RESUMEN

OBJECTIVE: To test the hypothesis that 5,10-methylenetetrahydroreductase (MTHFR) polymorphisms can partially explain the individual variation in developing attention-deficit/hyperactivity disorder (ADHD) after acute lymphoblastic leukemia (ALL) therapy. STUDY DESIGN: Parents of 48 survivors of childhood ALL completed a clinical diagnostic process to identify subtypes of ADHD. Genotyping was performed with peripheral blood DNA for MTHFR (C677T and A1298C) polymorphisms. RESULTS: Eleven of the 48 patients (22.9%) had scores consistent with the inattentive symptoms of ADHD. Patients with genotypes related to lower folate levels (11 out of 39; 39.2%) were more likely to have ADHD. The A1298C genotype appeared to be the predominant linkage to the inattentive symptoms, leading to a 7.4-fold increase in diagnosis, compared with a 1.3-fold increase for the C677T genotype. Age at diagnosis and sex were not associated with inattentiveness. CONCLUSIONS: Preliminary data imply a strong relationship between MTHFR polymorphisms and the inattentive symptoms of ADHD in survivors of childhood ALL.

Asunto(s)

Trastorno por Déficit de Atención con Hiperactividad/genética , Metilenotetrahidrofolato Deshidrogenasa (NAD+)/genética , Polimorfismo Genético , Leucemia-Linfoma Linfoblástico de Células Precursoras , Adulto , Antimetabolitos Antineoplásicos/administración & dosificación , Antimetabolitos Antineoplásicos/efectos adversos , Trastorno por Déficit de Atención con Hiperactividad/enzimología , Niño , Femenino , Antagonistas del Ácido Fólico/administración & dosificación , Antagonistas del Ácido Fólico/efectos adversos , Predisposición Genética a la Enfermedad , Genotipo , Humanos , Masculino , Metotrexato/administración & dosificación , Metotrexato/efectos adversos , Metilenotetrahidrofolato Deshidrogenasa (NAD+)/efectos de los fármacos , Padres , Polimorfismo Genético/efectos de los fármacos , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Encuestas y Cuestionarios , Sobrevivientes