RESUMEN

Molecular tweezers for lysine and arginine select a few residues on a protein surface and by their unique complexation mode disrupt a critical protein-protein interaction. Detailed structural information was gained by NMR experiments, strongly supported by QM/MM calculations and further substantiated by ITC, fluorescence anisotropy, ELISA and bio-layer-interference studies.

Asunto(s)

Proteínas/química , Arginina/química , Ensayo de Inmunoadsorción Enzimática , Polarización de Fluorescencia , Lisina/química , Espectroscopía de Resonancia Magnética , Modelos Moleculares , Conformación Molecular , Unión Proteica , Teoría Cuántica , Propiedades de Superficie