RESUMEN
We conducted a two-part study to determine whether any positive association between the use of allopurinol and the development of cataracts could be demonstrated. Study 1 included 251 Boston-area patients hospitalized for cataract and 753 matched controls. Two cataract patients were regular allopurinol users as compared with six control patients. The relative risk for cataract comparing allopurinol users with nonusers was 1.0 (95% exact confidence interval 0.14, 4.7). Study 2 included 389 patients from the Puget Sound, Washington, area who were hospitalized for cataract surgery during a five-year period (551,543 person-years). The rate of hospitalization for cataract in patients 30 to 49 years old was 0/992 person-years for allopurinol users and 78/366,960 (2.1 per 10(4)) person-years for nonusers. The rate of hospitalization for cataract in patients 50 to 64 years old was 3/2,270 (13.2 per 10(4)) person-years for allopurinol users and 308/184,583 (16.7 per 10(4)) person-years for nonusers.
Asunto(s)
Alopurinol/efectos adversos , Catarata/inducido químicamente , HumanosRESUMEN
Serologic evidence now confirms epidemiologic evidence that human immune serum globulin (ISG) protects susceptible patients from hepatitis A provided it is administered prior to exposure to the virus. In two wards of young patients housed at the Lynchburg (Virginia) Training School and Hospital for the mentally retarded, 44 out of 60 patients had no detectable antibody to hepatitis A prior to an epidemic which took place there in 1970; 12 of 19 non-immunized susceptible patients contracted the disease, while only four of 25 patients receiving ISG developed hepatitis. These four were probably infected with the virus prior to ISG administration. Of the 16 patients with pre-existing antibody, none showed any signs of symptoms of hepatitis.
Asunto(s)
Brotes de Enfermedades/prevención & control , Hepatitis A/prevención & control , Inmunoglobulinas/administración & dosificación , Anticuerpos Antivirales/análisis , Antígenos Virales/análisis , Hepatitis A/inmunología , HumanosRESUMEN
A traumatic phacocele in a previously injured eye is reported. Although subconjunctival dislocation of the lens is relatively rare, it should be considered in the differential diagnosis of an acquired, large conjunctival mass.