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2.
Clin Nutr ; 35(4): 812-8, 2016 08.
Artículo en Inglés | MEDLINE | ID: mdl-26249791

RESUMEN

BACKGROUND & AIMS: Eating habits may influence the life span and the quality of ageing process by modulating inflammation. The RISTOMED project was developed to provide a personalized and balanced diet, enriched with or without nutraceutical compounds, to decrease and prevent inflammageing, oxidative stress and gut microbiota alteration in healthy elderly people. This paper focused on the effect on inflammation and metabolism markers after 56 days of RISTOMED diet alone or supplementation with three nutraceutical compounds. METHODS: A cohort of 125 healthy elderly subjects was recruited and randomized into 4 arms (Arm A, RISTOMED diet; Arm B, RISTOMED diet plus VSL#3 probiotic blend; Arm C, RISTOMED diet plus AISA d-Limonene; Arm D, RISTOMED diet plus Argan oil). Inflammatory and metabolism parameters as well as the ratio between Clostridium cluster IV and Bifidobacteria (CL/B) were collected before and after 56 days of dietary intervention, and their evolution compared among the arms. Moreover, participants were subdivided according to their baseline inflammatory parameters (erythrocytes sedimentation rate (ESR), C-Reactive Protein, fibrinogen, Tumor Necrosis Factor-alfa (TNF-α), and Interleukin 6) in two clusters with low or medium-high level of inflammation. The evolution of the measured parameters was then examined separately in each cluster. RESULTS: Overall, RISTOMED diet alone or with each nutraceutical supplementation significantly decreased ESR. RISTOMED diet supplemented with d-Limonene resulted in a decrease in fibrinogen, glucose, insulin levels and HOMA-IR. The most beneficial effects were observed in subjects with a medium-high inflammatory status who received RISTOMED diet with AISA d-Limonene supplementation. Moreover, RISTOMED diet associated with VSL#3 probiotic blend induced a decrease in the CL/B ratio. CONCLUSIONS: Overall, this study emphasizes the beneficial anti-inflammageing effect of RISTOMED diet supplemented with nutraceuticals to control the inflammatory status of elderly individuals.


Asunto(s)
Dieta , Suplementos Dietéticos , Inflamación/terapia , Anciano , Anciano de 80 o más Años , Biomarcadores/sangre , Glucemia/metabolismo , Índice de Masa Corporal , Proteína C-Reactiva/metabolismo , Análisis por Conglomerados , Ciclohexenos/administración & dosificación , Femenino , Fibrinógeno/metabolismo , Microbioma Gastrointestinal , Hemoglobina Glucada/metabolismo , Humanos , Insulina/sangre , Interleucina-6/sangre , Limoneno , Masculino , Estrés Oxidativo , Aceites de Plantas/administración & dosificación , Probióticos/administración & dosificación , Terpenos/administración & dosificación , Factor de Necrosis Tumoral alfa/sangre
3.
Thymus ; 21(1): 1-10, 1993 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-8480342

RESUMEN

This paper reviews the different series of thymectomies performed in patients with autoimmune diseases other than myasthenia gravis. It is possible that thymectomy can decrease the activity of T-helper lymphocytes or, alternatively, it may enhance the activity of T-suppressor lymphocytes, whose function is depressed in autoimmune diseases. Thymectomy was performed empirically for systemic lupus erythematosus and rheumatoid arthritis. The therapeutic benefits were questionable. Conflicting results were reported for thymectomy against autoimmune hemolytic anemia. Several trials were conducted to assess the therapeutic value of thymectomy in multiple sclerosis. Benefits were achieved only in relapsing-remitting but not in chronic-progressive multiple sclerosis. The effect of thymectomy in autoimmune diseases associated with myasthenia gravis were also reported. The authors conclude that thymectomy as treatment for autoimmune diseases other than myasthenia gravis is not elective therapeutic choice and it is acceptable only in selected cases.


Asunto(s)
Enfermedades Autoinmunes/cirugía , Timectomía , Anemia Hemolítica Autoinmune/cirugía , Animales , Artritis Reumatoide/cirugía , Enfermedades Autoinmunes/inmunología , Humanos , Lupus Eritematoso Sistémico/cirugía , Esclerosis Múltiple/cirugía , Miastenia Gravis/cirugía , Subgrupos de Linfocitos T/inmunología
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