RESUMEN
Investigating the growing concern of pediatric burn injuries caused by social media challenges. Adolescents, seeking fame or succumbing to peer pressure, engage in risky behaviors, recording and sharing them online. The study presents two case reports detailing severe burn injuries resulting from such challenges, highlighting the physical and psychological toll on affected children and their families. In Case report 1, a 14-year-old suffered severe burns attempting a TikTok challenge involving igniting a soaked t-shirt. The patient's critical condition necessitated intensive care, surgical procedures, and skin grafts, accompanied by complications like anemia and sepsis. Case report 2 features a 9-year-old who sustained extensive burns while attempting another social media challenge. Treatment included escharolysis, skin grafts, and surgeries, with complications managed during the recovery process. A literature review explores social media-generated burn injuries, revealing their physical and psychological impact. The influence of social proof and peer pressure on adolescents' behavior in the digital age is discussed. The pandemic's effect on mental health is considered, emphasizing the vulnerability of adolescents to such challenges. In conclusion, the paper highlights the rising incidence of teen burn injuries linked to social media challenges. Urgent measures are needed to restrict the promotion of risky behaviors on social platforms. Alongside state-of-the-art burn treatments, comprehensive psychological care is essential for young patients and their families to cope with trauma. Increased content monitoring and the dissemination of prevention materials are recommended to mitigate the occurrence of such incidents.
Asunto(s)
Quemaduras , Medios de Comunicación Sociales , Humanos , Adolescente , Niño , Masculino , Femenino , COVID-19/epidemiologíaRESUMEN
Metadynamics is a powerful computational tool to obtain the free-energy landscape of complex systems. The Monte Carlo algorithm has proven useful to calculate thermodynamic quantities associated with simplified models of proteins, and thus to gain an ever-increasing understanding on the general principles underlying the mechanism of protein folding. We show that it is possible to couple metadynamics and Monte Carlo algorithms to obtain the free energy of model proteins in a way which is computationally very economical.
Asunto(s)
Algoritmos , Modelos Moleculares , Método de Montecarlo , Proteínas/química , Proteínas/genética , Propiedades de Superficie , TermodinámicaRESUMEN
In performing protein-denaturation experiments, it is common to employ different kinds of denaturants interchangeably. We make use of molecular dynamics simulations of Protein L in water, in urea, and in guanidinium chloride (GdmCl) to ascertain if there are any structural differences in the associated unfolding processes. The simulation of proteins in solutions of GdmCl is complicated by the large number of charges involved, making it difficult to set up a realistic force field. Furthermore, at high concentrations of this denaturant, the motion of the solvent slows considerably. The simulations show that the unfolding mechanism depends on the denaturing agent: in urea the beta-sheet is destabilized first, whereas in GdmCl, it is the alpha-helix. Moreover, whereas urea interacts with the protein accumulating in the first solvation shell, GdmCl displays a longer-range electrostatic effect that does not perturb the structure of the solvent close to the protein.
Asunto(s)
Proteínas Bacterianas/química , Proteínas Bacterianas/ultraestructura , Guanidina/química , Modelos Químicos , Modelos Moleculares , Urea/química , Sitios de Unión , Simulación por Computador , Unión Proteica , Conformación Proteica , Desnaturalización ProteicaRESUMEN
We present a generalization of the self-consistent analysis of carbon nanotube (CNT) field effect transistors (FETs) to the case of multi-wall/multi-band coherent carrier transport. The contribution to charge diffusion, due to different walls and sub-bands of a multi-wall (mw) CNT is shown to be non-negligible, especially for high applied external voltages and 'large' diameters. The transmission line formalism is used in order to solve the Schrödinger equation for carrier propagation, coupled to the Poisson equation describing the spatial voltage distribution throughout the device. We provide detailed numerical results for semiconducting mw-nanotubes of different diameters and lengths, such as current-voltage characteristics and frequency responses.