RESUMEN

OBJECTIVES: To assess the accuracy and interobserver agreement of tele-ultrasonography for the diagnosis of gastrointestinal obstruction in small animals by radiologists with different levels of experience. MATERIALS AND METHODS: A retrospective cross-sectional study including dogs and cats admitted with gastrointestinal signs, between 2017 and 2019, that had abdominal ultrasonographic (US) examination performed and images saved for review. Patients were classified into two categories based on final diagnosis: animals with or without complete or partial gastrointestinal obstruction. Observers with four experience levels interpreted the archived ultrasound examinations, simulating a tele-ultrasonography consultation. Analyses of accuracy, sensitivity, specificity, positive and negative predictive values were obtained for each observer for detection of gastrointestinal obstruction. Agreement between observers for the gastrointestinal obstruction diagnosis was assessed using Fleiss's Kappa statistics. RESULTS: Ninety patients with gastrointestinal signs were included. Of these, 23 of 90 had partial or complete gastrointestinal obstruction. Interpretation of the images by observers via tele-ultrasonography showed intervals of accuracy, sensitivity, specificity, positive and negative predictive values, respectively, of 78.9% to 87.8%, 73.9% to 100%, 77.6% to 89.6%, 55.9% to 70.8% and 90.9% to 100% for diagnosis of gastrointestinal obstruction. Agreement for the gastrointestinal obstruction diagnosis across all reviewers was moderate (Kappa 0.6). CLINICAL SIGNIFICANCE: Tele-ultrasonography had good accuracy for detection of gastrointestinal obstruction, however had a rather low positive predictive value and only moderate interobserver agreement. Therefore, this technique should be used with caution in this clinical context, given the potential surgical decision at hand.

Asunto(s)

Enfermedades de los Gatos , Enfermedades de los Perros , Obstrucción Intestinal , Gatos , Perros , Animales , Estudios Retrospectivos , Enfermedades de los Gatos/diagnóstico por imagen , Reproducibilidad de los Resultados , Estudios Transversales , Enfermedades de los Perros/diagnóstico por imagen , Obstrucción Intestinal/diagnóstico por imagen , Obstrucción Intestinal/veterinaria , Ultrasonografía/veterinaria , Sensibilidad y Especificidad , Variaciones Dependientes del Observador

RESUMEN

Protein core repacking is a standard test of protein modeling software. A recent study of six different modeling software packages showed that they are more successful at predicting side chain conformations of core compared to surface residues. All the modeling software tested have multicomponent energy functions, typically including contributions from solvation, electrostatics, hydrogen bonding and Lennard-Jones interactions in addition to statistical terms based on observed protein structures. We investigated to what extent a simplified energy function that includes only stereochemical constraints and repulsive hard-sphere interactions can correctly repack protein cores. For single residue and collective repacking, the hard-sphere model accurately recapitulates the observed side chain conformations for Ile, Leu, Phe, Thr, Trp, Tyr and Val. This result shows that there are no alternative, sterically allowed side chain conformations of core residues. Analysis of the same set of protein cores using the Rosetta software suite revealed that the hard-sphere model and Rosetta perform equally well on Ile, Leu, Phe, Thr and Val; the hard-sphere model performs better on Trp and Tyr and Rosetta performs better on Ser. We conclude that the high prediction accuracy in protein cores obtained by protein modeling software and our simplified hard-sphere approach reflects the high density of protein cores and dominance of steric repulsion.

