RESUMEN
Lung cancer is one of the leading causes of death worldwide. Pulmonary nodules located in the vicinity of the mediastinum, retrocardiac, near the aorta or pulmonary vessels, and in front of the spine, may be difficult to access through a percutaneous or bronchoscopic approach. Fine needle aspiration/biopsy guided by transesophageal echoendoscopy (EUS-FNA/FNB) is a minimally invasive method with low morbidity that could allow access to lesions in these places. We present the case of a patient with a solitary pulmonary nodule, in which the diagnosis of lung cancer was obtained by EUS-FNA/FNB.
El cáncer de pulmón es la principal causa de muerte por cáncer en todo el mundo. Los nódulos pulmonares ubicados en proximidad al mediastino, retrocardíacos, cercanos a grandes vasos o por delante de la columna vertebral pueden resultar de difícil acceso por vía percutánea o broncoscópica. La punción aspiración/biopsia con aguja fina guiada por ecoendoscopía transesofágica (EUS-FNA/FNB) es un método mini invasivo con baja morbilidad que permitiría acceder a estas localizaciones. Presentamos el caso de un paciente con nódulo pulmonar solitario, en el que se obtuvo el diagnóstico de cáncer de pulmón mediante EUS-FNA/FNB.
Asunto(s)
Carcinoma de Células Escamosas/patología , Biopsia por Aspiración con Aguja Fina Guiada por Ultrasonido Endoscópico/métodos , Neoplasias Pulmonares/patología , Anciano de 80 o más Años , Biopsia con Aguja Fina , Carcinoma de Células Escamosas/radioterapia , Endosonografía , Humanos , Neoplasias Pulmonares/radioterapia , Masculino , Tomografía Computarizada por Rayos XRESUMEN
El cáncer de pulmón es la principal causa de muerte por cáncer en todo el mundo. Los nódulos pulmonares ubicados en proximidad al mediastino, retrocardíacos, cercanos a grandes vasos o por delante de la columna vertebral pueden resultar de difícil acceso por vía percutánea o broncoscópica. La punción aspiración/biopsia con aguja fina guiada por ecoendoscopía transesofágica (EUS-FNA/FNB) es un método mini invasivo con baja morbilidad que permitiría acceder a estas localizaciones. Presentamos el caso de un paciente con nódulo pulmonar solitario, en el que se obtuvo el diagnóstico de cáncer de pulmón mediante EUS-FNA/FNB.
Lung cancer is one of the leading causes of death worldwide. Pulmonary nodules located in the vicinity of the mediastinum, retrocardiac, near the aorta or pulmonary vessels, and in front of the spine, may be difficult to access through a percutaneous or bronchoscopic approach. Fine needle aspiration/biopsy guided by transesophageal echoendoscopy (EUS-FNA/FNB) is a minimally invasive method with low morbidity that could allow access to lesions in these places. We present the case of a patient with a solitary pulmonary nodule, in which the diagnosis of lung cancer was obtained by EUS-FNA/FNB.
