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Squeaking has been reported after ceramic-on-ceramic total hip arthroplasty (THA), but its pathomechanics is not fully understood. Impaired lubrication is suspected to be the main reason. The management of patients impacted by this phenomenon is not well defined and, as it is not considered to be cause for alarm, revision is not strongly recommended. Here, we describe a ceramic insert fracture discovered during revision surgery performed to correct severe squeaking. Preoperative investigation (plain X-rays, ultrasound and computed tomography) did not reveal ceramic fracture or definite component malposition. To date, there are no other published cases of incidental discovery of a bearing component fracture during revision of ceramic-on-ceramic hip replacement due to squeaking. We believe that squeaking is not a trivial phenomenon and recommend careful management of patients suffering with this symptom.

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BACKGROUND: Range of motion after hip arthroplasty may be limited by soft tissues around the hip, extra-articular contact and femoral stem-neck contact with the acetabular articular surface. Femoral head-neck diameter ratio is recognized as a major factor influencing hip range of motion. In hip resurfacing, range of motion is constrained by "cup component to femoral neck" contact. To avoid cup-to-bone contact or to increase the degree of flexion at which it occurs, anterior translation of the femoral component relative to the central femoral neck axis may improve anterior head-neck offset and hip flexion. We questioned whether low or high anterior femoral head to neck offset, cup inclination, stem anteversion, and component size influenced postoperative range of motion and hip flexion in patients who had undergone hip resurfacing. METHODS: We prospectively followed 66 patients (68 hips) who underwent hip resurfacing at a mean age at operation of 46.4 years (range, 19-60 years). Mean follow-up was 37.5 months (range, 33-41 months). No patient was lost to follow-up. All patients were evaluated clinically and range of motion was precised. Radiological measurement evaluated the anterior femoral head-neck offset. FINDINGS: Mean anterior neck-head offset was 7.5mm (range, 5-12 mm). We found significant linear regression correlation between anterior offset and flexion (R=0.66) and between anterior offset and global range of motion (R=0.51). One millimeter of anterior offset increased hip range of motion by 5° in flexion. No significant correlations were found between global range of motion or flexion arc of motion and component size, stem anteversion, cup inclination, gender ratio, preoperative arc of flexion or global range of motion. INTERPRETATION: Restoring or improving deficient anterior femoral head-neck offset appears important for restoring postoperative range of motion and specifically hip flexion.

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INTRODUCTION: Impingement is a factor of failure in total hip replacement (THR), causing instability and early wear. Its true frequency is not known; cup-retrieval series reported rates varying from 27 to 84%. HYPOTHESIS: The hypothesis was that a large continuous series of THR cup removals would help determine the frequency of component impingement. OBJECTIVES: The hypothesis was tested on a continuous retrospective series of cups removed in a single center, with a secondary objective of identifying risk factors. MATERIAL AND METHODS: [corrected] Macroscopic examination looked for component impingement signs in 416 cups retrieved by a single operator between 1989 and 2004. Risk factors were investigated by uni- and multivariate analyses in the 311 cases for which there were complete demographic data. In these 311 cases, removal was for aseptic loosening (131 cases), infection (43 cases), instability (56 cases), osteolysis (28 cases) or unexplained pain (48 cases); impingement was explicitly implicated in only five cases (1.6%), always with hard-on-hard bearing components. RESULTS: Impingement was found in 214 of the 416 cups (51.4%) and was severe (notch>1mm) in 130 (31.3%). In the subpopulation of 311 cups, impingement was found in 184 cases (59.2%) and was severe in 109 (35%). Neither duration of implant use nor cup diameter or frontal orientation emerged as risk factors. On univariate analysis, impingement was more frequently associated with revision for instability, young patient age at THR, global hip range of motion >200° or use of an extended femoral head flange (or of an elevated antidislocation rim liner), and was more severe in case of head/neck ratio<2. On multivariate analysis, only use of an extended head flange (RR 3.2) and revision for instability (RR 4.2) remained as independent risk factors for impingement. DISCUSSION: Component impingement is frequently observed in cups after removal, but is rarely found as a direct indication for revision, except in case of hard-on-hard friction couples (polyethylene being the most impingement-tolerant material). Systematic use of extended head flanges and elevated antidislocation rims is not to be recommended, especially in case of excessive ROM. A good head/neck ratio should be sought, notably by increasing the head diameter in less impingement-tolerant hard-on-hard friction couples. Although not identified as a risk factor in the present study, implant orientation should be checked; computer-assisted surgery can be useful in this regard, for adaptation to the patient's individual range-of-motion cone.

