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The grey mouse lemur: a non-human primate model for ageing studies.

Languille, S; Blanc, S; Blin, O; Canale, C I; Dal-Pan, A; Devau, G; Dhenain, M; Dorieux, O; Epelbaum, J; Gomez, D; Hardy, I; Henry, P-Y; Irving, E A; Marchal, J; Mestre-Francés, N; Perret, M; Picq, J-L; Pifferi, F; Rahman, A; Schenker, E; Terrien, J; Théry, M; Verdier, J-M; Aujard, F.

Ageing Res Rev ; 11(1): 150-62, 2012 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-21802530

RESUMEN

The use of non-human primate models is required to understand the ageing process and evaluate new therapies against age-associated pathologies. The present article summarizes all the contributions of the grey mouse lemur Microcebus murinus, a small nocturnal prosimian primate, to the understanding of the mechanisms of ageing. Results from studies of both healthy and pathological ageing research on the grey mouse lemur demonstrated that this animal is a unique model to study age-dependent changes in endocrine systems, biological rhythms, thermoregulation, sensorial, cerebral and cognitive functions.

Asunto(s)

Envejecimiento/patología , Envejecimiento/fisiología , Cheirogaleidae/fisiología , Modelos Animales , Animales , Humanos , Especificidad de la Especie , Investigación Biomédica Traslacional/métodos , Investigación Biomédica Traslacional/tendencias

RESUMEN

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