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Performance in a driving simulator was evaluated as a function of locus of control, perceived alcohol ingestion (no alcohol versus a no-alcohol placebo), and sex. Using a pretest-posttest design, an analysis of covariance was performed using the pretest performance on a driving simulator as the covariate. There were 10 men and 10 women in each of four groups. As predicted, the external-scoring placebo subjects made more posttest errors than did the internal-scoring placebo group or either of the no-alcohol control groups. This indicated that the external-scoring placebo subjects were more affected by what they expected to happen than their actual physiological state warranted. A difference was also found in which external-scoring women made more errors than did any other group. This was an unexpected finding which, being inconsistent with previous findings involving sex, warrants further research.

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To investigate the influence of locus of control on a fine motor corrdination task where subjects had ingested or believed that they had ingested alcohol, 60 men who were enrolled in introductory psychology and scored in the upper or lower thirds of the population on Rotter's I-E Scale (30 external and 30 internal scorers) were randomly assigned to one of three treatment conditions: a control group (no alcohol expected/no alcohol received), an alcohol group (alcohol expected/alcohol received), and a placebo group (alcohol expected/no alcohol received). Pretest and posttest measures of performance on the Purdue Pegboard Test were obtained from all subjects. Subjects in the control groups were given three 6-oz. (177.4-ml) glasses of fruit punch over a 35-min. waiting period between pretest and posttest on the Purdue Pegboard. The alcohol groups drank a sufficient number of similar glasses (usually three) to produce a 0.1% measure on a breathalyzer before completing the posttest on the Purdue. Pegboard. The placebo groups were told that they were drinking an alcohol-based drink but were served three glasses of a nonalcoholic, rum-flavored fruit drink. These groups were also told that they measured 0.1% on a breathalyzer. Control groups, both internal and external scorers, showed essentially no change from pre- to posttest on the Purdue Pegboard. The alcohol groups, on the other hand, both internal and external scorers, showed a significant decrement in performance. The internal-placebo group did not differ from the two control groups and showed no decrement in performance.(ABSTRACT TRUNCATED AT 250 WORDS)

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Preventive medicine could be the answer to many of the problems facing medicine, the author says. However, to be cost effective, we need to merge this new type of care with the traditional treatment of the sick that has been the foundation of health care for centuries.

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Two term neonates born within four days of each other at a small hospital developed sepsis and meningitis caused by a unique strain of Citrobacter diversus not previously reported to cause meningitis. Eleven (27.5%) of 40 other infants admitted to the nursery during the epidemic period developed rectal or umbilical colonization by C. diversus. Contact soon after birth with either of two nurses was more common among infected or colonized infants than among infants who were not infected or colonized. Hand cultures of both nurses and a rectal culture of one of the nurses yielded the epidemic strain. C. diversus may have been introduced into the nursery by the rectal carrier and spread person to person. Six weeks later continued surveillance identified a second cluster (of four colonized infants) associated with a mother who was a carrier of C. diversus and whose newborn infant became colonized at birth. The outbreak ended after strict control measures were used.

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As hospital restructuring becomes more frequent, therein lies an opportunity for pathologists to establish regional laboratories, either independently or as joint ventures with hospitals. The author discusses some of the pressures to unbundle, and steps that pathologists can take to meet this challenge.

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In this article, a pathologist with experience under New Jersey's diagnosis-related group system makes some predictions about the practice of pathology under the new reimbursement laws and regulations.

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Ten patients with thrombocytopenia (TTP) were treated recently in our institution with plasma exchange (PE), steroids, and antiplatelet drugs. Additionally, fresh frozen plasma (FFP) was administered to nine patients, with folic acid given to eight patients. After 13 to 25 months of follow-up, we found that four patients achieved and remained in remission after initial treatment. Three patients had four relapses, which developed while they were taking antiplatelet therapy, and which were treated successfully with FFP alone, or with PE in addition to FFP. Four patients suffered major neurological or renal damage during their presentation or initial treatment. One of these patients died during his initial hospitalization. Another patient died 7 months after initial treatment. After analyzing this experience, we have concluded that antiplatelet drugs or corticosteroid should be used as the sole initial treatment most cautiously. The relative importance of the exchange process, per se, versus plasma infusion cannot be inferred from our observations, but plasma exchange with FFP appears to have had a real impact on recovery.

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Listeria monocytogenes was isolated from both the blood and the synovial fluid of a diabetic patient with a septic arthritis involving the ankle.

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