RESUMEN
The influence of aging on serum levels of gonadotropins (FSH and LH), testosterone and estradiol was studied in the following groups: 4 normal men (ages 30 to 50), 38 men with symptoms of the male climacteric (ages 51 to 84), 25 men with relative impotence (ages 31 to 50), 10 normal women (ages 24 to 31), and 6 menopausal women (ages 58 to 76). FSH and LH levels began to rise in men in their 40's, and the increase became more conspicuous in the later age decades. The degree of elevation was nowhere comparable to that observed in the aging women. In the male, the serum testosterone levels showed a progressive decrease from the fifth age decade onward, whereas in the female there was an increase after the menopause. Estradiol levels showed no significant change in the aged male, but they were somewhat higher than in the aged female. Exceptions to the low-testosterone and low-gonadotropin relationship were observed in individual cases and might be explained by relatively high estradiol values. Proper replacement therapy by means of estrogens for the postmenopausal female and androgens for the aging male is often of great benefit, physically and emotionally.
Asunto(s)
Envejecimiento , Estradiol/sangre , Hormona Folículo Estimulante/sangre , Hormona Luteinizante/sangre , Testosterona/sangre , Adulto , Anciano , Andrógenos/uso terapéutico , Estrógenos/uso terapéutico , Femenino , Humanos , Masculino , Menopausia , Persona de Mediana EdadRESUMEN
PIP: Reported is a study of the effects of estradiol pellet implants, supplemented by administration of an oral progesterone for 3 to 5 days, on 120 women aged 15-39 years. Initial treatment involved 4 pellets of estradiol (25 mg each) implanted at 6-month intervals. Once inhibition of ovulation was established, the dosage was gradually reduced to 3, 2, and 1 pellet without decreased suppression of ovulation. 1 conception occurred during the entire series. There were a few complaints of breast tenderness during the first few months of treatment. Breakthrough bleeding was rare. The few cases of hypermenorrhea were corrected by extending the progesterone treatment from 3 to 5 to 7 days. No instances of amenorrhea-galactorrhea were reported. Spontaneous ovulation usually returned within 12 months of discontinuation of treatment.^ieng