RESUMEN

Our primary goal was to determine if leukocytes are a source of nerve growth factor (NGF) in mouse spleen. Noradrenergic nerves were localized to arteries and white pulp in normal spleens but only to arteries in ultra-immunodeficient R2G2 mice that lack leukocytes. NGF mRNA was detected in vascular cells and leukocytes of normal spleen, and several of the latter were T cells based on double labeling for NGF mRNA and CD3. Our findings indicate NGF is produced by vascular cells and to a lesser extent by leukocytes in spleen and provide support for pleiotropic actions in spleen and salivary glands.

Asunto(s)

Factor de Crecimiento Nervioso , Glándulas Salivales , Bazo , Animales , Ratones , Factor de Crecimiento Nervioso/metabolismo , ARN Mensajero/genética , Glándulas Salivales/metabolismo , Bazo/metabolismo , Linfocitos T/metabolismo