RESUMEN
Water gushing is a common engineering geological disaster in the process of foundation pit construction. Its successful judgment directly affects the safety of engineering construction. Taking the case of water gushing at the bottom of the foundation pitas as a research object, the mechanism and treatment of water gushing in foundation pits, the stability against water gushing, and its influencing factors are analyzed with a field investigation, field testing, and theoretical calculation. The calculation formula for the safety factor and critical thickness of the foundation pit against surges, considering the influence of multiple factors, is deduced. The influence of the height of the confined water level, the thickness of the water-resisting layer, the shear strength of the soil mass, the reinforcement depth of the soil mass in the pit, and the diameter of the bearing pile in the pit on the safety factor of the foundation pit surge are expounded. In addition, measures such as the reinforcement of the soil mass in the passive area in the pit, the increase in the thickness of the water-resisting layer, and the reduction in the confined water level are proposed to improve the anti-surge stability of the foundation pit. A new monitoring method is proposed for characterizing uplift deformation at the bottom of the pit without affecting normal construction. The research results show that: (1) the minimum safety factor against surges, considering multiple factors, is 1.455, and the critical thickness is 5.87 m, which is in line with specifications. (2) Measures such as reinforcing the soil in the passive zone of the pit, increasing the thickness of the water-insulating layer, and lowering the bearing pressure level are used to improve the stability of the pit against surges. (3) The pit, obtained by the pit bottom counter-pressure, pumping water out of the pit, and the timely construction of the pit bottom bedding to block the program, exhibits a measured maximum bottom plate pressure of 115.189 kPa, and the deformation corresponding to the method proposed in this paper is 1.406 mm, which is better disposed in the field. The research results provide a reference basis for the judgment of anti-surge stability of foundation pits and similar engineering applications.
RESUMEN
BACKGROUND: Changes in pharmacological agents and advancements in laboratory assays have changed the gonadotropin-releasing hormone analog stimulation test. OBJECTIVE: To determine the best predictive model for detecting puberty in girls. SUBJECTS: Thirty-five girls, aged 2 years 7 months to 9 years 3 months, with central precocious puberty (CPP) (n=20) or premature thelarche/premature adrenarche (n=15). METHODS: Diagnoses were based on clinical information, baseline hormones, bone age, and pelvic sonogram. Gonadotropins and E2 were analyzed using immunochemiluminometric assay. Logistic regression for CPP was performed. RESULTS: The best predictor of CPP is the E2-change model based on 3- to 24-h values, providing 80% sensitivity and 87% specificity. Three-hour luteinizing hormone (LH) provided 75% sensitivity and 87% specificity. Basal LH lowered sensitivity to 65% and specificity to 53%. CONCLUSIONS: The E2-change model provided the best predictive power; however, 3-h LH was more practical and convenient when evaluating puberty in girls.
Asunto(s)
Técnicas de Diagnóstico Endocrino , Gonadotropinas/sangre , Pubertad Precoz/sangre , Pubertad , Niño , Preescolar , Técnicas de Diagnóstico Endocrino/normas , Femenino , Humanos , Pubertad Precoz/diagnóstico , Valores de Referencia , Estudios Retrospectivos , Estimulación QuímicaRESUMEN
OBJECTIVE: To highlight complexities in defining vitamin D sufficiency in children. STUDY DESIGN: Serum 25-(OH) vitamin D [25(OH)D] levels from 140 healthy obese children age 6 to 21 years living in the inner city were compared with multiple health outcome measures, including bone biomarkers and cardiovascular risk factors. Several statistical analytic approaches were used, including Pearson correlation, analysis of covariance (ANCOVA), and "hockey stick" regression modeling. RESULTS: Potential threshold levels for vitamin D sufficiency varied by outcome variable and analytic approach. Only systolic blood pressure (SBP) was significantly correlated with 25(OH)D (r = -0.261; P = .038). ANCOVA revealed that SBP and triglyceride levels were statistically significant in the test groups [25(OH)D <10, <15 and <20 ng/mL] compared with the reference group [25(OH)D >25 ng/mL]. ANCOVA also showed that only children with severe vitamin D deficiency [25(OH)D <10 ng/mL] had significantly higher parathyroid hormone levels (Δ = 15; P = .0334). Hockey stick model regression analyses found evidence of a threshold level in SBP, with a 25(OH)D breakpoint of 27 ng/mL, along with a 25(OH)D breakpoint of 18 ng/mL for triglycerides, but no relationship between 25(OH)D and parathyroid hormone. CONCLUSIONS: Defining vitamin D sufficiency should take into account different vitamin D-related health outcome measures and analytic methodologies.