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Little is known about the influence of (impaired) neurodevelopment on cognitive aging. We here used a mouse model for tuberous sclerosis (TS) carrying a heterozygous deletion of the Tsc2 gene. Loss of Tsc2 function leads to mTOR hyperactivity in mice and patients. In a longitudinal behavioral analysis, we found premature decline of hippocampus-based cognitive functions together with a significant reduction of immediate early gene (IEG) expression. While we did not detect any morphological changes of hippocampal projections and synaptic contacts, molecular markers of neurodegeneration were increased and the mTOR signaling cascade was downregulated in hippocampal synaptosomes. Injection of IGF2, a molecule that induces mTOR signaling, could fully rescue cognitive impairment and IEG expression in aging Tsc2+/- animals. This data suggests that TS is an exhausting disease that causes erosion of the mTOR pathway over time and IGF2 is a promising avenue for treating age-related degeneration in mTORopathies.

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Objetivo: Evaluar los conocimientos generales y preferencias iniciales de las pacientes en edad fértil en España sobre el manejo de la presentación podálica a término. Material y métodos: Se trata de un estudio transversal basado en la administración a las participantes de un cuestionario para evaluar sus conocimientos sobre la versión cefálica externa y preferencias entre esta, la cesárea y el parto de nalgas. Resultados: Doscientas mujeres participaron en el estudio. Cuarenta y uno (20,5%) habían oído hablar de la versión cefálica externa. El 29,27% por un ginecólogo, el 12,20% por una matrona, el 39,02% por conocidos, el 26,83% por internet o redes sociales y el 2,44% por la televisión. La edad, la formación académica y el hecho de estar embarazadas no fueron factores influyentes para conocer o no la versión cefálica externa. Las multíparas conocían mejor el procedimiento (OR = 2,1; IC 95%: 1,14-3,88). El 63,5% elegirían la versión cefálica externa frente al 35% que eligieron la cesárea programada. El 1,5% se decantaron por un parto de nalgas. La mayoría de las mujeres consideraron la técnica efectiva (58%) y segura tanto para la madre (55%) como para el feto (46,5%). Conclusiones: El conocimiento de las pacientes sobre la versión cefálica externa y las fuentes de las que dicen tener la información demuestran una carencia en la información que reciben por parte de ginecólogos y matronas.(AU)

Objective: To assess the knowledge and preferences for term breech management in women of childbearing age. Material and methods: Cross-sectional study based on a survey for women to evaluate heir knowledge of external cephalic version and their preferences between this procedure, vaginal breech delivery or cesarean section. Results: 200 women participated. 41 women (20.5%) had heard of external cephalic version; 29.27% from gynecologists, 12.20% from midwives, 39.02% from acquaintances, 26.83% from the internet or social networks and 2.44% from television. Multiparous woman knew more about the procedure (OR = 2.1; 95% CI:1.14-3.88). 63.5% would choose external cephalic version. 35% would prefer programmed cesarean section. 1.5% would opt for a breech delivery. Most of the women considered the technique to be effective (58%) and safe for both the mother (55%) and the fetus (46.5%). Conclusions: Patients’ knowledge of external cephalic version is poor. The results show a lack of information by their healthcare providers.(AU)

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The sensing behavior to liquids for Acoustic Plate Modes (APMs) propagating along 64°Y, 90°X LiNbO3 plate was investigated vs. two electric boundary conditions. The changes in the APMs phase velocity and attenuation were measured upon exposure to different liquids wetting one of the surfaces of the plate, either free or electrically shorted by a thin conductive Al layer. The experimental data confirm that the presence of a metallic layer covering one of the plate surfaces affects the viscosity and temperature sensitivity of the device. The differences between the sensor response for various liquids, with free or metalized faces, are interpreted in terms of the APM polarization.

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Patients with transient ischemic attacks (TIA) were previously shown to have high plasma values of thiobarbituric acid-reactive substances (TBA-RS). To study whether these changes could be related to platelet activability, TBA-RS was investigated in 24 TIA patients before and 24 h after 1 g aspirin, an inhibitor of platelet cyclooxygenase pathway. Baseline TBA-RS values were significantly higher in TIA than in controls. Conversely, TIA patients had TBA-RS values after aspirin similar to controls, suggesting that the increase of plasma TBA-RS was not attributable to platelet hyperfunction. The evaluation of metabolic profile showed that patients with highest TBA-RS had hypercholesterolemia, hypertriglyceridemia, and/or diabetes mellitus. This study suggests that the increase of plasma TBA-RS in TIA could be an epiphenomenon of altered metabolic pathway.

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Blood lipid profile was investigated in 40 patients suffering from peripheral vascular disease (PVD). The most frequent abnormality was the increase of cholesterol and triglycerides. HDL-cholesterol and the subfractions HDL2 and HDL3 were decreased but not significantly. Cholesterol/HDL-cholesterol ratio was significantly increased suggesting an abnormal cholesterol distribution on lipoprotein fractions. Apolipoproteins AI and AII were within normal range while apolipoproteins B, CII, CIII, and E were significantly increased. This study provide further findings on the blood lipid abnormalities in patients affected by PVD.

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