Asunto(s)
Glucemia/metabolismo , Diabetes Mellitus Tipo 1/tratamiento farmacológico , Diabetes Mellitus Tipo 2/tratamiento farmacológico , Insulina/farmacología , Metabolismo de los Lípidos , Adulto , Anciano , Diabetes Mellitus Tipo 1/metabolismo , Diabetes Mellitus Tipo 2/metabolismo , Femenino , Hemoglobina Glucada/análisis , Humanos , Insulina/administración & dosificación , Masculino , Persona de Mediana Edad , Factores de TiempoRESUMEN
The aim of the present paper was to evaluate the effect of the 1,4 bis [3-(3,4,5-trimethoxybenzoyl-oxy) propyl] perhydro-1,4 diazepina (dilazep) on reduction of circulating platelet aggregates in 18 patients with type 2 diabetes, 13 female and 5 male, aged 25-65 years. Dilazep was orally given at 100 mg X 3/day for 8 weeks. The platelet activity has valued before and after the treatment trough the evaluation of circulating platelet aggregates with the method of Wu and Hoak. The results confirmed that the dilazep decreased statistically significant after 8 weeks the circulating aggregates.
Asunto(s)
Azepinas/farmacología , Diabetes Mellitus Tipo 2/sangre , Dilazep/farmacología , Agregación Plaquetaria/efectos de los fármacos , Administración Oral , Adulto , Anciano , Dilazep/administración & dosificación , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
We have investigated the effect of dilazep on the prostaglandin synthesis determined as indicator malondialdehyde (MDA) formation. Twenty patients with type 2 diabetes, aged 25-65 years were orally given dilazep at 100 mg X 3/day for 56 daily. The platelet activity has valued before and after the treatment with the production of the MDA. We conclude that the dilazep inhibited statistically significant biosynthesis of prostaglandin endoperoxides from arachidonic acid.
Asunto(s)
Azepinas/farmacología , Plaquetas/metabolismo , Diabetes Mellitus Tipo 2/sangre , Dilazep/farmacología , Malonatos/sangre , Malondialdehído/sangre , Adulto , Anciano , Plaquetas/efectos de los fármacos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Endoperóxidos de Prostaglandina/sangreRESUMEN
We have investigated in 400 patients, 159 male and 241 female, mean age 58 years, with type 2 diabetes, the incidence of peptic ulcer and on 127 patients with peptic ulcer, the incidence of diabetes mellitus. In conclusion the incidence of peptic ulcer is no more than 3,9% in diabetic patients. In peptic ulcer the female to male ratio is 1:0,9. The seat of the ulcer is resulted to be in ratio of 1,4:1 more in the duodenal tract than in the gastric tract. The result are attributed to the increased secretion of the gastrointestinal hormones (Bombesin and Somatostatin) in the diabetic patients. However the neuromodulator of gastrointestinal hormones release is mediated of the Dorsal Motor nucleus of the Vagus nerve connected to the endocrine pancreas exclusively via vagal fibers and has a role in neurally mediated insulin release.