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Objetivo: El objetivo principal de este estudio es evaluar la concordancia del reporte de la clasificación Vesical Imaging-Reporting and Data System (VI-RADS®) en resonancia magnética (RM) y el reporte de patología del espécimen de cistectomía y definir si este estudio puede considerarse un estándar en el proceso de estadificación en el paciente con diagnóstico clínico de cáncer de vejiga. Método: Estudio analítico retrospectivo de corte transversal, se incluyeron 34 pacientes llevados a cistectomía radical o parcial a quienes se realizó RM multiparamétrica prequirúrgica y se realizó un estudio de concordancia entre la clasificación VI-RADS® y el resultado de patología. Todas las resonancias fueron leídas y revisadas por un único radiólogo institucional. Resultados: El estudio de concordancia como resultado principal mostró un área bajo la curva para VI-RADS® ≥ 4 y resultado patológico positivo para compromiso muscular de 0,84, con una sensibilidad del 89.3% y especificidad del 50%, demostrando la adecuada precisión diagnóstica de la prueba. Conclusiones: La clasificación VI-RADS® es una herramienta de diagnóstico caracterizada por un excelente rendimiento diagnóstico cuando se evalúa la concordancia con el reporte de la patología final en el espécimen de la cistectomía.
Objective: The main objective of this study is to assess the concordance of the magnetic resonance imaging (MRI) Vesical Imaging-Reporting and Data System (VI-RADS®) classification report and the pathology report of the cystectomy specimen and to define whether this study can be considered a standard in the staging process in patients with a diagnosis of bladder cancer. Method: Retrospective, cross-sectional analytical study that included 34 patients undergoing radical or partial cystectomy who underwent pre-surgical multiparametric MRI. A concordance study was performed between the VI-RADS® classification and the pathology result. All MRIs were read and reviewed by a single institutional radiologist. Results: The concordance study as the main result showed an area under the curve for VI-RADS® ≥ 4 and a positive pathological result for muscle involvement of 0.84, with a sensitivity of 89.3% and a specificity of 50%, demonstrating the adequate diagnostic accuracy of the test. Conclusions: The VI-RADS® classification is a diagnostic tool characterized by excellent diagnostic performance when evaluating the agreement with the final pathology report in the cystectomy specimen.
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Humanos , Persona de Mediana Edad , AncianoRESUMEN
BACKGROUND: Growing evidence suggests that pesticide exposure may influence respiratory health, but data in young children are very limited. We examined the association of prenatal pesticide exposure with lower respiratory tract infections (LRTIs) and wheeze at one year of age in children from the Infants' Environmental Health (ISA) study in Costa Rica. METHODS: We measured seven pesticide metabolites, including ethylenethiourea (ETU, metabolite of mancozeb), in maternal urine samples collected repeatedly during pregnancy. For each woman, we averaged pesticide concentrations during each half of pregnancy (≤20 and >20 weeks of gestation) and across repeated samples collected over the course of pregnancy. We collected information about LRTIs (n = 355) and wheezing (n = 272) during the first year of life from mothers when their children were 11-19 months old. We fit multivariable logistic regression models using high (quartile 4) vs. low (quartiles 1-3) urinary pesticide concentrations as exposures and adjusted models for maternal age, education, parity, gestational age at birth, and child sex. RESULTS: Ten percent of the children had at least one LRTI and 39% had at least one episode of wheezing during their first year of life. Median (25-75th percentile) specific gravity-corrected urinary ETU concentrations during the first half, second half, and over the course of pregnancy were 3.4 (2.1-5.0), 3.3 (2.2-4.7), and 3.4 (2.4-5.0) ng/mL, respectively. We observed that high urinary ETU concentrations during the first half of pregnancy were associated with increased odds of LRTI (OR = 2.45; 95% CI: 0.96, 6.26), whereas high urinary ETU concentrations during the second half of pregnancy were associated with decreased odds of wheezing (OR = 0.50; 95% CI: 0.26, 0.96). We found that the association between high urinary ETU concentrations during the first half of pregnancy and LRTIs persisted among mother-child pairs with either high or low ETU concentrations during the second half. In contrast, the association of high urinary ETU concentrations during the second half of pregnancy with wheezing was attenuated when we simultaneously adjusted for urinary ETU concentrations during the first half. We observed null associations between other pesticide metabolites measured during pregnancy and respiratory outcomes. CONCLUSIONS: Our data indicate that exposure to mancozeb/ETU during the first half of pregnancy may be associated with respiratory outcomes in the first year of life.
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Contaminantes Ambientales/orina , Plaguicidas/orina , Efectos Tardíos de la Exposición Prenatal , Ruidos Respiratorios , Infecciones del Sistema Respiratorio/epidemiología , Adulto , Etilenotiourea/metabolismo , Femenino , Humanos , Lactante , Salud del Lactante , Masculino , Maneb/orina , Exposición Materna , Intercambio Materno-Fetal , Embarazo , Adulto Joven , Zineb/orinaRESUMEN
Various countries throughout the world have started their efforts in designing and implementing smart cities. China alone has over 300 smart city projects, with strong participation by industries and government offices. India too have allocated trillions in budget to build over 100 smart cities. An essential part of a smart city is transport. In this paper, we will discuss the current state, developments, and some of the emerging advances in transportation technologies and how these advances in smart roads will prepare the society towards the realization of future smart cities.
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Mujer de 43 años que consultó a guardia por dolor en el compartimiento central del cuello, región retroesternal y disfagia de 48 hs. de evolución, asociado a fiebre y escalofríos. Refirió ingesta de carne molida (hamburguesa) antes del comienzo de los síntomas. En el examen físico se constato temperatura de 38 °C, eritema en región paratraqueal izquierda con dolor a la palpación y enfisema subcutáneo y en el laboratorio tenía un recuento de glóbulos blancos de 13.000/mm3. En las imágenes de cuello y tórax se confirmo la presencia de enfisema subcutáneo en región cervical izquierda, cuerpo extraño en esófago cervical y rarefacción de la grasa paratraqueal izquierda (Fig. 1 a y b, flechas). Se realizó esofagoscopia rígida para remoción del cuerpo extraño (vidrio), drenaje de absceso cervical y mediastino superior, esofagostoma cervical y gastrostomía de alimentación (Fig. 2 a y b, flechas). El hallazgo fue una perforación en el borde izquierdo de 2 cm de diámetro y otra de 5 mm en cara posterior del esófago cervical con absceso paraesofágico. La paciente evoluciono favorablemente, cumplió 7 días de tratamiento antibiótico y se otorgo alta institucional con control ambulatorio