RESUMEN

In this study, some 1-methylene-2,3-diaryl-1,2-dihydropyrazino[1,2-a]benzimidazole and some 1-(2-arylvinyl)-3-arylpyrazino[1,2-a]benzimidazole derivatives were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR and MASS spectroscopic data and elemental analyses results. Anticancer and anti-HIV activities of the compounds were examined, however no anti-HIV activity was seen; highly notable anticancer activity was obtained. It was also observed that the compounds were more potent against leukaemia cell lines.

Asunto(s)

Fármacos Anti-VIH/síntesis química , Fármacos Anti-VIH/farmacología , Antineoplásicos/síntesis química , Antineoplásicos/farmacología , Bencimidazoles/síntesis química , Bencimidazoles/farmacología , Antineoplásicos/uso terapéutico , Bencimidazoles/uso terapéutico , División Celular/efectos de los fármacos , Línea Celular , Evaluación Preclínica de Medicamentos , VIH/efectos de los fármacos , Humanos , Estructura Molecular , Neoplasias/tratamiento farmacológico , Neoplasias/patología , Relación Estructura-Actividad , Células Tumorales Cultivadas