Asunto(s)

Bases de Datos de Proteínas , Modelos Moleculares , Proteínas/química , Programas Informáticos , Dominios Proteicos , Proteínas/genética

RESUMEN

Acute optic neuritis (ON) is the initial presentation in half of neuromyelitis optica spectrum disorder (NMO-SD) cases. Our objective was to evaluate accuracy of combined MRIs of the anterior visual pathways and of the brain to correctly identify NMO-SD among patients with acute ON. We performed a retrospective study on patients with acute ON in NMO-SD (16 episodes) and first-event non-NMO-SD (32 episodes). All MRIs included exams of the brain and anterior visual pathways using T2-weighted and post-gadolinium T1-weighted coronal thin slices. Images were reviewed by a neuroradiologist who was blinded to the final diagnosis. There were no multiple sclerosis (MS)-like lesions with dissemination in space (DIS) with NMO-SD (0 vs. 53%, p < 0.01). Non-NMO-SD ON usually spared the chiasma (3 vs. 44%, p < 0.01) and the optic tracts (0 vs. 19%, p < 0.01). Optic nerve lesions were longer [median (range) 26 mm (14-64) vs. 13 mm [8-36], p < 0.01] and the number of segments involved higher (3 [1-8] vs. 1 [1-4], p < 0.01) in NMO-SD. Bilateral optic nerve involvement, or involvement of ≥3 segments, or involvement of the chiasma, or optic tracts in the absence of MS-like lesions with DIS were suggestive of NMO-SD with a sensitivity of 69% (CI 95% 41-89) and a specificity of 97% (CI 95% 84-99) (p < 0.01). Combining brain and anterior visual pathways' MRIs seems efficient for detecting acute ON patients who are at high risk for NMO-SD.

Asunto(s)

Neuroimagen/métodos , Neuromielitis Óptica/diagnóstico por imagen , Neuritis Óptica/diagnóstico por imagen , Adolescente , Adulto , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Neuromielitis Óptica/complicaciones , Neuritis Óptica/etiología , Estudios Retrospectivos , Vías Visuales/diagnóstico por imagen , Adulto Joven

RESUMEN

To evaluate the effects of bioactive molecules in pulpal wound healing, we carried out experiments using the rat upper molars as an in vivo model. Cavities were prepared on the mesial aspect, and pulp perforation was accomplished by the application of pressure with the tip of a steel probe. After the pulp-capping procedure, the cavities were filled with a glass-ionomer cement. Comparison was made between and among: (1) sham-operated controls with dentin and predentin fragments implanted in the pulp during perforation after 8, 14, and 28 days; (2) carrier without bioactive substance; (3) calcium hydroxide; (4) Bone Sialoprotein (BSP); (5) different concentrations of Bone Morphogenetic Protein-7 (BMP-7), also termed Osteogenic Protein-1 (OP-1); and (6) N-Acetyl Cysteine (NAC), an anti-oxidant agent preventing glutathione depletion. Histologic and morphometric comparison, carried out among the first 4 groups on demineralized tissue sections, indicated that, at 28 days after implantation, BSP was the most efficient bioactive molecule, inducing homogeneous and well-mineralized reparative dentin. BMP-7 gave reparative dentin of the osteodentin type in the coronal part of the pulp, and generated the formation of a homogeneous mineralized structure in the root canal. These findings indicate that the crown and radicular parts of the pulp bear their own specificity. Both BSP and BMP-7 were superior to calcium hydroxide in their mineralization-inducing properties, and displayed larger areas of mineralization containing fewer pulp tissue inclusions. The overall mineralization process to these molecules appeared to proceed by mechanisms that involved the recruitment of cells which differentiate into osteoblast-like cells, producing a mineralizing extracellular matrix. We also provide preliminary evidence that NAC induces reparative dentin formation in the rat molar model. Pulp-capping with bioactive molecules provides new prospects for dental therapy.