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INTRODUCTION: Osteoarthritis lesions extent and dysplasia severity (negative vertical center edge [CE] angle) are recognized as unfavorable criteria for the survival of shelf arthroplasties performed for correcting hip dysplasia. Labral tears have recently been described on dysplastic hips, indicating beginning osteoarthritis and worsening the risk of instability. HYPOTHESIS: The labral tears identified in the course of shelf arthroplasty procedures for correction of hip dysplasia carry a predictive value for the survival of this operation. OBJECTIVES: Evaluate this hypothesis at the intermediate term in a long-term prospective observational study. PATIENT AND METHODS: Eighteen adult patients (18 dysplastic hips) having undergone shelf arthroplasty were included consecutively in a continuous prospective study. At the time the shelf arthroplasty was performed, a hip arthroscopic exam was carried out to search for and resect a labral tear if necessary. Fifteen patients were reviewed with a minimum follow-up of 16 years. Two patients died and one patient was lost to follow-up. RESULTS: During arthroscopic exploration, 10 hips presented labral tears (55.6%). At a mean follow-up of 16.3 years (range, 16-18 years), eight hips underwent hip arthroplasty. Of these hips, only one did not present a labral tear. The seven other hips had a tear of the labrum (p<0.001). The overall survival rate was 41.3%; it was 83.3% for hips with no labral tear and 15.2% for hips with a lesion of the labrum (p=0.048). DISCUSSION AND CONCLUSION: Labral tears had a negative impact on the outcome of shelf arthroplasty for hip dysplasia. This lesion therefore warrants being sought using appropriate exploration techniques (MRI or CT-arthrography) before shelf arthroplasty surgery. The existence of a preoperative labral tear does not seem to cast doubt on shelf arthroplasty itself. However, it should be identified so as to set objectives and expectations: long-term survival is significantly lower in the presence of a labral tear. It seems preferable to repair this type of lesion with arthroscopic guidance during shelf arthroplasty to prevent a potential source of residual pain, keeping in mind that secondary resection will be more difficult after covering the lesion. LEVEL OF EVIDENCE: Level 3 prospective observational prognostic study.

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INTRODUCTION: Securing femoral offset should in theory improve hip stability and abductor muscles moment arms. As problems arise mainly in case of originally increased offset (>40 mm), a range of extra-offset stems is available; the exact impact in terms of fixation, however, is not known. HYPOTHESIS: Extra-offset stems should more reliably reestablish original femoral offsets exceeding 40 mm than standard femoral components, limiting instability risk without possible adverse effect on fixation. OBJECTIVE: To compare the ability of five commonly available femoral stem designs to restitute offset exceeding 40 mm, and to assess function and cement fixation at a minimum 6 years' follow-up in a stem conceived to reproduce such offset. PATIENTS AND METHODS: A continuous series of 74 total hip replacements (THR) in hips with increased (>40 mm) femoral offset was studied. All underwent preoperative X-ray templating on Imagika™ software to assess offset reproduction by five models of stem: four standard, and one Lubinus SP2™ extra-offset stem. A retrospective clinical and X-ray study was conducted with a minimum 6 years' follow-up on the Lubinus SP2™ 117° stems used to try to reproduce offset in the 74 THRs. RESULTS: Apart from the increased (>40 mm) offset, the cervicodiaphyseal angle was consistently <135°, <130° in 60 femurs (81%) and <125° in 45 (60%). Planning showed the four standard stems to induce (>5mm femoral offset reduction in 50-83% of cases, versus only 25% with the Lubinus SP2™ 117°). All 74 hips received Lubinus SP2™ 117° stems: at a mean 78 months FU (range, 70-94 mo), their mean Postel-Merle d'Aubigné score was 17±1.8 (range, 13-18). Five of the 74 THRs underwent surgical revision: three cases of loosening, in which the stem was replaced, and two of instability, without change of stem. Loosening was not related to offset reproduction quality; two of the three cases were due to initial cementing defect, and the third occurred in a femur with previous history of two osteotomies. There were four cases of dislocation (5.4%: two primary, which were not operated on, and two recurrent, managed by acetabular revision), despite good reproduction of the preoperative offset in three of the four cases. Mean 7-year implant survivorship was 95.1% (±4.8). DISCUSSION AND CONCLUSION: The anatomic form of the Lubinus™ SP2 117° should in theory provide a uniform cement mantle. Survivorship, however, is less good than for regular offset versions (126° or 135°). On the other hand, it does reproduce anatomy in case of >40mm offset, providing extra offset of more than 51mm. The slightly shorter survivorship requires more long-term surveillance. LEVEL OF EVIDENCE: Level IV, retrospective study.

