RESUMEN
In a passive auditory oddball study the development of novelty processing was examined in 5-7 (N=26), 8-9 (N=31), 10-12 (N=30), and 18-29 (N=35) years olds. Even though the main goal of this study was to replicate the findings of an earlier one, a shorter and simplified paradigm was used in order to gather developmental reference data for non-responsive patient groups that are unable to give an overt response. As expected, this adapted procedure replicated the findings regarding the development of passive novel sound processing. Firstly, the present data indicated two novelty components, each with a different topography and a different development. Secondly, both novelty components were still not mature in 10-12 years olds. The early novelty P3 had a central focus and its amplitude became more positive with increasing age. Also, its latency did not differ between the four age groups. The focus of the late novelty P3 shifted from frontocentral in 5-7 years olds to parietal in adults. In addition, the late novelty P3 amplitude at Pz became more positive with age, while the late novelty P3 latency was longer in 5-7 and 8-9 years olds compared to 10-12 years olds and adults. Thus, it appears that the adapted paradigm is a suitable tool for assessing auditory novelty processing in non-responsive patients.
Asunto(s)
Adaptación Fisiológica/fisiología , Corteza Auditiva/crecimiento & desarrollo , Corteza Auditiva/fisiología , Percepción Auditiva/fisiología , Potenciales Evocados Auditivos/fisiología , Estimulación Acústica , Adolescente , Adulto , Factores de Edad , Niño , Preescolar , Electroencefalografía , Potenciales Relacionados con Evento P300/fisiología , Femenino , Humanos , Masculino , Tiempo de Reacción/fisiología , Valores de ReferenciaRESUMEN
OBJECTIVE: The relative change in amplitude of the P50 component in response to the second click compared to the first one is commonly thought to index sensory gating. Despite numerous P50 gating studies, reports about its development are scarce. The present study examined the development and gender differences of P50 sensory gating. METHODS: A standard P50 paradigm was used to study sensory gating in adults (N=31) and in children aged 10-12 years (N=29), 8-9 years (N=26) and 5-7 years (N=26). RESULTS: The speed of processing and the frontocentral scalp distribution in P50 sensory gating are already mature at the age of 5 years. However, children of 5-7 years of age had smaller amplitudes to the first response and showed less sensory gating compared to the older age groups. No gender differences were found. CONCLUSIONS: Sensory gating matures around the age of 8 years. SIGNIFICANCE: The current data help in evaluating whether abnormal P50 sensory gating is due to maturational delay. There is no need to take into account gender differences.
Asunto(s)
Electroencefalografía , Potenciales Evocados Auditivos/fisiología , Estimulación Acústica , Adolescente , Adulto , Envejecimiento/fisiología , Niño , Preescolar , Electrooculografía , Femenino , Humanos , Masculino , Corteza Prefrontal/fisiología , Caracteres SexualesRESUMEN
Adults with Prader-Willi syndrome (PWS) and normal controls participated in a cognitive psychophysiology study in which event-related brain activity was recorded in a visual and auditory oddball task. In both tasks, participants were instructed to press a hand key to a target stimulus. All participants had successful task performance but persons with PWS had more target omissions than controls in the visual oddball task. The event-related brain activity in the PWS group revealed an abnormal deflation of the P3 component in both the visual and auditory oddball tasks. The findings support the notion that the auditory modality is more affected than the visual modality and of a short-term memory impairment in persons with PWS.