RESUMEN
Complex application of lisinopril (inhibitor of angiotensin-converting enzyme) and lovastatin (inhibitor of HMG-CoA reductase) inhibits pancreatic fibrosis in the rats, having alcoholic chronic pancreatitis after distal pancreatic resection (DPR). Lisinopril and lovastatin were injected to the rats after DPR in dose 10 mg/kg during 3 weeks. Immunohistochemical markets, such as alpha-smooth-muscle actin (alpha-SMA), desmin, glial fibrillary acidic protein (GFAP), vimentin, and expression of matrix metalloproteinase-1 (MMP-1) as well as inhibitor of matrix metalloproteinase-2 (TIMP-2) were detected for estimation of therapeutic impact on activity and quantity of stellate pancreatic cells. Under the influence of lisinopril and lovastatin there were observed lowering in the stellate pancreatic cells activity and in expression of SMA, desmin, GFAP, vimentin and TIMP-2, the MMP-1 and TIMP-2 ratio have had increased significantly and severity of fibrotic pancreatic affection had reduced trustworthy in comparison w such, occurring in a control group.
Asunto(s)
Inhibidores de la Enzima Convertidora de Angiotensina/farmacología , Inhibidores de Hidroximetilglutaril-CoA Reductasas/farmacología , Lisinopril/farmacología , Lovastatina/farmacología , Pancreatitis Alcohólica/tratamiento farmacológico , Actinas/genética , Actinas/metabolismo , Animales , Biomarcadores/metabolismo , Desmina/genética , Desmina/metabolismo , Femenino , Fibrosis/prevención & control , Expresión Génica/efectos de los fármacos , Proteína Ácida Fibrilar de la Glía/genética , Proteína Ácida Fibrilar de la Glía/metabolismo , Metaloproteinasa 1 de la Matriz , Páncreas/efectos de los fármacos , Páncreas/metabolismo , Páncreas/patología , Pancreatectomía , Células Estrelladas Pancreáticas/efectos de los fármacos , Células Estrelladas Pancreáticas/metabolismo , Células Estrelladas Pancreáticas/patología , Pancreatitis Alcohólica/genética , Pancreatitis Alcohólica/metabolismo , Pancreatitis Alcohólica/patología , Ratas , Ratas Wistar , Inhibidor Tisular de Metaloproteinasa-2/genética , Inhibidor Tisular de Metaloproteinasa-2/metabolismo , Vimentina/genética , Vimentina/metabolismoRESUMEN
Experience of treatment of 105 patients, operated for the abdominal organs diseases, owing various degree of risk of an acute postoperative pancreatitis (APOP) occurrence, was summarized. Octrestatin was injected perioperatively in patients of the main group, in a control group it was not applied. Complex pancreatoprotective therapy was conducted in patients of both groups. In prophylactic application of octrestatin the trustworthy APOP occurrence frequency reduction was noted.
Asunto(s)
Cavidad Abdominal/cirugía , Colelitiasis/cirugía , Pancreatitis/prevención & control , Complicaciones Posoperatorias/prevención & control , Somatostatina/análogos & derivados , Somatostatina/uso terapéutico , Cavidad Abdominal/patología , Enfermedad Aguda , Adulto , Anciano , Colecistectomía Laparoscópica , Colelitiasis/complicaciones , Colelitiasis/tratamiento farmacológico , Colelitiasis/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pancreatitis/tratamiento farmacológico , Pancreatitis/etiología , Periodo Posoperatorio , Somatostatina/administración & dosificaciónRESUMEN
Epidemiology of complex and recurrent inguinal hernias, the stages of rising of conventional and laparoscopic hernioplasty, modern synthetic plastic materials were analyzed. The methods of transabdominal preperitoneal hernioplasty (TAPP) and extraperitoneal hernioplasty (TEP) performance are depicted. The results of laparoscopic hernioplasty, performed in 112 patients for complex and recurrent inguinal hernias in the Department of Laparoscopic Surgery and Choledocholithiasis in 1997-2009, are analyzed.
Asunto(s)
Hernia Inguinal/cirugía , Laparoscopía/métodos , Cirugía Asistida por Video/métodos , Adulto , Anciano , Femenino , Hernia Inguinal/diagnóstico , Hernia Inguinal/prevención & control , Humanos , Masculino , Persona de Mediana Edad , Prevención Secundaria , Resultado del TratamientoRESUMEN
Outcomes of pancreatoduodenectomies performed during the period from 1996 to 2008 in 110 patients with malignant diseases of pancreaticoduodenal zone and complicated forms of chronic pancreatitis with predominant changes of the pancreatic head were presented. Age of patients ranged from 17 to 73 years, on average (52.0 +/- 9.97) years. Primary aspects of pancreatoduodenal complex dissection and technique of reconstructive stage of the procedure are given. Use of transplantational technologies allowed significant decrease in complications total rate from 30.3 to 18.2%, and pancreatic anastomosis insufficiency one--from 24.2 to 5.2%. Total duration of the procedure decreased from (510.7 +/- 66.12) to (352.9 +/- 50.05) min, intraoperative blood loss--from (860.6 +/- 167.59) to (480.4 +/- 163.61) ml and postoperative hospital stay - from (30.12 +/- 24.32) to (18.2 +/- 9.98) days. After the operation all the patients are alive.
Asunto(s)
Neoplasias del Sistema Biliar/cirugía , Neoplasias Duodenales/cirugía , Neoplasias Pancreáticas/cirugía , Pancreaticoduodenectomía/métodos , Pancreatitis Crónica/cirugía , Adolescente , Adulto , Anciano , Anastomosis Quirúrgica/métodos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pancreaticoduodenectomía/efectos adversos , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Estudios Retrospectivos , Técnicas de Sutura , Resultado del Tratamiento , Adulto JovenRESUMEN
In 2002-2008 yrs. in the Department of Laparoscopic Surgery and Cholelithiasis in 52 patients laparoscopic adrenalectomy (LA) was accomplished, performed for different diseases of suprarenal glands. Incidentaloma was diagnosed in 8, fibroma--in 4, pheokhromocytoma--in 10, aldosteroma--in 11, adrenocortical cancer--in 3, corticosteroma--in 13, suprarenal gland cyst--in 3 patients. The operation time in right-sided and left-sided LA had constituted accordingly 85 and 118 minutes. Intraoperative blood loss had constituted 60 ml at average. Hemotransfusion was not done. In 1 (2.4%) observation hemoperitoneum had occurred as a result of traumatic damage of spleen during performance of left-sided LA. Intraoperative complications were absent. The stationary treatment duration was 2.6 days at average.