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Sangre (Barc) ; 40(1): 67-9, 1995 Feb.
Artículo en Español | MEDLINE | ID: mdl-7536352

RESUMEN

A total number of 1,149 specimens of cord-blood were subjected to cellulose acetate gel electrophoresis in order to estimate the incidence of haemoglobinopathies in newborn infants (NBI). It was found that 4.37% of black NBI and 0.54% of white NBI were AS carriers. Those samples with HbS or HbC were verified by means of agar-citrate electrophoresis at pH 6.2. Haemoglobin Bart was commonest in black (3.1%) than in white (0.4%) NBI. A slow haemoglobin variant was found with an alpha-chain mutation. The concentration of gamma G was estimated by separation of gamma G and gamma A chains with polyacrylamide gel electrophoresis, and it ranged between 52% and 94%, which could be attributed to the fact that the shift from HbF to HbA is not simultaneous in all the red-cell population.


Asunto(s)
Electroforesis en Gel de Poliacrilamida , Sangre Fetal/química , Hemoglobina Fetal/análisis , Globinas/análisis , Población Negra , Hemoglobina Fetal/química , Humanos , Recién Nacido , Población Blanca
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