Asunto(s)
Humanos , Masculino , Anciano de 80 o más Años , Carcinoma de Células Escamosas/patología , Biopsia por Aspiración con Aguja Fina Guiada por Ultrasonido Endoscópico/métodos , Neoplasias Pulmonares/patología , Carcinoma de Células Escamosas/radioterapia , Tomografía Computarizada por Rayos X , Endosonografía , Biopsia con Aguja Fina , Neoplasias Pulmonares/radioterapiaRESUMEN
OBJECTIVES: The risk of developing metachronous advanced neoplastic lesions (ANLs) during surveillance after resection of sessile serrated adenomas (SSAs) has not been quantified. METHODS: Patients with sporadic SSAs resected between 1 April 2007 and 31 December 2009 who underwent surveillance colonoscopy in our institution were prospectively evaluated. Patients with low-risk adenomas (LRAs), high-risk adenomas (HRAs), and negative index colonoscopy (NIC) during the same period were identified using the pathology database and electronic medical records, and were also included as a comparison cohort. The primary outcome was the comparison of the study groups with regard to incidence of metachronous ANLs during surveillance colonoscopy. RESULTS: A total of 185 patients had SSAs, of whom 75 with 101 resected polyps were finally included. The comparison cohort consisted of 564 patients: 140 LRAs (160 polyps), 87 HRAs (478 polyps), and 337 NICs. The overall mean colonoscopy follow-up was for 54.5 months (±s.d. 14). SSA patients with synchronous HRA on index colonoscopy presented a higher incidence rate of metachronous ANL (12.96 per 1,000 person-months) compared with patients with HRA (5.07 per 1,000 person-months), whereas those with synchronous LRA and without synchronous adenoma on index colonoscopy presented a low incidence rate of metachronous ANL (0 and 1.41 per 1,000 person-months, respectively) similar to LRA (1.47 per 1,000 person-months). Among patients with SSA the 3- and 5-year ANL free-cumulative probability was 64.3 and 32.1% in those with synchronous HRA, 100 and 100% in those with synchronous LRA, and 95.1 and 91.7% if no synchronous adenoma was found. CONCLUSIONS: Among patients with resected sporadic SSAs the risk of developing metachronous ANL is influenced by the presence of synchronous HRA on index colonoscopy. Patients with SSAs and synchronous HRA on index colonoscopy require closer surveillance, whereas those with synchronous LRA and those without synchronous adenomas may be followed up in the same way as those with LRAs.
Asunto(s)
Adenoma/patología , Neoplasias del Colon/patología , Pólipos del Colon/patología , Neoplasias Primarias Secundarias/patología , Adenoma/epidemiología , Adenoma/cirugía , Anciano , Argentina/epidemiología , Neoplasias del Colon/epidemiología , Pólipos del Colon/epidemiología , Pólipos del Colon/cirugía , Colonoscopía , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Neoplasias Primarias Secundarias/epidemiología , Vigilancia de la Población , RiesgoRESUMEN
El cáncer colorrectal representa una de las primeras causas de muerte por cáncer en todo el mundo y también en la Argentina. En los últimos años la pesquisa de cáncer de colon ha cobrado gran importancia y se ha postulado a la colonoscopia como el patrón de oro. En esta revisión resumimos las evidencias de este método poniendolo en contexto con las complicaciones y desventajas.
Colorectal cancer is one of the leading causes of cancer deathworldwide and also in Argentina. In the past few years colorectalcancer screening has become more popular and colonoscopyhas been postulated as the gold standard. In thisreview we analyzed the evidence supporting this methodin contrast with its complications and disadvantages.
Asunto(s)
Neoplasias Colorrectales , Investigación , Adenocarcinoma , Colon , Colonoscopía , Neoplasias , PóliposRESUMEN
Colorectal cancer is one of the leading causes of cancer death worldwide and also in Argentina. In the past few years colorectal cancer screening has become more popular and colonoscopy has been postulated as the gold standard. In this review we analyzed the evidence supporting this method in contrast with its complications and disadvantages.
Asunto(s)
Pólipos Adenomatosos/diagnóstico , Colonoscopía , Neoplasias Colorrectales/diagnóstico , Pólipos Adenomatosos/epidemiología , Argentina/epidemiología , Colonoscopía/efectos adversos , Colonoscopía/normas , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/prevención & control , Progresión de la Enfermedad , Detección Precoz del Cáncer , Humanos , Factores de Riesgo , SigmoidoscopíaRESUMEN
El cáncer colorrectal representa una de las primeras causas de muerte por cáncer en todo el mundo y también en la Argentina. En los últimos años la pesquisa de cáncer de colon ha cobrado gran importancia y se ha postulado a la colonoscopia como el patrón de oro. En esta revisión resumimos las evidencias de este método poniendolo en contexto con las complicaciones y desventajas.
Colorectal cancer is one of the leading causes of cancer death worldwide and also in Argentina. In the past few years colorectal cancer screening has become more popular and colonoscopy has been postulated as the gold standard. In this review we analyzed the evidence supporting this method in contrast with its complications and disadvantages.
