Asunto(s)
Hemoglobinas Anormales/aislamiento & purificación , Talasemia/sangre , Adolescente , Adulto , Niño , Femenino , Humanos , Lactante , Masculino , Talasemia/genéticaRESUMEN
Efficacy of chelation therapy with intravenous calcium disodium edetate, oral Ca EDTA, and oral penicillamine was tested in 63 subjects with chronic minimal industrial exposure to lead. All three agents increased the urinary lead excretion. The effect was greatest with intravenous Ca EDTA, next with oral penicillamine and least with oral Ca EDTA. Symptoms, particularly colicky abdominal pain, improved during the period of chelation therapy. Anaemic subjects showed improvements in haematological parameters. It is recommended that subjects with chronic minimal industrial exposure to lead receive chelation therapy. The relative merits of the three agents are discussed.
Asunto(s)
Ácido Edético/uso terapéutico , Intoxicación por Plomo/tratamiento farmacológico , Adulto , Enfermedad Crónica , Ensayos Clínicos como Asunto , Ácido Edético/administración & dosificación , Exposición a Riesgos Ambientales , Humanos , Plomo/orina , Intoxicación por Plomo/orina , Masculino , Penicilamina/administración & dosificación , Penicilamina/uso terapéuticoRESUMEN
Among 1052 women from Northern Thailand whose bloods were examined for haemoglobin variants by starch gel electrophoresis, 84 (8.0 per cent) had variant with the doubly-slow mobility associated with Haemoglobin E. Seventy-nine of those slow variants were examined by chemical structure studies and all were confirmed to have the change, beta26 Glu leads to Lys, associated with Haemoglobin E. These results indicate that other variants with mobilities like that of Haemoglobin E are uncommon in Thairs.
Asunto(s)
Hemoglobinas Anormales/análisis , Hemoglobinas Anormales/aislamiento & purificación , Adulto , Recolección de Muestras de Sangre , Electroforesis en Gel de Almidón , Femenino , Variación Genética , Heterocigoto , Homocigoto , Humanos , Péptidos/análisis , TailandiaRESUMEN
A hemoglobin variant with the slightly fast mobility associated with K hemoglobins was found, together with hemoglobin S, in an apparently healthy 3-year-old Negro girl from Washington, D.C. Her father had the same variant, along with hemoglobin A, and her mother had hemoglobins A plus S. Respective proportions of hemoglobins K and S in the propositus were 66-34. The K variant now has been found to have the structural change Gln yields Glu at position beta-131 (beta-H9); therefore it apparently is identical to hemoglobin Camden reported in trait form in a Negro subject by YATES, BELLINGHAM and HUEHNS (Nature 243: 467-468, 1973).