RESUMEN
On the model of transplanted leukemia p-388, cytophotometry has shown that tumors' impact on the body includes two stages: direct affection of the target organ, indirect affection through changes in functional relations with cell populations of other organs due to the impact of transformed cells of the damaged target organ. Moreover, the progress of tumor growth alters functional relations between the organs.
Asunto(s)
Transformación Celular Neoplásica , Leucemia Experimental/patología , Leucemia Linfoide/patología , Animales , Médula Ósea/metabolismo , Médula Ósea/patología , Médula Ósea/fisiopatología , Línea Celular Tumoral , Riñón/metabolismo , Riñón/patología , Riñón/fisiopatología , Leucemia Experimental/genética , Leucemia Experimental/metabolismo , Leucemia Experimental/fisiopatología , Leucemia Linfoide/genética , Leucemia Linfoide/metabolismo , Leucemia Linfoide/fisiopatología , Hígado/metabolismo , Hígado/patología , Hígado/fisiopatología , Pulmón/metabolismo , Pulmón/patología , Pulmón/fisiopatología , Ratones , Ratones Endogámicos DBA , Trasplante de NeoplasiasRESUMEN
Any system transforms into a qualitatively new state if the number of its elements changes (increases or decreases in comparison with the standard checkpoint: norm, previous status of the system, etc.) by at least 1/3.
Asunto(s)
Asterias/fisiología , Neoplasias Colorrectales/patología , Embrión no Mamífero/fisiología , Neoplasias Glandulares y Epiteliales/patología , Animales , Asterias/embriología , Asterias/crecimiento & desarrollo , Blástula/fisiología , Carcinoma/genética , Carcinoma/patología , Transformación Celular Neoplásica , Neoplasias Colorrectales/genética , Gástrula/fisiología , Humanos , Pólipos Intestinales/genética , Pólipos Intestinales/patología , Larva/fisiología , Neoplasias Glandulares y Epiteliales/genéticaRESUMEN
Electron-microscopic examination of 5 cases with histological diagnosis of Manganotti's cheilitis was made. As distinct from other types of heilitis, disintegration of the basement membrane (up to its disappearance in some areas) and pronounced changes in the basement layer of the epithelium are characteristic for this type. Shedding of plasmalemms, a decrease of desmosomal complexes, appearance of microvilli were seen in the basal cells of the epithelium. A pronounced reaction of blood and connective tissue cells which invade basal and spinous layer of the epithelium was observed.