RESUMEN
Upon stimulation and blockade of dopaminergic system of rats in the shuttle box the correlation between the strategy of escape behavior and functional state of dopaminergic system has been found. The modulatory effect of these systems on the mechanism of the adequate choice is suggested.
Asunto(s)
Conducta de Elección/efectos de los fármacos , Receptores Dopaminérgicos/efectos de los fármacos , Animales , Benserazida/farmacología , Encéfalo/efectos de los fármacos , Encéfalo/fisiología , Conducta de Elección/fisiología , Combinación de Medicamentos , Haloperidol/farmacología , Levodopa/farmacología , Masculino , Estimulación Física/métodos , Ratas , Tiempo de Reacción/efectos de los fármacos , Tiempo de Reacción/fisiología , Receptores Dopaminérgicos/fisiología , Estrés Psicológico/fisiopatologíaRESUMEN
The paper shows the dependence of behavioral changes provoked by corazol on individual characteristics of the animals. The rats with high activity in the ATS demonstrated the highest response to the drugs.
Asunto(s)
Reacción de Fuga/efectos de los fármacos , Pentilenotetrazol/farmacología , Animales , Condicionamiento Clásico/efectos de los fármacos , Individualidad , Masculino , Estimulación Física , Ratas , Ratas WistarRESUMEN
The free behaviour experiments on rats showed during the first day the tuftsin-induced (0.3 mg/kg i. p.) increment of epileptic discharge in all the structures simultaneously. Open field behaviour depended on the sequence of penicillin and tuftsin injections. The rats with tuftsin used after the epileptiformic activity has been developed showed the behaviour analogical to the penicillin-injected animals. The preventive injections of tuftsin resulted in restoration of all behavioural indications by the third day. The optimal corrective effect has been obtained with tuftsin used preventively.
Asunto(s)
Epilepsia/inducido químicamente , Penicilinas , Tuftsina/farmacología , Animales , Encéfalo/efectos de los fármacos , Electroencefalografía , Epilepsia/fisiopatología , RatasRESUMEN
A study was made of the influence of ablation of the entorhinal cortex on conditioned reflexes to present and trace stimuli. Ablation resulted in a long-lasting and considerable disturbance of differentiation of time macrointervals. After the operation, elaboration or restoration of the conditioned reflex to time was delayed five or six times as compared with intact animals. There was no change in the state of motor alimentary conditioned reflex to different (single or complex) present stimuli regardless of whether the ablation was performed after or before the elaboration of conditioned reflexes. Similar results were obtained in animals of different phylogenetic groups (rats and dogs).