Asunto(s)

Materiales Biocompatibles/uso terapéutico , Recubrimiento de la Pulpa Dental , Acetilcisteína/uso terapéutico , Animales , Antioxidantes/uso terapéutico , Proteína Morfogenética Ósea 7 , Proteínas Morfogenéticas Óseas/uso terapéutico , Hidróxido de Calcio/uso terapéutico , Pulpa Dental/efectos de los fármacos , Pulpa Dental/patología , Cavidad Pulpar/efectos de los fármacos , Cavidad Pulpar/patología , Exposición de la Pulpa Dental/terapia , Restauración Dental Permanente , Dentina/efectos de los fármacos , Dentina/patología , Dentina/fisiología , Dentina Secundaria/efectos de los fármacos , Dentina Secundaria/patología , Dentinogénesis/efectos de los fármacos , Depuradores de Radicales Libres/uso terapéutico , Cementos de Ionómero Vítreo , Sialoproteína de Unión a Integrina , Masculino , Vehículos Farmacéuticos , Ratas , Ratas Sprague-Dawley , Sialoglicoproteínas/uso terapéutico , Factores de Tiempo , Factor de Crecimiento Transformador beta/uso terapéutico , Cicatrización de Heridas/efectos de los fármacos

RESUMEN

Bone sialoprotein (BSP), an osteogenic protein (OP), mixed with a carrier, was implanted in the pulp of rat first upper molars (OP group). Cavities were prepared with dental burs and pulp perforation was carried out by pressure with the tip of a steel probe. After 8, 14, and 30 days, the rats were killed and the pulps of the OP group were compared with (1) a sham group (S group), (2) a group where the carrier was implanted alone (C group), and (3) capping with calcium hydroxide (Ca group). After 8 days, a few inflammatory cells were seen, mostly located at the pulp surface near the perforation. In the Ca group, a dentin bridge started to form, in contrast to the other groups. After 15 days, globular structures were seen in the pulps of the S and C groups. A reparative osteodentin bridge isolated the pulp from the cavity in the Ca group. Variable reactions were seen in the OP group, with some evidence of cell and matrix alignments or plugs of osteodentin in continuity with an inner layer of reparative dentin. After 30 days, irregular osteodentin formation was observed in the pulps of the S and C groups, with a tendency for globular structures to merge, but with interglobular spaces filled by pulp remnants. In the Ca group, osteodentin was observed in the mesial part of the pulp chamber. In the BSP-implanted group, the osteogenic protein stimulated the formation of a homogeneous dentin-like deposit occupying most of the mesial part of the pulp. Apparently, BSP stimulates the differentiation of cells which secrete an organized extracellular matrix more efficiently than any other capping material used so far. Altogether, the results reported here support that bone sialoprotein displays novel bioactive properties and is capable of stimulating in 1 month's time the development of a thick reparative dentinal tissue in the pulp, occluding the perforation and filling the mesial third of the pulp chamber.

Asunto(s)

Pulpa Dental/efectos de los fármacos , Dentinogénesis/efectos de los fármacos , Sialoglicoproteínas/uso terapéutico , Animales , Calcificación Fisiológica , Hidróxido de Calcio/uso terapéutico , Diferenciación Celular/efectos de los fármacos , Colágeno/uso terapéutico , Recubrimiento de la Pulpa Dental , Cavidad Pulpar/efectos de los fármacos , Exposición de la Pulpa Dental/terapia , Dentina Secundaria/inducido químicamente , Modelos Animales de Enfermedad , Portadores de Fármacos , Matriz Extracelular/efectos de los fármacos , Estudios de Seguimiento , Gelatina , Cementos de Ionómero Vítreo , Sialoproteína de Unión a Integrina , Diente Molar , Odontoblastos/efectos de los fármacos , Ratas , Ratas Sprague-Dawley , Materiales de Obturación del Conducto Radicular

