RESUMEN

Hemidecortication, which consists of removing one cerebral hemisphere, leaving intact the thalamus and hypothalamus, affects the hypothalamus-hypophyseal axis producing hypothyroidism. Hemidecorticate rats showed a significant decrease in the weekly eruption rate of the upper incisors and partial recovery after the administration of thyrotrophin-releasing hormone (TRH). The uptake of [3H]-glycine, 1 and 4 h after a single injection, shown by radioautography, was 25 to 50 per cent higher in the periodontal ligament of the experimental animals. Most of the labelled material was non-collagenous proteins because only 20 to 30 per cent was removed by collagenase.

Asunto(s)

Glicina/metabolismo , Ligamento Periodontal/metabolismo , Hormonas Tiroideas/fisiología , Erupción Dental , Animales , Corteza Cerebral/fisiología , Incisivo , Masculino , Ratas , Ratas Endogámicas , Hormona Liberadora de Tirotropina/farmacología , Erupción Dental/efectos de los fármacos