Asunto(s)
Ecocardiografía Doppler/métodos , Neoplasias Cardíacas/complicaciones , Prolapso de la Válvula Mitral/diagnóstico por imagen , Mixoma/complicaciones , Diástole/fisiología , Femenino , Atrios Cardíacos , Neoplasias Cardíacas/diagnóstico por imagen , Humanos , Persona de Mediana Edad , Prolapso de la Válvula Mitral/etiología , Prolapso de la Válvula Mitral/fisiopatología , Mixoma/diagnóstico por imagenRESUMEN
Our recent segregation analysis, carried out on 27 large pedigrees from a Caribbean island (Desirade), has shown the presence of recessive major gene(s) controlling susceptibility to leprosy per se and nonlepromatous leprosy, respectively. Linkage analysis was performed between each of these two detected genes and each of five markers typed in the Desirade population: HLA, ABO, Rhesus, Gm and Km. No positive significant lod score was observed. However, for leprosy per se close linkage was excluded with Rhesus and Gm (and also with ABO and HLA, considering a lower value for the frequency of the gene controlling susceptibility to leprosy per se). The highest lod score, although not significant, was obtained between the gene for nonlepromatous leprosy and ABO. Our overall results, joined with previous studies and experimental data, suggest that the gene controlling susceptibility to leprosy per se and that controlling susceptibility to nonlepromatous leprosy might be different, acting at successive stages of the immune response to infection with Mycobacterium leprae.
Asunto(s)
Ligamiento Genético , Marcadores Genéticos , Lepra Lepromatosa/genética , Lepra/genética , Sistema del Grupo Sanguíneo ABO/genética , Susceptibilidad a Enfermedades , Antígenos HLA/genética , Humanos , Alotipos de Inmunoglobulinas/genética , Alotipos de Inmunoglobulina Gm/genética , Sistema del Grupo Sanguíneo Rh-Hr/genética , Indias OccidentalesRESUMEN
A random sample of 221 individuals taken from 2000 inhabitants of a small Caribbean island of French origin were typed for Gm and Km allotypes. Gm haplotype frequencies were found to be significantly different from France. Km(1) frequency was found to be lower than in the French population. These differences suggest a small degree of admixture with the Black population, and genetic drift.
Asunto(s)
Frecuencia de los Genes , Alotipos de Inmunoglobulinas/genética , Alotipos de Inmunoglobulina Gm/genética , Población Negra/genética , Francia/etnología , Humanos , Fenotipo , Distribución Aleatoria , Indias Occidentales , Población Blanca/genéticaRESUMEN
A relationship between markers related to the immune response (HLA system, Gm and Km immunoglobulin allotypes) and susceptibility to cutaneous leishmaniasis was investigated in a population of Hmong refugees who had recently settled in French Guiana. Two approaches were used: 1) case/control comparisons of the marker phenotype distribution to detect possible associations; 2) multiple-case family studies to search for marker-linked genes. When the distribution of HLA-A, B, C, antigens and Gm, Km allotypes was compared between patients and controls, only a significant decrease of HLA-Cw7 antigen among leishmaniasis patients was detected (p = 0.01). No interaction between any two of these markers and the disease was found. On the other hand, neither an HLA, Gm or Km susceptibility gene could be demonstrated in the informative sets of affected siblings. These results are discussed with respect to those reported in other infectious diseases.
Asunto(s)
Antígenos HLA/genética , Alotipos de Inmunoglobulinas/genética , Alotipos de Inmunoglobulina Gm/genética , Leishmaniasis/genética , Susceptibilidad a Enfermedades , Guyana Francesa , Frecuencia de los Genes , Marcadores Genéticos , Haplotipos , Humanos , Laos/etnología , Leishmaniasis/etnología , FenotipoRESUMEN
In the preceding pages the autor has endeavoured to give a short but as complete a study as possible on the problems of leprosy in Indonésia and of the evolution and results obtained from programme carried out to fight the disease during the period l956 to the end of l962. Prior to this project, no organised anti-leprosy plan existed. No method of detection, no active treatment, only isolation in a leprosarium, or at home, of a very small part of the 22,000 lepers known in l954. The sole treatment used was chaulmoogra oil. The objett of this project was to evalute the importance of the problem by studying the prevalence of the disease, to find the methods to combat leprosy suitable in the country concerned, to test them and, on the basis of experience acquired by means of pilot projects, to set up a plan on a national level...