Asunto(s)
Humanos , Pólipos Adenomatosos/diagnóstico , Colonoscopía , Neoplasias Colorrectales/diagnóstico , Pólipos Adenomatosos/epidemiología , Argentina/epidemiología , Colonoscopía/efectos adversos , Colonoscopía/normas , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/prevención & control , Progresión de la Enfermedad , Detección Precoz del Cáncer , Factores de Riesgo , SigmoidoscopíaRESUMEN
El cáncer colorrectal representa una de las primeras causas de muerte por cáncer en todo el mundo y también en la Argentina. En los últimos años la pesquisa de cáncer de colon ha cobrado gran importancia y se ha postulado a la colonoscopia como el patrón de oro. En esta revisión resumimos las evidencias de este método poniendolo en contexto con las complicaciones y desventajas.(AU)
Colorectal cancer is one of the leading causes of cancer death worldwide and also in Argentina. In the past few years colorectal cancer screening has become more popular and colonoscopy has been postulated as the gold standard. In this review we analyzed the evidence supporting this method in contrast with its complications and disadvantages.(AU)
Asunto(s)
Humanos , Pólipos Adenomatosos/diagnóstico , Colonoscopía , Neoplasias Colorrectales/diagnóstico , Pólipos Adenomatosos/epidemiología , Argentina/epidemiología , Colonoscopía/efectos adversos , Colonoscopía/normas , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/prevención & control , Progresión de la Enfermedad , Detección Precoz del Cáncer , Factores de Riesgo , SigmoidoscopíaRESUMEN
AIM: To compare the efficacy of different doses of sodium phosphate (NaP) and polyethylenglicol (PEG) alone or with bisacodyl for colonic cleansing in constipated and non-constipated patients. METHODS: Three hundred and forty-nine patients, older than 18 years old, with low risk for renal damage and who were scheduled for outpatient colonoscopy were randomized to receive one of the following preparations (prep): 90 mL of NaP (prep 1); 45 mL of NaP + 20 mg of bisacodyl (prep 2); 4 L of PEG (prep 3) or 2 L of PEG + 20 mg of bisacodyl (prep 4). Randomization was stratified by constipation. Patients, endoscopists, endoscopists' assistants and data analysts were blinded. A blinding challenge was performed to endoscopist in order to reassure blinding. The primary outcome was the efficacy of colonic cleansing using a previous reported scale. Secondary outcomes were tolerability, compliance, side effects, endoscopist perception about the necessity to repeat the study due to an inadequate colonic preparation and patient overall perceptions. RESULTS: Information about the primary outcome was obtained from 324 patients (93%). There were no significant differences regarding the preparation quality among different groups in the overall analysis. Compliance was higher in the NaP preparations being even higher in half-dose with bisacodyl: 94% (prep 1), 100% (prep 2), 81% (prep 3) and 87% (prep 4) (2 vs 1, 3 and 4, P < 0.01; 1 vs 3, 4, P < 0.05). The combination of bisacodyl with NaP was associated with insomnia (P = 0.04). In non-constipated patients the preparation quality was also similar between different groups, but endoscopist appraisal about the need to repeat the study was more frequent in the half-dose PEG plus bisacodyl than in whole dose NaP preparation: 11% (prep 4) vs 2% (prep 1) (P < 0.05). Compliance in this group was also higher with the NaP preparations: 95% (prep 1), 100% (prep 2) vs 80% (prep 3) (P < 0.05). Bisacodyl was associated with abdominal pain: 13% (prep 1), 31% (prep 2), 21% (prep 3) and 29% (prep 4), (2, 4 vs 1, 2, P < 0.05). In constipated patients the combination of NaP plus bisacodyl presented higher rates of satisfactory colonic cleansing than whole those PEG: 95% (prep 2) vs 66% (prep 3) (P = 0.03). Preparations containing bisacodyl were not associated with adverse effects in constipated patients. CONCLUSION: In non-constipated patients, compliance is higher with NaP preparations, and bisacodyl is related to adverse effects. In constipated patients NaP plus bisacodyl is the most effective preparation.