RESUMEN

STUDY DESIGN: A study of inter- and intra-examiner reliability and clinical validity using two instruments for assessment of spinal range of motion in healthy individuals. OBJECTIVE: To assess the clinical validity, stability, and normative values for active and passive cervical range of motion as measured by the CA-6000 (Orthopedic Systems Inc., Union City, CA), an electrogoniometer. SUMMARY OF BACKGROUND DATA: The authors' early trials with the electrogoniometer yielded values that differed substantially from those in other reports. The authors sought to resolve those discrepancies and understand their sources. METHODS: Axial rotations along the transverse, coronal, and frontal planes were measured as half-cycles (i.e., left-right or flexion-extension) that were repeated seven times per trial. Test-retest data were collected on the same healthy individuals for active and passive motion using men and women aged 20-39 years. For validity, simultaneous digital dual inclinometry and electrogoniometry were performed twice over a 1-week interval. In addition, a bench test was performed for validation of axial rotation. RESULTS: Clinical reliability of the CA-6000 was high for inter- and intra-examiner studies of total active motion, and validity was high when compared with that obtained with dual inclinometry. Total range of motion had less between-trial variability than half-cycles, axial rotation and lateral bending measurements had greater reliability than did flexion-extension measurements, and active motion was more reliable than passive motion. CONCLUSION: The CA-6000 provides valid and reliable measures of cervical range of motion. Discrepancies reported elsewhere appear to have arisen from several sources, as discussed in this article.

Asunto(s)

Vértebras Cervicales/fisiología , Rango del Movimiento Articular/fisiología , Adulto , Envejecimiento/fisiología , Electrodiagnóstico/instrumentación , Femenino , Humanos , Masculino , Variaciones Dependientes del Observador , Dimensión del Dolor , Postura/fisiología , Valores de Referencia , Reproducibilidad de los Resultados

RESUMEN

OBJECTIVE: To assess the results of Martius' labial fat pad interposition and its modification using skin island in the repair of giant and recurrent vesicovaginal and urethrovaginal fistulae. PATIENTS AND METHODS: Fifteen patients of urethrovaginal and vesicovaginal fistulae underwent Martius' labial fat pad interposition and its skin island modification during 1996 to 1999. Ten of these were recurrent (66%) and five were giant fistulae (34%) i.e. more than five cms. RESULTS: Results were very gratifying with a successful repair in 14 patients (93%). Two patients had transient, low-grade stress incontinence, which did not need any additional procedure. In one patient, there was failure of repair, which was later successfully repaired using fat pad from opposite labia. CONCLUSION: Martius' fat pad interposition provides vascularity and surface for epithelialisation and also prevents overlapping of vesical/urethral and vaginal suture lines. Martius' repair has good results with low morbidity in the treatment of giant and recurrent urethrovaginal and vesicovaginal fistulae.

Asunto(s)

Colgajos Quirúrgicos , Enfermedades Uretrales/cirugía , Fístula Urinaria/cirugía , Fístula Vesicovaginal/cirugía , Femenino , Humanos , Recurrencia

RESUMEN

Titanium is used in dentistry for implants and frame work because of its sufficient chemical, physical and biological properties. The corrosion behaviour is from high interest to value biocompatibility. A static immersion test was undertaken with a titanium test specimen (30 mm x 10 mm x 1 mm, immersion time = 4 x 1 w, n = 3 for each series). The following parameters were investigated: specimen preparation, grinding, pH-value, different casting systems, comparison with CAD/CAM, influence of: chloride, thiocyanate, fluoride, lactate, citrate, oxalate, acetate. Atomic absorption spectroscopy was used to analyse the solutions weekly. The course of corrosion was investigated photometrically. Titanium reveals ion releases [(0.01-0.1) microg/(cm2 x d)] in the magnitude of gold alloys. There is little influence of grinding and casting systems in comparison with organic acids or pH value. The ion release increases extreme (up to 500 microg/(cm2 x d)) in the presence of fluoride. Low pH values accelerate this effect even more. Clinically, no corrosion effects were observed. Nevertheless it is recommended that it is best to avoid the presence of fluoride or to reduce contact time. In prophylactic fluoridation of teeth, a varnish should be used.

