RESUMEN

It was shown that in vitro irradiation (8 Gy) of murine peritoneal macrophages suppressed their spontaneous cytotoxity and induced growth-stimulating activity. Exposure to 4 Gy induced mRNA proximal factors--TGF-beta and TNF-alpha and boosted growth-stimulating activity. These effects should be considered when evaluating efficacy of radiotherapy for tumors.

Asunto(s)

Macrófagos Peritoneales/metabolismo , Macrófagos Peritoneales/efectos de la radiación , Animales , Ratones , Ratones Endogámicos BALB C , ARN Mensajero/efectos de la radiación , Dosis de Radiación , Radiación Ionizante , Factor de Crecimiento Transformador beta/efectos de la radiación , Factor de Necrosis Tumoral alfa/efectos de la radiación