RESUMEN

INTRODUCTION: The use of less than the traditional 72-hour course of oral N-acetylcysteine has been an alternative treatment option following potentially toxic acute and chronic acetaminophen ingestions felt to be at low risk of developing hepatotoxicity. While clinical experience with shortened treatment duration is extensive, there are few studies evaluating the effectiveness and extent to which these regimens may be used. METHODS: A large statewide poison center database was reviewed for all acetaminophen exposures involving potentially toxic acute and chronic ingestions, in addition to those taking place at unknown times. Patients were identified who met laboratory criteria for early N-acetylcysteine (NAC) discontinuation (APAP>10 micro/mL, INR

Asunto(s)

Acetaminofén/envenenamiento , Acetilcisteína/administración & dosificación , Analgésicos no Narcóticos/envenenamiento , Antídotos/administración & dosificación , Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control , Administración Oral , Adolescente , Adulto , Anciano , California , Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Esquema de Medicación , Femenino , Humanos , Masculino , Persona de Mediana Edad , Centros de Control de Intoxicaciones , Intoxicación/tratamiento farmacológico , Guías de Práctica Clínica como Asunto , Estudios Retrospectivos , Resultado del Tratamiento , Adulto Joven