RESUMEN
OBJECTIVE: To determine whether the occurrence of seizures is correlated with the presence of serum antiphospholipid antibodies (aPL) in systemic lupus erythematosus (SLE) patients. METHODS: The study included 221 unselected patients with SLE. Of these, 21 patients with epileptic seizures not attributed to any cause other than SLE were identified. Epilepsy was diagnosed by clinical history and electroencephalography. Blood samples were tested for the presence of antibodies to cardiolipin (aCL, IgG and IgM isotypes) and lupus anticoagulant (LAC). RESULTS: LAC was detected in 43.8% of the patients with epilepsy and in 20.8% of controls (P = 0.057). A statistically significant association was found between moderate-to-high titers of IgG aCL and the presence of seizures (P = 0.02). Brain computed tomography and/or magnetic resonance imaging scanning was performed in 14 patients. All patients with abnormal features found on these tests had positive aPL (P = 0.03). Nine patients (42.9%) had at least 1 of the classic features associated with the aPL syndrome. CONCLUSION: We confirmed that epilepsy as a primary neuropsychiatric event is significantly associated with moderate-to-high titers of IgG aCL in SLE patients. Our results suggest that aPL could have a role in the etiopathogenesis of epilepsy in SLE.
Asunto(s)
Anticuerpos Anticardiolipina/sangre , Epilepsia/inmunología , Inhibidor de Coagulación del Lupus/sangre , Lupus Eritematoso Sistémico/inmunología , Adulto , Epilepsia/sangre , Epilepsia/complicaciones , Femenino , Humanos , Lupus Eritematoso Sistémico/sangre , Lupus Eritematoso Sistémico/complicaciones , Masculino , Persona de Mediana EdadAsunto(s)
Anticuerpos Antifosfolípidos/análisis , Lupus Eritematoso Sistémico/inmunología , Lupus Eritematoso Sistémico/psicología , Trastornos Mentales/etiología , Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Humanos , Masculino , Trastornos Mentales/inmunología , Persona de Mediana EdadRESUMEN
Frequency and severity of football related injuries have been registered on 90 swiss championship players. A multifactorial evaluation was then done, taking into account age, duration of football practice and number of training hours. Analysis was made of type and place of the injury, its origin as well as the length of the recovery period. The highest injury rate occurs in August (start of the championship). In the national leagues, a team will be hit by 20 injuries on average every half season, 20% of which require a break in the sports activity. The incidence of injuries depends on the performance level. Its values varies between 2.1 and 10.7 per 1000 hours of football play, the highest frequency being seen in the lower leagues. 40% of the mishaps happen during training sessions and 70% of all injuries require a recovery period of more than one week. The best protection rests on a mix of thorough warming up, regular stretching sessions for the legs and a well applied taping, even for preventive purposes.
Asunto(s)
Fútbol/lesiones , Heridas y Lesiones/epidemiología , Adolescente , Adulto , Humanos , Incidencia , Masculino , Estaciones del Año , Suiza/epidemiología , Factores de Tiempo , Heridas y Lesiones/rehabilitaciónRESUMEN
Neuropathic joint disease (described by J.M. Charcot in 1868) is now most commonly seen in patients with diabetic mellitus. We present a patient suffering from a characteristic diabetic neuro-arthropathy of the foot. We report the clinical features, roentgenographic signs, new diagnostic possibilities, and treatment.
Asunto(s)
Artropatía Neurógena/diagnóstico , Calcáneo/lesiones , Diabetes Mellitus Tipo 1/diagnóstico , Neuropatías Diabéticas/diagnóstico , Fracturas por Estrés/diagnóstico , Calcáneo/patología , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana EdadRESUMEN
Eosinophilic fasciitis (EF), described for the first time in 1974 by Shulman, is characterized by induration and inflammation of the fascia of the extremities. The disorder is associated with peripheral blood eosinophilia, hypergammaglobulinemia and an elevated erythrocyte sedimentation rate. In most patients the clinical and laboratory features improve following administration of systemic corticosteroids. Since 1978 several patients with EF and various hematologic disorders have been described. In this report we present a female patient aged 62 exhibiting, besides symptoms indicative of EF, features of Hashimoto thyroiditis and aplastic anemia. In the review of the literature we compare 209 patients with EF including 15 cases with additional hematologic disorder.