disease. Dermatologists, dentists, otorhinolaryngologists, and other specialists who deal with the oral cavity must be aware of this disease so they can diagnose, treat, and keep these patients under observation.

Asunto(s)

Liquen Plano Oral/diagnóstico , Liquen Plano Oral/epidemiología , Biopsia con Aguja , Femenino , Técnica del Anticuerpo Fluorescente , Humanos , Inmunohistoquímica , Incidencia , Liquen Plano Oral/etiología , Liquen Plano Oral/inmunología , Masculino , Pronóstico , Medición de Riesgo , Índice de Severidad de la Enfermedad , Distribución por Sexo

RESUMEN

O objetivo deste trabalho é relatar o caso clínico de uma paciente do sexo feminino, de 13 anos de idade, que apresentava uma lesão de aspecto ulcerado na mucosa do palato duro. Não havia histórico de trauma e a lesão não desapareceu após o uso de antiinflamatório tópico. Foi realizada biópsia excisional, sendo o laudo histopatológico compatível com o fenômeno de extravasamento de muco. Um mês após, a lesão recidivou e nova cirurgia foi realizada com maior margem. O diagnóstico histopatológico foi o mesmo verificado na cirurgia anterior

Asunto(s)

Humanos , Femenino , Adolescente , Mucocele , Hueso Paladar , Mucosa Bucal

RESUMEN

Candida yeasts frequently cause life-threatening systemic infections in immunocompromised hosts. In the present study, gelatin-SDS-PAGE analysis was used to characterize extracellular proteinases in 44 oral clinical isolates of Candida albicans from HIV-positive (29/50) and healthy children (15/50). Our survey indicates that these oral clinical isolates of C. albicans have complex extracellular proteolytic activity profiles, which illustrates the heterogeneity of this species. We showed four distinct proteolytic patterns composed of distinct serine (30-58 kDa) and metalloproteinase (64-95 kDa) activities, based on the inhibition profile with phenylmethylsulfonyl fluoride and 1,10-phenanthroline, respectively. This is the first report on secreted serine and metalloproteinases present in the culture supernatant fluids of C. albicans; however, we did not observe a significant correlation between proteolytic profile expressed by the C. albicans isolates from HIV-positive children and CD4(+) T cell count and plasma viral load.

Asunto(s)

Infecciones Oportunistas Relacionadas con el SIDA/microbiología , Candida albicans/enzimología , Candidiasis Bucal/microbiología , Metaloproteasas/metabolismo , Serina Endopeptidasas/metabolismo , Recuento de Linfocito CD4 , Candida albicans/clasificación , Candida albicans/crecimiento & desarrollo , Candida albicans/aislamiento & purificación , Niño , Preescolar , Medios de Cultivo Condicionados , Infecciones por VIH/complicaciones , Infecciones por VIH/virología , VIH-1/fisiología , Humanos , Lactante , Metaloproteasas/clasificación , Serina Endopeptidasas/clasificación , Carga Viral

RESUMEN

Este trabalho tem como objetivo apresentar uma revisäo da literatura da displasia fibrosa nos maxilares, apresentando os seus principais aspectos clínicos, radiográficos, histopatológicos, assim como as diferentes possibilidades de tratamento e o prognóstico desta condiçäo. Adicionalmente säo relatados dois casos do Departamento de Patologia e Diagnóstico Oral da FO/UFRJ, que estäo sendo acompanhados pelos autores

Asunto(s)

Humanos , Masculino , Femenino , Adulto , Displasia Fibrosa Monostótica/diagnóstico , Displasia Fibrosa Monostótica/etiología , Displasia Fibrosa Monostótica/patología , Displasia Fibrosa Monostótica , Displasia Fibrosa Monostótica/terapia , Maxilar/patología

