RESUMEN
A kinetic study of the effect of thermoheliox (inhalation of a helium and oxygen mixture, 70 °C) on the functional hemodynamics of the human brain by functional magnetic resonance imaging was carried out. The dynamic responses of the BOLD signal were found to be biphasic. An empirical equation describing the first phase of the hemodynamic response to visual stimulus was proposed. It was shown that preliminary inhalation of thermoheliox stimulates the hemodynamic responses by slowing down the vasoconstriction.
RESUMEN
The high efficiency of using thermoheliox (inhalation with a high-temperature mixture of helium and oxygen) in the treatment of patients affected by COVID-19 was shown. The dynamics of accumulation of IgG, IgM, and C-reactive protein (CRP) in patients with coronavirus infection in the "working" and control groups was studied experimentally. It was shown that thermoheliox intensifies the synthesis of IgG, IgM, and CRP antibodies, while eliminating the induction period on the kinetic curves of the synthesis of specific antibodies in the IgG form and transfers the synthesis of CRP to a fast phase. The results of experiments confirm the previously obtained data based on the analysis of the kinetic model of the development of coronaviral infection in the human body.
Asunto(s)
Anticuerpos Antivirales/inmunología , Proteína C-Reactiva/biosíntesis , COVID-19/metabolismo , COVID-19/prevención & control , Inmunidad/inmunología , Vacunación/métodos , COVID-19/inmunología , Humanos , Cinética , Glicoproteína de la Espiga del Coronavirus/inmunologíaRESUMEN
A kinetic model is proposed to describe the key features of development of an acute viral infection, accumulation of antibodies, and immune response in the human body. The general features of immune system stimulation by thermoheliox are described. The model can be used for developing the basis for the application of thermoheliox in the treatment of patients affected by coronavirus.
RESUMEN
A kinetic model of the development of acute viral infection is proposed and the dynamic behavior of key variables, including the concentrations of viral particles, infected cells, and pathogenic microorganisms, is described. The change in the hydrogen ion concentration in the lungs and pH dependence of the activity of carbonic anhydrase, a key respiration enzyme, are critical factors. An acute bifurcation transition determining either the life or collapse of the system is demonstrated. The transition is associated with exponential increase in the concentrations of participants in the process and with functioning of the key enzyme, carbonic anhydrase. A physicochemical interpretation is given for the therapeutic effect of temperature rise and potential therapeutic effect of "thermoheliox", that is, breathing by heated helium-oxygen mixture.
RESUMEN
In the framework of the kinetic model, the functioning of the cholinergic synapse is considered. The results of mathematical modeling of changes in the level of acetylcholine, induced pH impulse, the influence of the frequency of impulse transmission and inhibition of acetylcholinesterase are presented. Physicochemical explanation for a number of important physiological phenomena, such as neuromuscular paralysis, the molecular mechanism of neurological memory, and actions of nerve poisons and toxins, is given.
Asunto(s)
Acetilcolina/química , Acetilcolinesterasa/metabolismo , Encéfalo/fisiología , Colinérgicos/química , Unión Neuromuscular/metabolismo , Sinapsis/fisiología , Acetilcolina/metabolismo , Colinérgicos/metabolismo , Humanos , Cinética , Modelos Teóricos , Toxinas Biológicas/metabolismoRESUMEN
A kinetic model describing the dynamics of synaptic "discharge" taking into account the kinetics of the injection of the neurotransmitter into the synaptic cleft, the pH-dependence of the catalytic activity of the enzyme, and diffusion withdrawal of protons is proposed. The model provides a physicochemical explanation for a number of important physiological phenomena, such as the neuromuscular paralysis, the molecular mechanism of neurological memory, and the effect of some neurotoxins and drugs.
Asunto(s)
Encéfalo/metabolismo , Inhibidores de la Colinesterasa/farmacología , Receptores Colinérgicos/metabolismo , Sinapsis/metabolismo , Ácido Acético/química , Acetilcolina/metabolismo , Acetilcolinesterasa/metabolismo , Encéfalo/efectos de los fármacos , Colina/química , Colinérgicos/farmacología , Humanos , Concentración de Iones de Hidrógeno , Cinética , Unión Neuromuscular , Neuronas/metabolismo , Neurotoxinas/metabolismo , Neurotransmisores/farmacología , Plaguicidas , Protones , Receptores Colinérgicos/efectos de los fármacos , Sinapsis/efectos de los fármacosRESUMEN
A mathematical model of the DNA elongation stage is proposed, and a formula for calculating the characteristic time of doubling a DNA strand consisting of a large numbers of nucleotides was derived. It is shown that, when the number of nucleotides is greater than 50, it is fair to use a linear dependence of the elongation time on the number of nucleotides. Calculations of the DNA elongation time for a number of organisms are given.
Asunto(s)
ADN/genética , Modelos Biológicos , ADN/biosíntesis , CinéticaAsunto(s)
Carcinoma de Células Renales/cirugía , Puente de Arteria Coronaria/métodos , Estenosis Coronaria/cirugía , Neoplasias Renales/cirugía , Nefrectomía/métodos , Carcinoma de Células Renales/complicaciones , Estenosis Coronaria/complicaciones , Estudios de Seguimiento , Humanos , Neoplasias Renales/complicaciones , Masculino , Persona de Mediana EdadRESUMEN
Variation in sex pheromone composition was studied in large fruit-tree tortrix. The pheromone contained cis-11-tetradecenyl acetate and trans-11-tetradecenyl acetate as macrocomponents as well as microcomponents cis-11-tetradecenol and trans-11-tetradecenol with the prevalence of cis-11-tetradecenyl acetate and cis-11-tetradecenol. The pheromone composition depended in part on the genotype of the male parent. Inbreeding increased the proportion of trans-11-tetradecenyl acetate and trans-11-tetradecenol.