RESUMEN
The mean platelet component (MPC) is a new platelet parameter generated by the Bayer ADVIA 120 full blood count analyser as part of the routine complete blood count (CBC) test cycle. We report a case of myelodysplasia with bleeding complications and abnormal template bleeding time in whom low mean platelet component parameters were associated with partial platelet granule deficiency, demonstrated by transmission electron microscopy. We suggest that the mean platelet component is an inexpensive and rapid test to screen for platelet dysfunction related to ultrastructural abnormalities in myelodysplasia.
Asunto(s)
Trastornos de las Plaquetas Sanguíneas/patología , Plaquetas/patología , Síndromes Mielodisplásicos/complicaciones , Pruebas de Función Plaquetaria/métodos , Trastornos de las Plaquetas Sanguíneas/diagnóstico , Plaquetas/ultraestructura , Femenino , Hemorragia/etiología , Hemorragia/patología , Humanos , Microscopía Electrónica , Persona de Mediana Edad , Síndromes Mielodisplásicos/sangre , Pruebas de Función Plaquetaria/instrumentaciónRESUMEN
One hundred and twenty-two samples from normal volunteers were processed for full blood count analysis through the Bayer ADVIA120. The samples were simultaneously tested using the marker CD62P to establish the absence of platelet activation. Samples were tested at two time intervals, 20 min and 3.5 h, to simulate the testing practice for routine and urgent samples in our laboratory. From these data the mean and reference ranges, with 95% confidence limits, for platelet parameters were calculated for the ADVIA120. The time difference for some platelet parameters was significant. Hence two ranges have been reported. The age or smoking habit of the volunteer did not significantly affect platelet results but there was a statistically significant sex difference in some platelet parameters.