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PURPOSE OF THE STUDY: Infection is a rare complication of shoulder arthroplasty. Various therapeutic solutions have been proposed: antibiotics alone, one-stage or two-stage reimplantation, surgical or arthroscopic cleaning without prosthesis removal, scapulohumeral arthrodesis or simple arthroscopic resection. We evaluated the mid-term clinical outcome after resection arthroplasty for the treatment of infected shoulder arthroplasty. MATERIAL AND METHODS: The series included ten infected arthroplasties in ten patients. Mean duration of implantation was two years seven months (range nine months to five years). Bacteriological diagnosis was established from intraoperative articular samples or systematic samples taken during surgical revision procedures: meti-S Staphylococcus aureus strains (n=4), coagulase-negative Staphylococcus (n=5 including three S. epidermidis) Streptococcus mitis (n=1) and Citrobacter koseri (n=1). The mean Constant score before revision was 58 (range 23-77). Subjective patient satisfaction before surgical revision was rated good in six cases, fair in one and poor in three. Surgery associated removal of the implant, complete resection of the cement, resection of the fistular tracts, wide debridement of infected tissues and total synovectomy. RESULTS: Patients were seen at an average follow-up of three years eight months. The objective functional outcome measured with the Constant score was only fair, 28 points (range 20.6-36), and corresponded to a loss of 29 points compared with the preoperative score. This was explained mainly by lower scores for joint motion, function and muscle force but with persistently satisfactory scores for pain. All patients remained pain-free (daytime and nighttime). Patient satisfaction was rated good for two, fair for five and mediocre for three. Clinical and biological proof of eradicated infection was obtained in all patients. DISCUSSION: Infection remains a serious devastating problem for shoulder arthroplasty with an important functional impact. Resection only has a modest clinical effect. Precise identification of the causal germ with institution of adapted antibiotic therapy is required for eradication of the infection. Early diagnosis is probably the most important parameter affecting clinical outcome and surgical options. Functional results after resection arthroplasty are modest. This procedure should be reserved for patients with reduced functional demands. Improved management of the infectious load and reduction of diagnostic delay should help improve functional outcome and favor use of stow-stage procedures for reinsertion.

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We report here the purification and the crystallization of the modular protein Grb2. The protein was expressed as a fusion with glutathione-S-transferase and purified by affinity chromatography on glutathione agarose. It was apparent from reverse phase chromatography that the purified protein was conformationally unstable. Instability was overcome by the addition of 100 mM arginine to the buffers. Because Grb2 appeared to be extremely sensitive to oxidation, crystallization experiments were performed with a dialysis button technique involving daily addition of fresh DTT to the reservoirs. The presence of 8 to 14% glycerol was necessary to obtain monocrystals. These results are discussed in relation with the modular nature of Grb2.

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