RESUMEN
Aim to identify outdated terms and make changes to the terminology of spondyloarthritis. MATERIALS AND METHODS: At the first stage of the work, the terms divided into two categories: "outdated" definitions and terms that need to be improved or unified. Subsequently, each member of the Expert Group of Spondyloarthritis at the Association of Rheumatologists of Russia (ExSpA) presented by its own definition of the designated term or agreed with the previous term. At the next stage, the existing definitions were put together. After discussion, experts left a term that scored at least 2/3 of the votes. The special opinion of experts was recorded, whose did not coincide with the majority opinion. An open vote was conducted, when defining an "outdated" term with the unanimous decision of all group members, this term was not recommended for further clinical use. RESULTS: The work carried out allowed us to identify a number of terms that are not recommended for use in clinical practice. Number of terms are defined, which should be used when discussing the problem of spondyloarthritis. CONCLUSION: The Expert Group of Spondyloarthritis at the Association of Rheumatologists of Russia suggests using or, accordingly, not using a number of terms and their definitions in clinical practice.
Asunto(s)
Espondiloartritis , Humanos , Federación de Rusia , Espondiloartritis/diagnóstico , Terminología como AsuntoRESUMEN
The level of cholesterol and its distribution by the fractions of lipoproteins of different classes were studied in the dwellers of an industrial town. The persons living in the residential areas characterized by a high oxidative stress were observed to have higher blood cholesterol levels and dyslipoproteinemia.
Asunto(s)
Hipercolesterolemia/epidemiología , Industrias , Estrés Oxidativo/fisiología , Población Urbana/estadística & datos numéricos , Humanos , Prevalencia , Federación de Rusia/epidemiologíaRESUMEN
AIM: To evaluate effects of an ACE inhibitor captopril on intrarenal hemodynamics during acute test in patients with lupus nephritis (LN) and chronic sclerodermic nephropathy (CSN). MATERIAL AND METHODS: Renal hemodynamics was studied using ultrasound duplex scanning of renal vessels (UDS) on Vingmed SD-100 unit in 5 patients with SLE with renal affection, 5 patients with scleroderma systematica (SS) with renal affection. The hemodynamic parameters were measured before and 1 hour after administration of 50 mg captopril. RESULTS: LN were found to have low arterial perfusion. CSN patients exhibited low intrarenal blood flow in high resistance of small vessels. Captopril improved intrarenal hemodynamics (enhancement of linear and volume blood flow) in LN patients; in CSN renal artery dilated and resistance of small vessels reduced while renal arterial perfusion increased. CONCLUSION: Improvement of intrarenal hemodynamics in LN and CSN patients in response to captopril allows to recommend administration of ACE inhibitors in SLE and SS with renal damage. Ultrasonic duplex scanning of renal vessels provides detailed information about the condition of intrarenal vessels without invasion.
Asunto(s)
Inhibidores de la Enzima Convertidora de Angiotensina/farmacología , Antihipertensivos/farmacología , Captopril/farmacología , Riñón/efectos de los fármacos , Nefritis Lúpica/tratamiento farmacológico , Sistema Renina-Angiotensina/efectos de los fármacos , Esclerodermia Sistémica/tratamiento farmacológico , Inhibidores de la Enzima Convertidora de Angiotensina/administración & dosificación , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Antihipertensivos/administración & dosificación , Antihipertensivos/uso terapéutico , Captopril/administración & dosificación , Captopril/uso terapéutico , Femenino , Hemodinámica , Humanos , Riñón/irrigación sanguínea , Riñón/diagnóstico por imagen , Riñón/fisiopatología , Nefritis Lúpica/diagnóstico por imagen , Nefritis Lúpica/fisiopatología , Masculino , Persona de Mediana Edad , Esclerodermia Sistémica/diagnóstico por imagen , Esclerodermia Sistémica/fisiopatología , Programas Informáticos , Ultrasonografía Doppler DúplexRESUMEN
AIM: To study intrarenal hemodynamics (IRHD) in patients with systemic lupus erythematosus (SLE) and sclerodermia systematical (SS). MATERIALS AND METHODS: IRHD was studied in 30(28 females and 2 males) and 25(22 females and 3 males) patients with SLE and SS, respectively, and mean duration of the disease 5.6 +/- 0.5 and 7.5 +/- 1.2 years, respectively. Lupus nephritis was diagnosed in 21(70%), sclerodermic nephropathy in 10(40%) patients. Patients with chronic renal failure were not included. IRHD was investigated using protein loading which provided the index of functional renal reserve (FRR). RESULTS: Impaired IRHD was detected in 21(70%) patients with SLE. 19 patients had lupus nephritis. FRR depletion was found also in 2 patients free of lupus nephritis symptoms. 10 of them (8 with active nephritis and 2 with intact kidneys) had arterial hypertension. FRR depletion was found also in 12(48%) of SS patients. 7 of them had sclerodermic renal lesions. CONCLUSION: Impaired IRHD was encountered frequently both in SLE and SS patients and can develop in the absence of renal affection symptoms.