Asunto(s)
Bisacodilo/administración & dosificación , Catárticos/administración & dosificación , Colonoscopía , Estreñimiento/tratamiento farmacológico , Defecación/efectos de los fármacos , Fosfatos/administración & dosificación , Polietilenglicoles/administración & dosificación , Irrigación Terapéutica/métodos , Anciano , Atención Ambulatoria , Argentina , Bisacodilo/efectos adversos , Catárticos/efectos adversos , Distribución de Chi-Cuadrado , Estreñimiento/fisiopatología , Método Doble Ciego , Femenino , Humanos , Masculino , Cumplimiento de la Medicación , Persona de Mediana Edad , Fosfatos/efectos adversos , Polietilenglicoles/efectos adversos , Irrigación Terapéutica/efectos adversos , Resultado del TratamientoRESUMEN
AIM: To assess the risk of colonic polyps, adenomas and advanced neoplastic lesions (ANL) in patients with sporadic gastric polyps, especially those with fundic gland polyps (FGP). METHODS: Clinical records of patients who had performed an upper and a lower digestive endoscopy between September 2007 and August 2008 were retrospectively analyzed. A case-control study was carried out, calling patients with gastric polyps as "cases" and patients without gastric polyps as "controls". The risk of colonic polyps, adenomas and ANL (villous component ≥ 25%, size ≥ 10 mm, or high grade dysplasia) was assessed [odds ratio (OR) and its corresponding 95%CI]. RESULTS: Two hundred and forty seven patients were analyzed: 78 with gastric polyps (cases) and 169 without gastric polyps (controls). Among the cases, the majority of gastric polyps were FGP (80%, CI: 69-88) and hyperplastic (20%, CI: 12-31); 25% had colonic polyps (25% hyperplastic and 68% adenomas, from which 45% were ANL). Among the controls, 20% had colonic polyps (31% hyperplastic and 63% adenomas, from which 41% were ANL). The patients with sporadic FGP had an OR of 1.56 (CI: 0.80-3.04) for colonic polyps, an OR of 1.78 (CI: 0.82-3.84) for colonic adenomas, and an OR of 0.80 (CI: 0.21-2.98) for ANL. Similar results were found in patients with gastric polyps in general. CONCLUSION: The results of this study did not show more risk of colorectal adenomas or ANL neither in patients with sporadic gastric polyps nor in those with FGP.
RESUMEN
Colorectal cancer is one of the leading causes of cancer death worldwide and also in Argentina. In the past few years colorectal cancer screening has become more popular and colonoscopy has been postulated as the gold standard. In this review we analyzed the evidence supporting this method in contrast with its complications and disadvantages.
Asunto(s)
Pólipos Adenomatosos/diagnóstico , Colonoscopía , Neoplasias Colorrectales/diagnóstico , Pólipos Adenomatosos/epidemiología , Argentina/epidemiología , Colonoscopía/efectos adversos , Colonoscopía/normas , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/prevención & control , Progresión de la Enfermedad , Detección Precoz del Cáncer , Humanos , Factores de Riesgo , SigmoidoscopíaRESUMEN
BACKGROUND: Although small bowel and esophagus neoplasia are recognized to occur more frequently in patients with celiac disease, the association with colorectal cancer is still controversial. OBJECTIVE: To determine the risk of colorectal neoplasia among patients with celiac disease. METHODS: A case-control study was conducted using the gastroenterology and endoscopy unit electronic data base. Patients with celiac disease and colonoscopy were regarded as cases and those without celiac disease and colonoscopy as controls. Patients were matched for age, sex, colonoscopy purpose and family history of colorectal cancer. The main outcome was the risk of colorectal polyps, adenomas, advanced lesions and cancer. The risk was expressed as odds ratio (OR) with the respective 95% confidence intervals (95% CI). RESULTS: Out of 178 celiac disease patients, 44 were included as cases. Eighty-eight non-celiac patients were included as controls. In cases, the presence of polyps, adenomas and advanced colonic lesions was 20%, 16% and 4.5%, respectively. In controls, it was 15%, 9% and3.4%, respectively. The risk of polyps, adenomas and advanced colonic lesions was similar in both groups: OR 1.48 (95% CI 0.59-3.73), OR 1.89 (95% CI 0.66-5.42) and OR 1.34 (95% CI 0.26-7.05). No colorectal cancer was identified. CONCLUSION: The risk of colorectal neoplasia within this cohort of patients with celiac disease was similar to the control population.
