RESUMEN
Twenty pediatric patients, age range 7-13 years, affected by asthma, have been treated with a sustained release preparation of theophylline once daily (mean dosage 13 mg/kg). The findings of plasma levels of theophylline below therapeutic range twenty four hours after dosing, in steady-state conditions, underline the need of individualized therapy specially in pediatric patients. The Authors observed a good therapeutic effect of this sustained release preparation, as expressed by improvement of symptomatology and pulmonary function tests, together with the sparing effect on other drugs. No side effects have been observed.
Asunto(s)
Asma/tratamiento farmacológico , Teofilina/uso terapéutico , Adolescente , Asma/sangre , Asma/fisiopatología , Niño , Enfermedad Crónica , Preparaciones de Acción Retardada , Evaluación de Medicamentos , Femenino , Volumen Espiratorio Forzado , Humanos , Masculino , Teofilina/sangreAsunto(s)
Cromolin Sódico/uso terapéutico , Hipersensibilidad a los Alimentos/tratamiento farmacológico , Niño , Preescolar , Femenino , Hipersensibilidad a los Alimentos/diagnóstico , Hipersensibilidad a los Alimentos/inmunología , Humanos , Inmunoglobulina E/análisis , Lactante , Pruebas Intradérmicas , Masculino , RadioinmunoensayoRESUMEN
We tested a new product containing aminophylline with 1,56% alcohol as therapy of bronchospasm in childhood to evaluate therapeutic activity, tolerance and adverse reactions. Authors confirm the usefulness of this product in childhood but dosage must be individualized with monitoring of theophylline blood levels.
Asunto(s)
Aminofilina/uso terapéutico , Espasmo Bronquial/tratamiento farmacológico , Aminofilina/sangre , Espasmo Bronquial/sangre , Niño , Preescolar , Femenino , Humanos , Lactante , MasculinoRESUMEN
In 30 children with homozygous beta-thalassemia the hemostasis screening tests (bleeding time, PT, PTT), platelet count and specific assays of clotting factors were carried out 25 days after their last transfusion. PT, PTT, and bleeding time showed minor variations; considerable thrombocytosis was found in splenectomized patients. Factors IX and XII were decreased in a high proportion of patients, the vitamin K-dependent factors (II, VII, IX, X) were slightly reduced and factors I, V and VIII remained within the normal range in a majority of patients. Hepatic failure resulting in defective protein synthesis does not explain the more marked impairment of factors XI and XII, which might be secondary to activation of the intrinsic coagulation and/or kallikrein systems following intravascular haemolysis and multiple blood transfusions.