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Int J Biol Macromol ; 136: 1112-1118, 2019 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-31233797

RESUMEN

Both gelatin and pectin have the ability to trap salt and facilitate its release under simulated gastric conditions. The objective of this study was to develop a pectin-gelatin gel fortified with oral rehydration solution/s (ORS) that can maintain a more rigid structure to limit salt mobility (potentially less salty taste), yet allow rapid release in simulated gastric conditions. Two gels containing both pectin and gelatin were developed: (1) low salt (LS) containing 2.6 g/L salt and 13.5 g/L sugar and (2) high salt (HS) containing 5.2 g/L salt and 27.0 g/L sugar. The ORS-fortified gels were compared with commercially available gelatin gels and a control pectin-gelatin gel without added salt or sugar. A stronger gel network (higher G') and higher viscosity was noted for HS compared to other samples. HS had slower salt release (80.70 ±â€¯1.92%) than LS (95.95 ±â€¯3.82%) at 1 min in simulated gastric conditions. After 120 min, HS showed up to 99.38 ±â€¯1.08% release of salt, while LS had 95.95 ±â€¯3.82% release. HS had a favorable textural profile, having values more similar to the ready-to-eat commercial cup gel than did the LS formulation. The HS formulation resulted in a stable structure for ORS delivery and beneficial release properties.


Asunto(s)
Biomimética , Liberación de Fármacos , Mucosa Gástrica/metabolismo , Gelatina/química , Pectinas/química , Soluciones para Rehidratación/química , Cloruro de Sodio/química , Color , Portadores de Fármacos/química , Geles , Concentración de Iones de Hidrógeno , Soluciones para Rehidratación/metabolismo , Reología , Agua/química
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