Asunto(s)
Enfermedad Celíaca/complicaciones , Pólipos del Colon/etiología , Neoplasias Colorrectales/etiología , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Colonoscopía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de RiesgoRESUMEN
OBJECTIVE: To determine the prevalence of serrated adenomas (SA), the frequency of high grade dysplasia (HGD) and adenocarcinoma in these polyps, and the association with synchronic (SNL) and metachronic neoplastic lesions (MNL). METHODS: Reports from patients undergoing colonoscopy and polypectomy from January 2003 to April 2010, were obtained from our electronic database. SA were reanalyzed by two pathologists and classified on the basis of Snover's diagnostic criteria. The prevalence of these polyps and the clinical and endoscopic features were determined. SNL were defined by adenomas, cancer or advanced neoplastic lesions (ANL) (> 1 cm, HGD and/or >75% of villous component) in the same colonoscopy. MNL were identified in patients who underwent surveillance colonoscopies. An univariate and multivariate analysis was performed, looking for independent predictors of HGD/ cancer, SNL and MNL in patients with SA. RESULTS: The prevalence of SA was 0.87%. The mean age was 60 years old and 50.5% of patients were women. Most of the polyps were sessile (67%), small (63%) and located in ceco-ascending colon (47%). We found HGD in 4.4% ofSA and no adenocarcinoma. SNL was found in 31% ofpatients: 46% adenomas, 40.5% ANL and 13.5% adenocarcinoma. MNL was found in 29% of patients: 25% SA, 31% adenomas, 44% ANL and 0% adenocarcinoma. Age over 60 years old was significantly associated with MNL [Odds ratio 3.7 (95% confidence interval 1.16-11.8)] and polyp's size higher than 1 cm with sessile SA histology [Odds ratio 8 (95% confidence interval 1.28-49.4)]. CONCLUSION: The prevalence of SA was low. We found an association with neoplastic lesions. Therefore, it is important to establish specific guidelines for the management of these polyps.
Asunto(s)
Adenoma/epidemiología , Neoplasias del Colon/epidemiología , Pólipos del Colon/epidemiología , Adenoma/patología , Adulto , Anciano , Anciano de 80 o más Años , Análisis de Varianza , Argentina/epidemiología , Neoplasias del Colon/patología , Pólipos del Colon/patología , Colonoscopía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Estudios RetrospectivosRESUMEN
BACKGROUND: Ménétrier's disease is a rare disease of the stomach generally described as hypertrophic gastropathy. Its etiology is unknown and its malignant potential is controversial. Only a few reports supporting its association with gastric cancer have been found. We present a case of gastric cancer associated with Ménétrier's disease. CASE REPORT: We present a 72 year-old-male with epigastric pain and early satiety during the last 5 months. He had been treated with proton pump inhibitors with unfavorable response and began with loss of weight and asthenia. An upper digestive endoscopy showed an erythematous nodular gastric mucosa, with enlarged folds. An abdominal CT scan demonstrated a circumferential parietal thickening of the gastric wall and adenopathies. A gastric macrobiopsy done by endoscopic mucosal resection evidenced a mucin infiltrating adenocarcinoma with invasion of the lamina propria. Subtotal gastrectomy was done. The histology showed a stomach with changes compatible with Ménétrier's disease and diffuse infiltration by a highly undifferentiated adenocarcinoma (plastic linitis). CONCLUSION: A patient with diffuse gastric adenocarcinoma and Ménétrier's disease is reported.