Asunto(s)

Materiales Biocompatibles/química , Titanio/química , Aniones , Fenómenos Químicos , Química Física , Diseño Asistido por Computadora , Corrosión

RESUMEN

To analyze the magnitude of the risk factors for infantile spasms, we evaluated the records of 80 children with infantile spasms, 474 children with other types of epilepsy, 2,196 children with febrile seizures, and 262 children with CNS infections. There was a family history of seizures in 13.8% of children with infaNtile spasms, 28.5% of children with other forms of epilepsy, 25.5% of children with febrile seizures, and 5.3% of children with CNS infections. Children with a family history of seizures were 2.82 times more likely to have infantile spasms, 7.05 time more likely to have other epilepsy, and 6.08 time more likely to have febrile seizures than controls (children with CNS infections). However, a family history of seizures increased the risk for infantile spasms only in the cryptogenic group. Children with infantile spasms were significantly more likely to have cerebral palsy, microcephaly, hydrocephaly, CNS malformations, neonatal hypoxia, or neonatal seizures than children with other types of epilepsy, febrile seizures, or CNS infections. There was a modest genetic predisposition to seizures in children with infantile spasms. However, our data suggest a much stronger association with underlying neurologic abnormalities, mainly neonatal seizures, neonatal hypoxia, and CNS malformations.

Asunto(s)

Convulsiones/epidemiología , Convulsiones/genética , Espasmos Infantiles/epidemiología , Espasmos Infantiles/genética , Factores de Edad , Encéfalo/anomalías , Enfermedades del Sistema Nervioso Central/epidemiología , Enfermedades del Sistema Nervioso Central/genética , Preescolar , Comorbilidad , Epilepsia/epidemiología , Epilepsia/genética , Familia , Femenino , Humanos , Lactante , Masculino , Estudios Retrospectivos , Factores de Riesgo

RESUMEN

In this Danish-Norwegian randomized double-blind parallel-group multicentre study, we compared the therapeutic response of slow-release Madopar HBS to standard Madopar in 134 de novo patients with idiopathic Parkinson's disease during a 5-year period. The drugs were dosed according to the individual need of the patients. The Webster, NUDS, UPDRS and Hoehn & Yahr scales were used for evaluation of symptoms. Addition of a morning dose of standard Madopar 62.5 mg was allowed after 6 months. Bromocriptine could be administered but not Selegiline. Sixty-five patients got Madopar HBS and 69 standard Madopar. Surprisingly, no differences were found as to the mean daily levodopa dose, the mean number of daily doses or the use of the doses of bromocriptine. Unexpectedly, we found a trend towards a more frequent use of a morning dose of standard Madopar in the group treated with the standard formulation. No differences were observed in the occurrence of motor fluctuations or dyskinesia, the incidence of which was relatively low. Sustained-release Madopar (HBS) thus proved to be as effective as standard Madopar in the long-term treatment of de novo parkinsonian patients, but the drug showed no advantage in postponing or reducing the long-term levodopa treatment problems.

Asunto(s)

Antiparkinsonianos/administración & dosificación , Benserazida/administración & dosificación , Levodopa/administración & dosificación , Enfermedad de Parkinson/tratamiento farmacológico , Anciano , Antiparkinsonianos/efectos adversos , Benserazida/efectos adversos , Preparaciones de Acción Retardada , Dinamarca , Relación Dosis-Respuesta a Droga , Método Doble Ciego , Esquema de Medicación , Combinación de Medicamentos , Femenino , Humanos , Levodopa/efectos adversos , Masculino , Persona de Mediana Edad , Examen Neurológico/efectos de los fármacos , Noruega , Enfermedad de Parkinson/diagnóstico

