RESUMEN
Malakoplakia is an unusual chronic inflammatory disease related to prior urinary tract infection. It is characterized by the presence of macrophages with foamy cytoplasm exhibiting larger PAS positive inclusions that stain for calcium and iron. Malakoplakia affects renal allograft and is associated with severe morbidity. Herein, the authors report a new case of renal graft malakoplakia in a 23-year-old female patient. The patient received a living-related donor renal transplantation with a high immunological risk. Plasmapheresis and intravenous immunoglobulin (i.v. Ig) treatment, pre- and post-transplant, and induction with rabbit anti-thymocyte globulins were used due to presence of donor specific antibodies and positive B cross match by flow cytometry. The patient had an early urinary tract infection with a good outcome. On Day 36 post-transplant (PO), the patient returned to the clinic with fever, graft pain and acute renal dysfunction leading to hemodialysis. Escherichia coli (E. coli) was present in the blood and urine culture. At the time, the renal biopsy revealed numerous sheets of macrophages with foamy, eosinophilic cytoplasm showing several PAS positive granules and large inclusions that stained strongly with hematoxylin, calcium (von Kossa method) and iron (Prussian blue). The patient was diagnosed with malakoplakia related to a kidney transplant. Despite prolonged treatment with antibiotics, determined by a susceptibility test, the patient did not recover renal function and remained on dialysis.
Asunto(s)
Infecciones por Escherichia coli/etiología , Trasplante de Riñón/efectos adversos , Malacoplasia/etiología , Infecciones Urinarias/etiología , Antibacterianos/uso terapéutico , Biopsia , Infecciones por Escherichia coli/diagnóstico , Infecciones por Escherichia coli/terapia , Femenino , Histocompatibilidad , Humanos , Inmunosupresores/efectos adversos , Donadores Vivos , Malacoplasia/diagnóstico , Malacoplasia/terapia , Diálisis Renal , Infecciones Urinarias/diagnóstico , Infecciones Urinarias/terapia , Adulto JovenRESUMEN
AIMS: to analyze the frequency of transplants using expanded donor criteria (EDC) and the incidence of delayed graft function, acute rejection and the patient and graft survival compared to ideal donors (ID). PATIENTS: retrospective analysis of the 582 cadaver renal transplants performed from Jun 1988 to Mar 2003 in adult recipients. The expanded donor criteria were considered as history of hypertension or evidence of atherosclerosis, diabetes, age less than 5 or more than 55 years old, serum creatinine higher than 2.0 mg/dL, shock and retrieval in cardiac arrest. The statistical analysis used was Student t test, Chi-square test, and Kaplan-Meier method as indicated. RESULTS: 25.4% of our transplants used expanded criteria donor. Comparing, respectively, the EDC and ID we found: the incidence of delayed graft function of 63.9% vs 50.4% (P: 0.007); incidence of acute rejection of 66.1% vs 72.3% (P: 0.203). The patient survival at 1 and 5 years was 87% vs 92% and 81% vs 79%, respectively (P: 0.6809). The graft survival at 1 and 5 year was 74% vs 82% and 57% vs 59% (P: 0.2072), respectively for EDC and ID. CONCLUSIONS: One fourth of our cadaver transplants fulfilled the extended donor criteria. The incidence of delayed graft function was higher in these transplants, but the prevalence of rejection episodes was similar to ideal donors. The patient and graft survival were not statistically different at 1 and 5 year.
Asunto(s)
Cadáver , Trasplante de Riñón , Donantes de Tejidos , Brasil/epidemiología , Rechazo de Injerto/epidemiología , Supervivencia de Injerto , Humanos , Incidencia , Selección de Paciente , Estudios Retrospectivos , Obtención de Tejidos y Órganos/métodosRESUMEN
Post-transplant lymphoproliferative disease (PTLD) is an uncommon but life-threatening complication of solid-organ and blood stem-cell transplants. It responds poorly to therapy, including reduction of immunosuppression, interferon, antivirals or chemotherapy. Small series of PTLD successfully treated with rituximab have been reported, and experimental studies suggest that rapamycin inhibits growth of human Epstein-Barr virus-transformed B lymphocytes. We report two cases of PTLD after renal transplantation that were successfully treated with rituximab in association with rapamycin. This report suggests that rituximab associated with rapamycin could be an effective and safe treatment for PTLD.