Asunto(s)
Adenocarcinoma Mucinoso/complicaciones , Gastritis Hipertrófica/complicaciones , Neoplasias Gástricas/complicaciones , Adenocarcinoma Mucinoso/diagnóstico , Anciano , Gastritis Hipertrófica/diagnóstico , Gastroscopía , Humanos , Masculino , Neoplasias Gástricas/diagnóstico , Tomografía Computarizada por Rayos XRESUMEN
OBJECTIVE: To determine de incidence of colonic polyps in colonoscopies performed before scheduled and to identifY the clinical and endoscopic features that predicted this finding. METHODS: All patients who underwent at least two complete colonoscopies less than three years apart were retrospectively identified in our computerized database. We excluded patients with high risk of colonic neoplasm requiring a new colonoscopy in less than three years. We analyzed the incidence of polyps before the first and third year after the first study, and the clinical and endoscopic features related to this finding by means of multivariate logistic regression. RESULTS: 378 paired colonoscopies fulfilled criteria, 129 were performed less than one year apart (group 1), and 249 less than three years apart (group 2). Regarding surveillance colonoscopies, 19% of patients presented adenomas and 1.5% high grade dysplasia (HGD) in group 1, and 21% presented adenomas and 2% HGD in group 2. In group 1 fair preparation (P = 0.03), and prolonged colonoscopy (P = 0.02) on the first study were independent predictors to find any polyp on the second study before scheduled. In group 2 fair cleansing (P = 0.04), history of sessile polyps (P = 0.01) and 3 or more polyps in the first study (P = 0.01) were independent predictors to find any polyp, while more than 5 polyps in the first study predicate adenomas. CONCLUSION: During the first year incident polyps related to difficult procedures (missed polyps?) while at 3 years the history of previous polyps was also important.
Asunto(s)
Neoplasias del Colon/diagnóstico , Pólipos del Colon/diagnóstico , Colonoscopía , Humanos , Modelos Logísticos , Persona de Mediana Edad , Análisis Multivariante , Vigilancia de la Población , Lesiones Precancerosas/diagnóstico , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Factores de TiempoRESUMEN
INTRODUCTION: The celiac disease (CD) is characterized by a permanent sensitivity to gluten. The treatment for this disease is the life-long strict compliance with a gluten-free diet (GFD). The average of compliance with GFD ranges between 15% and 80%. Antibodies' role in the follow up of these patients regarding the adherence to the GFD is not well established. Objective. To determine the relationship between the antibodies for CD and the adherence to the GFD in patients with over a year of treatment. MATERIAL AND METHODS: Patients with CD with a minimum of one year of GFD were prospectively included They were asked to complete a self-survey regarding to the compliance to GFD and the level of adherence was determined: low (no compliance or more than 2 gluten intakes per week), medium (1 or 2 gluten intakes per week or 2 or 3 gluten intakes per month), or high (1 gluten intake per month or less than 3 intakes per year). The follow up was performed by their general practitioners. From one year of GFD onwards, the results of the available antibodies at the time of the last follow up were assessed: antigliadine IgA (AGA) and IgG (AGG), anti-endomysium IgA (EMA) and IgG (EMG), anti-transglutaminase (ATG), and deaminated peptides of gliadine IgA and IgG, considering them as positive or negative. Through an univariate analysis, the above-mentioned antibodies were correlated (independent variables) in order to identify predicting factors of high and low adherence to the GFD (dependent variables). RESULTS: Ninety patients were analyzed, age 43.6 +/- 15.3 years old, 89% women, 58% classic celiacs. The average time of GFD was 7.9 years and 63% had been on a GFD for over 3 years. A 71% of patients (95% CI 69%-80%) showed high adherence to the GFD, and a 67% (95% CI 2%-13%) showed low adherence. GFD of less than 3 years was a determining factor for low adherence [relative risk (RR) 2.41 (95% CI 1.2-2.89)]. The predictive antibodies for GFD high adherence were: (1) negative EMA [RR 1.27 (95% CI 1.03-1.54)], (2) negative ATG [RR 1.62 (95% CI 1.12-2.47)], and (3) all negative requested ones [RR 1.60 (95% CI 1.17-2.18)]. The predictive antibodies for GFD low adherence were: (1) positive AGA [RR 15.5 (95% CI 2.29-105)], (2) positive EMA [RR 10.2 (95% CI 2.19-47.7)], (3) positive ATG [RR 9.63 (95% CI 1.53-63.4)], and 4) all negative requested ones [RR 0.11 (95% CI 0.018-0.71)]. CONCLUSION: After one year of treatment, the negativity of EMA or ATG antibodies had a significant correlation with the high adherence to GFD and the positivity of AGA, EMA or ATG antibodies had a significant correlation with a low adherence.