RESUMEN

A literatura consultada refere-se à displasia ectodérmica hereditária (hipohidrótica e hidrótica) como uma síndrome rara que acomete tecidos derivados do ectoderma apresentando-se estes aplásicos ou hipoplásicos, com vários graus de expressividade. Os portadores apresentam hipohidrose, hipodontia e hipotricose, com "facies" característica, como nos portadores do tipo hidrótica. O presente trabalho visa relatar e discutir três casos de displasia ectodérmica ocorridos em uma mesma família, enfatizando o grau de manifestação e transmissibilidade vertical. Os diversos achados clínicos são mostrados, evidenciando sua importância na Odontologia Holística onde o paciente deve ser visto como um ser bio-psico-social, bem como é dada ênfase à responsabilidade dos Cirurgiões-Dentistas em seu diagnóstico, encaminhamento aos serviços especializados para possível tratamento de reabilitação oral, cariotipia e aconselhamento genético

Asunto(s)

Humanos , Masculino , Femenino , Niño , Adolescente , Adulto , Displasia Ectodérmica/genética , Displasia Ectodérmica/patología , Anomalías Dentarias/patología

RESUMEN

A Displasia Ectodérmica caracteiza-se por ser uma anomalia hereditária, cujas manifestações clínicas compreendem alterações em estruturas de origem ectodérmica, principalmente cabelos, unhas, dentes e pele. Os autores relatam quatro casos com uma baixa expressividade dessa anomalia, em indivíduos de uma mesma família

Asunto(s)

Humanos , Masculino , Femenino , Niño , Adolescente , Displasia Ectodérmica , Anomalías Dentarias

RESUMEN

Os autores tecem considerações a respeito da hemihipertrofia do tipo complexo, juntamente com a descrição de um caso clínico

Asunto(s)

Humanos , Masculino , Adulto , Anomalías Congénitas , Asimetría Facial , Hipertrofia , Síndrome

RESUMEN

Manual de prática cotidiana relativo às principais manifestacões bucais da AIDS e do controle de infeccões na clínica odontológica (FHS)

Asunto(s)

Masculino , Femenino , Humanos , Síndrome de Inmunodeficiencia Adquirida , Contaminación de Equipos , Riesgos Laborales , Salud Bucal , Infecciones Bacterianas , Sangre , Candidiasis Bucal , Desinfección/métodos , Infecciones por VIH , Enfermedades de la Boca , Neoplasias de la Boca , Virosis

RESUMEN

Manual de prática cotidiana relativo às principais manifestaçöes bucais da AIDS e do controle de infecçöes na clínica odontológica (FHS)

Asunto(s)

Humanos , Masculino , Femenino , Contaminación de Equipos/prevención & control , Riesgos Laborales , Salud Bucal , Síndrome de Inmunodeficiencia Adquirida/prevención & control , Infecciones Bacterianas , Sangre , Candidiasis Bucal , Desinfección/métodos , Infecciones por VIH , Enfermedades de la Boca , Neoplasias de la Boca , Virosis

Asunto(s)

Humanos , Masculino , Femenino , Odontología , Enfermedades de la Boca , Síndrome de Inmunodeficiencia Adquirida/prevención & control

RESUMEN

Manual de prática cotidiana relativo às principais manifestacões bucais da AIDS e do controle de infeccões na clínica odontológica (FHS)

Asunto(s)

Humanos , Masculino , Femenino , Salud Bucal , Síndrome de Inmunodeficiencia Adquirida , Riesgos Laborales , Contaminación de Equipos , Enfermedades de la Boca , Infecciones Bacterianas , Infecciones por VIH , Virosis , Sangre , Neoplasias de la Boca , Candidiasis Bucal , Desinfección/métodos

Asunto(s)

Humanos , Masculino , Femenino , Síndrome de Inmunodeficiencia Adquirida , Infecciones por VIH , Manifestaciones Bucales , Infecciones Bacterianas , Candidiasis Bucal , Control de Enfermedades Transmisibles , Gingivitis , Herpes Zóster , Control de Infección Dental , Leucoplasia Vellosa , Papiloma , Periodontitis , Estomatitis Herpética