RESUMEN
Children and adolescents with an unfavourable course of epilepsy received a multiple modality treatment including complamin (xantinolnicotinate). Thirty of the 36 patients showed positive response which was twice as much as in patients receiving only anticonvulsive drugs. The study of the cerebral hemodynamics with the help of regional cerebral blood flow determination by means of intravenous administration of 133Xe and REG showed a tendency to normalization of the vascular supply to the brain. In 66 of the 87 epileptic patients studied the employment of diazepam improved the microcirculation of the cerebral tissue and the venous outflow from the cranial cavity which allows the recommendation of diazepam as a vasoactive agent.
Asunto(s)
Trastornos Cerebrovasculares/tratamiento farmacológico , Diazepam/uso terapéutico , Epilepsia/complicaciones , Teofilina/análogos & derivados , Niacinato de Xantinol/uso terapéutico , Adolescente , Anticonvulsivantes/uso terapéutico , Encéfalo/irrigación sanguínea , Trastornos Cerebrovasculares/fisiopatología , Niño , Quimioterapia Combinada , Epilepsia/fisiopatología , Femenino , Humanos , Masculino , Pletismografía de Impedancia , Flujo Sanguíneo Regional , Radioisótopos de XenónRESUMEN
133Xe clearance and REG were used in 90 children and adolescents with epilepsy to study pMK, pMCC and the responsiveness of the cerebral vessels in the interparoxysmal period. If the disease takes a relatively favourable course, there is a compensatory intensification of the blood flow in the area of epileptic foci whereas in patients with an unfavourable course, marked chronic dyscirculatory hypoxia and disorders of the responsiveness of the cerebral vessels indicate the decompensation of the vascular component and, possibly, the primary organically induced insufficiency of the brain blood supply.
Asunto(s)
Encéfalo/irrigación sanguínea , Epilepsia/fisiopatología , Adolescente , Presión Sanguínea , Corteza Cerebral/irrigación sanguínea , Niño , Preescolar , Epilepsia/diagnóstico , Femenino , Humanos , Masculino , Pletismografía de Impedancia , Pronóstico , Flujo Sanguíneo Regional , Resistencia Vascular , Radioisótopos de XenónRESUMEN
The authors describe the clinical picture of hereditary purinosis with predominantly psychopathological manifestations in 12 boys, aged 12-15 years, identified among slightly oligophrenic children on the basis of the psychopathological similarity with the classical Lesh-Nyhan syndrome and the determination of the activity of purine phosphoribosyl transferases in erythrocyte lysates. The authors believe that diagnostically significant in such cases is a specific complex of disorders at the instinctive-emotional, psychomotor and intellectual levels. They also claim that this variant of hereditary purinosis is more prevalent than the classical one.
Asunto(s)
Trastornos Mentales/genética , Errores Innatos del Metabolismo de la Purina-Pirimidina/diagnóstico , Adenina Fosforribosiltransferasa/sangre , Agresión , Niño , Humanos , Hipoxantina Fosforribosiltransferasa/sangre , Discapacidad Intelectual/genética , Síndrome de Lesch-Nyhan/diagnóstico , Masculino , SíndromeRESUMEN
The levels of blood serotonin and the urinary concentrations of 5-HIAA, DOPA, dopamine, adrenaline as well as the products of their conversion and disintegration were assessed in 104 oligophrenic patients of different age with different genesis (phenylketonurea, Down's disease, mental retardation of residual organic origin including the complicated syndrome of early childhood autism). The results obtained showed peculiar deviations in serotonin and catecholamine metabolism in each of the diseases, which were independent of the degree of mental retardation. Clinical-biochemical parallels point to considerable differences in the mechanisms of the revealed metabolic digressions in the studied forms of psychic retardation.
Asunto(s)
Aminas Biogénicas/metabolismo , Discapacidad Intelectual/metabolismo , Adolescente , Trastorno Autístico/metabolismo , Niño , Preescolar , Dihidroxifenilalanina/orina , Dopamina/orina , Síndrome de Down/metabolismo , Epinefrina/orina , Humanos , Lactante , Norepinefrina/orina , Fenilcetonurias/metabolismo , Serotonina/sangreRESUMEN
The author presents the data of 4- to 25-year-long observation of a group of boys distinguished since the early age by a pronounced disproportionaity of the psychic development: an accelerated development of abstract-logical thinking with gross defects of sensuous perception, emotions, psychomotor functions, and adaptive behaviour as a whole. Despite the evolutional course of the state most of the patients appeared to be unable to independent social adaptation. The degree and structure of this disharmonic underdevelopment allow one to regard this pathology as a variant of nervous system dysontogenesis differing from, but bordering on such forms as Kanner's autism, Asperger's psychopathy, or mental retardation with partial giftedness.