RESUMEN
PURPOSE: The etiology of sinonasal polyps is sometimes obscure. This study was undertaken to evaluate the potential role of arachidonic acid metabolites (AAm) on recurrent polyposis. MATERIALS AND METHODS: Tissue production of prostaglandin E2 (PGE2), 6-keto-prostaglandin F1-alpha (PGI2), thromboxane A2 (TxA2), and leukotriene C4 (LTC4) by nasal mucosa was determined by radioimmunoassay in 27 patients with sinonasal polyposis (SNp) and in 10 volunteers. RESULTS: The group of patients with SNp with the evidence of recurrences in postoperative period (Group 1) showed significantly lower PGE2 concentrations than group of patients with SNp recurrences (Group 2). The differences in concentrations of PGI2 in mentioned groups were insignificant. In comparison with other groups, a group of patients who underwent surgery several times for SNp (Group 4) had a higher mean TxA2 concentration. The LTC4 concentrations were the highest in groups of patients where SNp recurrences were observed. When the incidence of polyposis recurrences (within 18 months after surgery) was correlated with the level of LTC4 production at the time of surgery, the rate of recurrence was significantly higher in patients with increased LTC4 level than in those with normal LTC4 levels. CONCLUSIONS: LTC4 might have a prognostic value. The possible role of AAm in occurrence of SNp is apparent and suggests possible role for medical intervention.
Asunto(s)
Ácidos Araquidónicos/metabolismo , Pólipos Nasales/metabolismo , Neoplasias de los Senos Paranasales/metabolismo , Pólipos/metabolismo , 6-Cetoprostaglandina F1 alfa/análisis , 6-Cetoprostaglandina F1 alfa/metabolismo , Adulto , Anciano , Ácidos Araquidónicos/análisis , Biomarcadores de Tumor/análisis , Biomarcadores de Tumor/metabolismo , Dinoprostona/análisis , Dinoprostona/metabolismo , Epoprostenol/análisis , Epoprostenol/metabolismo , Femenino , Humanos , Incidencia , Leucotrieno C4/análisis , Leucotrieno C4/metabolismo , Masculino , Persona de Mediana Edad , Mucosa Nasal/metabolismo , Pólipos Nasales/patología , Recurrencia Local de Neoplasia/metabolismo , Recurrencia Local de Neoplasia/patología , Neoplasias de los Senos Paranasales/patología , Pólipos/patología , Pronóstico , Tromboxano A2/análisis , Tromboxano A2/metabolismoRESUMEN
Sham-gonadectomized and gonadectomized male and female mice were given methylcholanthrene s.c. to assess the influence of sex hormones on carcinogenesis. Gonadectomy decreased the concentration of the respective sex hormone and increased the concentration of the opposite sex hormone. The results showed that androgens enhanced the effectiveness of carcinogenesis, while estrogens had the opposite effect. Gonadectomy effectively abrogated the sex differences in tumor induction.
Asunto(s)
Castración , Neoplasias Experimentales/inducido químicamente , Animales , Estradiol/sangre , Femenino , Masculino , Metilcolantreno , Ratones , Ratones Endogámicos CBA , Caracteres Sexuales , Testosterona/sangreRESUMEN
The protective effect of interleukin 1 alpha (IL-1 alpha) in mice with acetaminophen (AAP)-induced hepatitis was investigated. IL-1 alpha had a significant protective effect if given 2 or more hours (up to 24 hours) before AAP; it significantly reduced mortality of mice and decreased serum transaminase level. The maximal effect was obtained with the dose of 1000 U (166 ng/kg) IL-1 alpha. Pretreatment with IL-1 significantly increased the synthesis of prostaglandin E2 (PGE2) in samples of liver tissue from AAP-treated mice, but had no effect on the synthesis of leukotriene C4 (LTC4). Pretreatment with indomethacin (IMC) did not abrogate significantly the protective effect of IL-1. Thus, the hepatoprotective effect of IL-1 alpha can not be entirely explained by the stimulation of prostaglandin (PG) synthesis.
Asunto(s)
Acetaminofén/toxicidad , Hepatitis Animal/prevención & control , Interleucina-1/farmacología , Hígado/efectos de los fármacos , Alanina Transaminasa/sangre , Animales , Aspartato Aminotransferasas/sangre , Dinoprostona/biosíntesis , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Femenino , Hepatitis Animal/inducido químicamente , Indometacina/farmacología , Interleucina-1/administración & dosificación , Interleucina-1/uso terapéutico , Leucotrieno C4/biosíntesis , Hígado/metabolismo , Hígado/patología , Masculino , Ratones , Ratones Endogámicos CBARESUMEN
Sodium aminoalkanesulfonates were synthesized from substituted amines and aldehyde sodium bisulfites at 40-60 degrees. Nitrosation yielded the corresponding N-nitroso derivatives. Mitodepressive activity on cresse (Lepidium sativum L.) was determined, and all compounds examined possessed growth inhibition activity. The N-nitroso derivatives were slightly less active but also showed less toxicity than the parent aminoalkanesulfonic acids.