RESUMEN

In a double-blind, randomized, controlled, multicenter clinical trial in general practice, lasting 7 weeks, a fixed dose of moclobemide (400 mg daily) was compared with a fixed dose of clomipramine (150 mg daily). A total of 147 patients with DSM-III-R major depression were included in the study. After a 1-week drug-free washout period, patients were stratified, according to total scores on the Hamilton Rating Scale for Depression (HAM-D), into two groups--HAM-D total scores, 11 to 15 points, and HAM-D total scores, 16 points or more. A comparison of the therapeutic effect of the two treatments was based on HAM-D total scores and the classification of patients into therapeutic response categories defined on the basis of total rating score, complete response, HAM-D < or = 7 points; partial response, HAM-D, 8 to 15 points; or no response, HAM-D > or = 16 points. The Newcastle Diagnostic Rating Scale (1965) was used to classify the patients into two groups, endogenous and nonendogenous. Adverse events were registered by use of the UKU side effect scale. Clinical global assessments of severity, efficacy, and tolerance were completed during the active treatment period. Compliance to treatment was based on levels of the drugs in plasma and the number of returned capsules. One hundred forty-two patients were evaluated for clinical effects. The results of the efficacy analyses showed therapeutic equivalence between moclobemide and clomipramine. There were no differences in the outcome of the two treatment groups or the two diagnostic groups (endogenous and nonendogenous).(ABSTRACT TRUNCATED AT 250 WORDS)

Asunto(s)

Antidepresivos Tricíclicos/efectos adversos , Antidepresivos Tricíclicos/uso terapéutico , Antidepresivos/uso terapéutico , Benzamidas/uso terapéutico , Clomipramina/uso terapéutico , Trastorno Depresivo/tratamiento farmacológico , Adulto , Anciano , Antidepresivos/efectos adversos , Benzamidas/efectos adversos , Clomipramina/efectos adversos , Trastorno Depresivo/psicología , Método Doble Ciego , Medicina Familiar y Comunitaria , Femenino , Humanos , Masculino , Persona de Mediana Edad , Moclobemida , Pacientes Desistentes del Tratamiento , Selección de Paciente , Escalas de Valoración Psiquiátrica

RESUMEN

The viscoelastic properties of three classes of soft relining materials (acrylic resins, silicones, and EVA copolymers) were studied comparatively. Their behaviors were investigated by in vitro tests at a frequency omega = 1 Hz, which stimulates the masticatory cycle. The experimental parameter was the temperature (T). Black graphs giving the variations of the stiffness K--proportional to the complex viscoelastic modulus Ex(T) omega--according to the phase angle delta, were used for a predictive approach to increase the comfort of removable dentures. Cole-Cole diagrams, describing the variation of the loss modulus E"(T) omega in relation to the storage modulus E'(T)omega additionally provide quantitative data. The values obtained were related to the noninteger parameter h used for modelization of the viscoelastic behavior of the materials by means of nonlinear Zener models. An attempt was made to correlate the experimental data to the viscoelastic energy loss observed when instability of the prosthetic structure occurs. This attempt takes into account the formation of "cracks" (areas of inadaptation) between the prosthetic intrados and the mucosa.

Asunto(s)

Materiales Dentales , Prótesis Dental , Resinas Acrílicas , Adhesividad , Elasticidad , Modelos Teóricos , Polivinilos , Siliconas , Propiedades de Superficie , Temperatura , Viscosidad

RESUMEN

This in vitro study evaluated the viscoelastic properties of Permaflex compared to other soft lining materials. The surface condition of this material was also investigated under both laboratory and simulated clinical conditions and with and without the application of a varnish. The tests provided practical instructions for the use of Permaflex, which showed good adaptive properties to stress and surface condition initially and after adjustment.

Asunto(s)

Alineadores Dentales , Dimetilpolisiloxanos/química , Fenómenos Químicos , Química Física , Elasticidad , Laca , Ensayo de Materiales , Propiedades de Superficie , Tecnología Odontológica/métodos , Termodinámica , Viscosidad , Humectabilidad

