RESUMEN

Administration of hGH during the acute phase of experimental myocardial infarctions in pigs showed several aspects which clearly distinguished the treated group from the control one. In the first case the necrotic segment appeared considerably smaller than in the control group but also exhibit a qualitative different necrotic pattern in the histologic aspect, i.e. the infarcted area is shown itself reduced to isolated cells; scarce clusters of them interspersed where found within larger areas of preserved tissue. Affected cells have been defined as "injured fibres" according to their particular aspect which notably differs to the classic expected picture of a 25th day infarction and exhibits itself as an "arrested necrosis". A remarkable preservation of capillary vessels has also been found in the treated cases by a contrasting disappearance of the capillary bed in the control group. Ventricular contractility was also explored with ECHO B which showed significant differences between both groups: wall thinning of the ventricular wall in the affected area did not appear in treated cases and normal contractility in the same area reappeared a few hours after the infarction. Contractility was never restored in the control group. hGH main action is directed towards the preservation of the myocardial collagen matrix, helping to maintain the structural integrity of ventricular wall. There are, however, other possible effects on immunological aspects of the macrophages partially noticed, and to be disclosed in the future.

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We administered human growth hormone to a group of rats with experimental myocardial infarctions, in order to observe its action on the connective tissue repair process and the consequent effect on postinfarction ventricular aneurysms. Myocardial connective tissue displays a complex layout around each myocyte and among neighboring ones. It has been shown to be highly vulnerable to acute coronary ischemia which affects its diverse components in accordance with a precise timetable. The ultimate consequence of ischemia on connective tissue is the disappearance of intermyocytic links and the collagen weave that surrounds each cell. Damage to this collagen framework of the heart is responsible for the final disarray of myocytes, with a parallel effect to the myocytolytic actions of ischemia within the very structure of each cell. Hence, the appearance of postinfarction ventricular aneurysms seems to be related to failure in normal repair processes resulting from maturation of new collagen tissue into the area of myocardial necrosis. It has been shown that, besides the well-known actions on chondrocytes, hypothalamic-hypophyseal human growth hormone and somatomedins activate the fibroblasts. Administration of human growth hormone resulted in a significant decrease in the incidence of ventricular aneurysms. Scanning electron microscopy showed a good preservation of connective tissue components of myocardium. A different histological pattern of necrosis resulted in the treated group.

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A 24-year-old woman underwent an upper digestive hemorrhage. Endoscopy revealed a triple, elevated, submucosal lesion. One of them was ulcerated. A Billroth type I gastrectomy was performed. Post-operative course was uneventful and the patient remained asymptomatic for eighteen month. Histology revealed a monomorphous cellular proliferation, with a rosette-like pattern in some areas and trabecular in others. Histochemical methods confirmed the diagnosis. This one is an infrequent lesion; 0.02% of all gastric tumors. Some research studies have related this kind of tumors with prolonged ingestion of H2 inhibitors and others antacid. These tumors stem from Kultschitzky cells coming from the neuroectoderm. They are scarce in stomach; thus these tumors become infrequent. Effective treatment is endoscopy removal of pedunculated lesions or surgery for the bigger ones.

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RESUMEN

A 24-year-old woman underwent an upper digestive hemorrhage. Endoscopy revealed a triple, elevated, submucosal lesion. One of them was ulcerated. A Billroth type I gastrectomy was performed. Post-operative course was uneventful and the patient remained asymptomatic for eighteen month. Histology revealed a monomorphous cellular proliferation, with a rosette-like pattern in some areas and trabecular in others. Histochemical methods confirmed the diagnosis. This one is an infrequent lesion; 0.02

of all gastric tumors. Some research studies have related this kind of tumors with prolonged ingestion of H2 inhibitors and others antacid. These tumors stem from Kultschitzky cells coming from the neuroectoderm. They are scarce in stomach; thus these tumors become infrequent. Effective treatment is endoscopy removal of pedunculated lesions or surgery for the bigger ones.

RESUMEN

A 24-year-old woman underwent an upper digestive hemorrhage. Endoscopy revealed a triple, elevated, submucosal lesion. One of them was ulcerated. A Billroth type I gastrectomy was performed. Post-operative course was uneventful and the patient remained asymptomatic for eighteen month. Histology revealed a monomorphous cellular proliferation, with a rosette-like pattern in some areas and trabecular in others. Histochemical methods confirmed the diagnosis. This one is an infrequent lesion; 0.02

of all gastric tumors. Some research studies have related this kind of tumors with prolonged ingestion of H2 inhibitors and others antacid. These tumors stem from Kultschitzky cells coming from the neuroectoderm. They are scarce in stomach; thus these tumors become infrequent. Effective treatment is endoscopy removal of pedunculated lesions or surgery for the bigger ones.