Asunto(s)
Autoanticuerpos/sangre , Enfermedad Celíaca/inmunología , Dieta Sin Gluten , Cooperación del Paciente/estadística & datos numéricos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Autoanticuerpos/inmunología , Enfermedad Celíaca/dietoterapia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Prospectivos , Encuestas y Cuestionarios , Factores de Tiempo , Adulto JovenRESUMEN
BACKGROUND AND AIMS: The endoscopic aspect of the colorectal mucosa in those patients with collagenous colitis is usually normal, or with non-specific changes. Until now it had never been related to a mucosal pattern of mosaic type. Our aim was to determine the diagnostic accuracy of the presence of mosaic pattern in the colorectal mucosa for collagenous colitis. METHODS: Patients who had undergone a colonoscopy with random biopsies performed in the diagnostic evaluation of chronic diarrhea between 2004 and 2008 were studied. We defined patients with chronic diarrhea and mosaic mucosal pattern as "cases", and patients with chronic diarrhea without mosaic pattern as "controls". The odds ratio (OR) of finding a collagenous colitis in view of a mosaic pattern in colon was determined; as well as sensitivity and specificity; positive and negative likelihood ratios (LR+, LR-), considering this finding as a diagnostic instrument for collagenous colitis. RESULTS: 252 patients who had undergone colonoscopy with biopsy due to chronic diarrhea were analyzed. In 6 patients, a mosaic pattern was identified in the colorectal mucosa. The histological diagnose of 36 of the 252 patients (14%) was microscopic colitis, 27 of which (11%) had collagenous colitis. The colonoscopy was found normal in 21 of these 27 patients; in 2 patients, congestion or petechiae was found in the rectum; and in 4 patients (15%), all women, a mosaic pattern was found in the rectosigmoid mucosa. The OR of this finding was 19.4 (CI 95% 3.9-95.4) for collagenous colitis. It had a sensitivity of 14.8% (CI 95% 6.8-20), a specificity of 99.1% (CI 95% 98.2-99.7), LR+ of 16.6 (CI 95% 3.7-76.4), and LR- of 0.86 (CI 95% 0.80-0.95) for a collagenous colitis. CONCLUSION: The mosaic pattern in the colorectal mucosa of patients studied due to chronic diarrhea could be a distinguishing feature of collagenous colitis.
