RESUMEN
Biocarbazin (5-3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide) when administered in different doses and schedules depressed the primary immune response of mice to erythrocytes (SE). A dose-dependent effect on the immunosuppression degree is revealed. Both the inductive and productive stages of antibody formation are sensitive to the immunosuppressive action of the agent. Under certain conditions biocarbazin induced a sharp suppression of humoral immune response. At the same time, it enhanced significantly the delayed-type hypersensitivity (DTH) response to SE.
Asunto(s)
Formación de Anticuerpos/efectos de los fármacos , Dacarbazina/farmacología , Inmunidad Celular/efectos de los fármacos , Animales , Formación de Anticuerpos/inmunología , Relación Dosis-Respuesta a Droga , Femenino , Hipersensibilidad Tardía/inducido químicamente , Hipersensibilidad Tardía/inmunología , Tolerancia Inmunológica/efectos de los fármacos , Tolerancia Inmunológica/inmunología , Inmunidad Celular/inmunología , Inmunización , Tejido Linfoide/efectos de los fármacos , Tejido Linfoide/inmunología , Ratones , Ratones Endogámicos BALB C , Tamaño de los Órganos/efectos de los fármacos , Tamaño de los Órganos/inmunología , Formación de Roseta , Factores de TiempoRESUMEN
The growth characteristics and the effect of clinically available chemotherapeutic agents on two transplantable colon tumor lines were studied. These are subcutaneously transplanted undifferentiated carcinoma AKATOL, originating from tumors "spontaneously" appearing after foetal colon implantation, and moderately differntiated carcinoma No. 173 obtained likewise with additional treatment by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Some basic kinetic parameters of tumor growth are determined. The tumors show a relatively slow growth, the median survival time of animals being approximately 50 and 38 days, respectively. The investigation of the sensitivity of tumor lines shows that they are sensitive to many standard antitumor drugs. In the case of AKATOL a high responsiveness to antibiotics and to a smaller degree to other groups agents was observed excluding sarcolysine, CCNU, alexan (cytosine arabinoside) and vinblastine. In the case of colon tumor No. 173 strong antitumor effect for CCNU, 5-fluorouracil, cyclophosphamide, methotrexate and vinblastine was observed. The possibilities to use these tumor systems for screening and evaluation of antitumor agents are discussed.