RESUMEN

In a previous study in which we examined the relationship of pertussis immunization to the onset of neurologic disorders during 1967 and 1968 and during 1972 and 1973 in Denmark, there were 554 children with initial onset of epilepsy and 2158 children with first febrile convulsions. In the study population there were 112 children with epilepsy and 229 children with febrile convulsions for whom the exact date of pertussis immunization and the exact date of the onset of illness were known. We analyzed selected clinical variables by specific time intervals between pertussis immunization and the first seizure. In the children with epilepsy, no relationship was found between time of pertussis immunization and the specific variables that were examined. In contrast, the following characteristics in children with febrile seizures were significantly more common when pertussis immunization had occurred within 3 days, compared with more than 7 days of the event: first seizure more than 10 minutes in duration, the occurrence of more than one seizure, the longest seizure (when there was more than one) more than 10 minutes in duration, and the occurrence of a seizure described as focal. The lack of specific characteristics in epilepsy that had its onset in a temporal relationship to pertussis immunization is further evidence that pertussis vaccine does not cause this disorder. The cause of increased severity of febrile seizures apparently associated with pertussis immunization is unknown.

Asunto(s)

Vacuna contra la Tos Ferina/efectos adversos , Convulsiones/etiología , Humanos , Lactante , Factores de Tiempo

Asunto(s)

Neoplasias/enfermería , Relaciones Enfermero-Paciente , Enfermeras y Enfermeros/psicología , Humanos , Neoplasias/psicología

RESUMEN

Clozapine is the first truly new antipsychotic drug introduced in the last 40 years. Compared to traditional neuroleptic agents, clozapine appears to have a stronger effect on most schizophrenic symptoms. Thus, it seems to be more effective than other agents in severely ill, treatment-resistant patients. Clozapine rarely causes extrapyramidal symptoms such as pseudoparkinsonism or akathisia. To date, no confirmed cases of tardive dyskinesia have been attributed to the drug. Despite these advantages, the usefulness of clozapine is limited by its potentially life-threatening side effects, which include agranulocytosis and respiratory depression.

Asunto(s)

Clozapina/uso terapéutico , Trastornos Psicóticos/tratamiento farmacológico , Agranulocitosis/inducido químicamente , Clozapina/efectos adversos , Clozapina/farmacología , Humanos

Asunto(s)

Equipo Dental , Diseño de Dentadura/instrumentación , Dentadura Parcial Removible , Modelos Dentales , Humanos

Asunto(s)

Retención de Dentadura/instrumentación , Dentadura Parcial Removible , Coronas , Diseño de Dentadura , Humanos

Asunto(s)

Diseño de Dentadura , Retención de Dentadura/instrumentación , Dentadura Parcial Removible , Humanos

RESUMEN

A retrospective epidemiologic study examining the relationship of the time of onset of neurologic disorders with the time of pertussis immunization in two cohorts of children who received pertussis immunization at different ages is reported. Before April 1970, children in Denmark were vaccinated with diphtheria and tetanus toxoids with pertussis vaccine at 5, 6, 7, and 15 months of age. Since 1970, children were given monovalent pertussis vaccine at 5 and 9 weeks and at 10 months of age. A total of 554 cases of epilepsy with onset between 28 days and 24 months of age were reviewed, 286 from the 1967-1968 period and 268 from the 1972-1973 period. There was no relationship between the age of onset of epilepsy and the scheduled age of administration of pertussis vaccine. A total of 2199 children with febrile seizures were reviewed, 830 from the 1967-1968 period and 1369 from the 1972-1973 period. There was a statistical association between first febrile seizures and the scheduled age of administration of pertussis vaccine (p = 0.004). No relationship between pertussis immunization and the occurrence of central nervous system infections was noted.

Asunto(s)

Encefalopatías/etiología , Vacuna contra la Tos Ferina/efectos adversos , Factores de Edad , Toxoide Diftérico/efectos adversos , Vacuna contra Difteria, Tétanos y Tos Ferina , Combinación de Medicamentos/efectos adversos , Epilepsia/etiología , Humanos , Esquemas de Inmunización , Lactante , Meningitis/etiología , Meningoencefalitis/etiología , Estudios Retrospectivos , Convulsiones/etiología , Toxoide Tetánico/efectos adversos