Asunto(s)
Colitis Colagenosa/patología , Colon/patología , Colonoscopía , Mucosa Intestinal/patología , Recto/patología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Biopsia , Estudios de Casos y Controles , Niño , Colitis Linfocítica/patología , Diagnóstico Diferencial , Femenino , Humanos , Funciones de Verosimilitud , Masculino , Persona de Mediana Edad , Oportunidad Relativa , Estudios Retrospectivos , Sensibilidad y Especificidad , Adulto JovenRESUMEN
Antecedentes: La detección de lesiones preneoplásicas y del cáncer colorrectal a través de distintos estudios es efectiva para la prevención y el tratamiento de la enfermedad. Objetivo: Evaluar los resultados obtenidos con videocolonoscopías efectuadas a pacientes asintomáticos, sin riesgo de enfermedad neoplásica colorrectal. Diseño: Estudio retrospectivo. Población: Pacientes sometidos a videocolonoscopías, cuyo motivo de estudio fue pesquisa. Método: Se analizaron características demográficas, tipo y localización de los hallazgos patológicos. Resultados: De 1788 videocolonoscopías realizadas entre Marzo de 2005 y Marzo de 2006. 214 (12 %) fueron por pesquisa. 115 (54 %) pacientes fueron hombres y 99 (46 por ciento) mujeres, con una edad promedio de 59.6 (50-79) años. El estudio fue completo en el 96,7 por ciento. En 71 (33 %) estudios se halló patología. En el 60 por ciento de éstos se encontraron pólipos. La prevalencia de pólipos en esta población fue del 20 por ciento y de cáncer colorrectal del 1,4 %. Se hallaron 59 pólipos en 43 pacientes. 42,4 % fueron hiperplásicos, 52.5 por ciento adenomatosos y el 5,1 % cánceres. El 76.3 % de los pólipos se localizaron en colon izquierdo y recto y el 23,7 % en colon derecho. De los 31 pólipos adenomatosos, 7 (22,6 %) se hallaron en colon derecho (3 con displasia) y 24 (77.4 %) en el izquierdo (19 con diplasia). Los 3 cánceres se localizaron en el colon derecho. 7/59 pólipos midieron más de 10 mm, 5 en rectosigma (adenomatosos con displasía) y 2 en colon derecho (cánceres). No hubo complicaciones ni mortalidad asociadas al método. Conclusión: La videocolonoscopía es eficaz como método de pesquisa en una población cerrada.
Background: Colonoscopy is considered the most effective screening tool for detecting premalignant lesions and early colorectal cancer (CRC). Aim: To evaluate the results with colonoscopy for colorectal cancer screening in average risk patients. Design: Retrospective study. Patients and Methods: All patients that underwent colonoscopy for screening were included. Screening was defined as colonoscopic examination in asymptomatic patients, older than 50 years, within family history of CRC and within history of colon diseases. Demographic characteristics, type and location of pathological findings were analyzed. Results: From 1788 colonoscopies achieved between March 2005 and March 2006, 214 (12 %) were for screening. The mean age of the patients was 59,6 (50-79) years, and 54 % (115) were men. Colonoscopy to the level of the cecum was completed in 96,7 % of the patients. 71 (33 %) procedures showed some pathological finding. 60 per cent of them were polyps, 33per cent diverticular disease and other things in 7 per cent. The prevalence of polyps was 20 %, adenomas 11,2 % and CRC 1.4 %. We found 59 polyps in 43 patients, 76,3 % in the left colon, 31 were adenomas, 25 hyperplastic polyps and 3 CRC. 7 (22,6 %) of 31 adenomas were found in the proximal colon. And all (3) CRC were situated in the right colon. 7/59 polyps had a diameter of at least 10 mm, five of them were adenomas with some grade of dysplasia and two CRC. There were no morbidity and mortality associated with this procedure. Conclusion: Colonoscopy is an effective tool for colorectal cancel' screening in a Community Hospital.
Asunto(s)
Humanos , Masculino , Femenino , Colonografía Tomográfica Computarizada/métodos , Colonoscopía/métodos , Neoplasias Colorrectales/diagnóstico , Diagnóstico por Imagen , Lesiones Precancerosas/diagnóstico , Lesiones Precancerosas/terapia , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/prevención & control , Prevalencia , Pólipos Intestinales/complicaciones , Pólipos Intestinales/epidemiologíaRESUMEN
El síndrome de Sweet o dermatosis neutrofílica aguda febril se caracteriza por presentar fiebre, placas eritematosas dolorosas, neutrofilia y un infiltrado dérmico constituido por neutrófilos con edema papilar y sin vasculitis. El compromiso cutáneo de la enfermedad inflamatoria intestinal es habitual, sin embargo la asociación con este síndrome es infrecuente.