RESUMEN

Subsets of murine CD4+ T cells localize to different areas of the spleen after adoptive transfer. Naïve and T helper 1 (TH1) cells, which express the chemokine receptor CCR7, are home to the periarteriolar lymphoid sheath, whereas activated TH2 cells, which lack CCR7, form rings at the periphery of the T cell zones near B cell follicles. Retroviral transduction of TH2 cells with CCR7 forces them to localize in a TH1-like pattern and inhibits their participation in B cell help in vivo but not in vitro. Thus, differential expression of chemokine receptors results in unique cellular migration patterns that are important for effective immune responses.

Asunto(s)

Linfocitos B/inmunología , Receptores de Quimiocina/inmunología , Bazo/inmunología , Células TH1/inmunología , Células Th2/inmunología , Traslado Adoptivo , Animales , Calcio/metabolismo , Movimiento Celular , Activación de Linfocitos , Ratones , Ratones Endogámicos BALB C , Ratones Transgénicos , Ovalbúmina/inmunología , Receptores CCR7 , Receptores de Quimiocina/metabolismo , Transducción de Señal , Células TH1/metabolismo , Células Th2/metabolismo , Transfección