Asunto(s)
Anticuerpos Monoclonales/uso terapéutico , Inmunosupresores/uso terapéutico , Trasplante de Riñón/efectos adversos , Trastornos Linfoproliferativos/tratamiento farmacológico , Sirolimus/uso terapéutico , Adolescente , Anticuerpos Monoclonales de Origen Murino , Quimioterapia Combinada , Humanos , Trastornos Linfoproliferativos/etiología , Masculino , Rituximab , Factores de Tiempo , Resultado del TratamientoRESUMEN
From 1977 to July 2002, 1,376 renal transplants were performed at Santa Casa of Porto Alegre. The number of transplants and the patient and graft survival rates have been rising each year since 1987. The overall one-year graft survival rates were 90% for living donor recipients and 80% for cadaver donor recipients, respectively; however, the patient and graft survival rates increased significantly between the early (1977-1995) and more recent (1996-2002) periods. Pediatric patients (less than 18 years old) accounted for 15.8% of the transplants that were performed, most of them from living related donors. The patient and graft survival rates did not differ statistically when we compared recipients of transplants from "ideal" and marginal cadaver donors, even when we considered only those risk factors that affected graft function in assigning a marginal donor. During the 25-year observation period, 537 grafts have been lost (39%), including those patients who died with functioning graft. We are currently following 834 patients with a functioning graft, with an average follow-up of 67+54 months.
Asunto(s)
Supervivencia de Injerto/fisiología , Trasplante de Riñón/estadística & datos numéricos , Análisis Actuarial , Adolescente , Adulto , Brasil , Cadáver , Niño , Femenino , Humanos , Trasplante de Riñón/mortalidad , Trasplante de Riñón/fisiología , Donadores Vivos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Tasa de Supervivencia , Factores de Tiempo , Donantes de TejidosRESUMEN
Os autores apresentam uma revisäo dos mecanismos de açäo, paraefeitos e interaçöes mais comumente utilizadas nos tranplantes de órgäos, com especial atençäo para o uso concomitante destes imunossupressores com antibióticos, anticonvulsivantes e drogas de açäo cardiovascular
Asunto(s)
Humanos , Inmunosupresores/efectos adversos , Azatioprina , Ciclosporina , Corticoesteroides , Trasplante de ÓrganosRESUMEN
É apresentada a experiência do Serviço de Nefrologia da Santa Casa de Porto Alegre com o Transplante Simultâneo de Rim e Pâncreas (TxSRP) em diabéticos insulino-dependentes urêmicos. Entre agosto de 1987 e fevereiro de 1996 foram realizados nove TxSRP. A sobrevida do paciente do rim e do pâncreas foi de 88,9 por cento, 77,8 por cento e 76,2 por cento no primeiro ano e de 63,4 por cento, 51,8 por cento e 50,7 por cento no terceiro ano. Ocorreram quatro óbitos. Foram perdidos um enxerto renal e um pancreático. Ao final da observaçäo, cinco pacientes estavam vivos com enxerto renal funcionante e quatro com funçäo pancreática normal. O TxSRP pode, em determinadas situaçöes, ser uma alternativa para o tratamento de diabéticos insulino-dependentes urêmicos necessitando de transplante renal.
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Trasplante de Riñón , Diabetes Mellitus Tipo 1/cirugía , Trasplante de Páncreas , Trasplante de Riñón/efectos adversos , Análisis de Supervivencia , Rechazo de Injerto , Trasplante de Páncreas/efectos adversosRESUMEN
Realizada uma avaliaçao dos seis anos de atividade da Coordenadoria de transplantes do RS (1988 a 1993). Sao apresentados suas normas de funcionamento e seus objetivos, os quais foram parcialmente obtidos neste período. Há uma equipe de procura de órgaos e uma equipe de remoçao de rins funcionando ininterruptamente. Há um registro dos doadores e dos transplantes renais realizados no Estado.A taxa de potenciais doadores é conhecida (40,8pmp/ano), o número de transplantes renais com doador cadáver está aumentando, tendo sido realizados, em 1993, 15,5 transplantes pmp, representando 62 por cento dos transplantes naquele ano e foram removidos múltiplos órgaos em 22 por cento dos doadores. Foram estabelecidos novos objetivos para os próximos quatro anos.
Asunto(s)
Trasplante de Riñón , Organización y Administración , Donantes de TejidosRESUMEN
O transplante renal por oferecer melhor qualidade de vida e maior sobrevida com menor custo social e o tratamento de escolha para a maioria dos pacientes uremicos cronicos. Os autores abordam os criterios usados na selecao do receptor de transplante renal, assim como aspectos medicos, eticos e legais na selecao do potencial doador vivo e cadaver
Asunto(s)
Humanos , Masculino , Femenino , Donantes de Tejidos , Trasplante de Riñón , Insuficiencia Renal Crónica/terapia , Diálisis , Ética MédicaRESUMEN
Säo relatados dois casos de pacientes portadores de insuficiência cardíaca congestiva, que desenvolveram hiponatremia acentuada com o uso de captopril e sem a ocorrência de balanço hídrico positivo. Com a suspensäo da droga e manutençäo das medidas que vinham sendo empregadas, houve elevaçäo de sódio sérico. A troca do captopril por enalapril também provocou queda acentuada do sódio sérico, motivando a sua suspensäo